The New York Philharmonic Strike of 1973

The New York Philharmonic Strike of 1973 is a story waiting to be told. The sole volume to mention it, John Canarina\u27s The New York Philharmonic, devotes less than two pages to it. Until now, the full story has lain buried in archival documents, newspaper articles, and the memories of those who experienced it firsthand. This document represents the first comprehensive examination of this event. The research upon which it is based consists of: interviews with the New York Philharmonic members; research in the New York Philharmonic Archives; newspaper articles and reviews. The results are presented here in three interrelated narratives: a) the historical background to the tenor of labor relations between orchestral musicians and their respective managements in the United States going back more than a century, with a detailed focus upon past labor relations of the New York Philharmonic; b) a comprehensive narrative of the 1973 strike; and c) a study of the consequences of the strike for the Philharmonic with an overview of current and potentially future problems in labor relations for both the Philharmonic and rest of American symphony orchestras

Solving time-dependent PDEs with the ultraspherical spectral method

We apply the ultraspherical spectral method to solving time-dependent PDEs by proposing two approaches to discretization based on the method of lines and show that these approaches produce approximately same results. We analyze the stability, the error, and the computational cost of the proposed method. In addition, we show how adaptivity can be incorporated to offer adequate spatial resolution efficiently. Both linear and nonlinear problems are considered. We also explore time integration using exponential integrators with the ultraspherical spatial discretization. Comparisons with the Chebyshev pseudospectral method are given along the discussion and they show that the ultraspherical spectral method is a competitive candidate for the spatial discretization of time-dependent PDEs

FFTPL: An Analytic Placement Algorithm Using Fast Fourier Transform for Density Equalization

We propose a flat nonlinear placement algorithm FFTPL using fast Fourier transform for density equalization. The placement instance is modeled as an electrostatic system with the analogy of density cost to the potential energy. A well-defined Poisson's equation is proposed for gradient and cost computation. Our placer outperforms state-of-the-art placers with better solution quality and efficiency

Ginseng essence, a medicinal and edible herbal formulation, ameliorates carbon tetrachloride-induced oxidative stress and liver injury in rats

AbstractBackgroundGinseng essence (GE) is a formulation comprising four medicinal and edible herbs including ginseng (Panax ginseng), American ginseng (Panax quinquefolius), lotus seed (Nelumbo nucifera), and lily bulb (Lilium longiflorum). This study was aimed at investigating the hepatoprotective effect of GE against carbon tetrachloride (CCl4)-induced liver injury in rats.MethodsWe treated Wistar rats daily with low, medium, and high [0.625 g/kg body weight (bw), 1.25 g/kg bw, and 3.125 g/kg bw, respectively] doses of GE for 9 wk. After the 1st wk of treatment, rats were administered 20% CCl4 (1.5 mL/kg bw) two times a week to induce liver damage until the treatment ended.ResultsSerum biochemical analysis indicated that GE ameliorated the elevation of aspartate aminotransferase and alanine aminotransferase and albumin decline in CCl4-treated rats. Moreover, CCl4-induced accumulation of hepatic total cholesterol and triglyceride was inhibited. The hepatoprotective effects of GE involved enhancing the hepatic antioxidant defense system including glutathione, glutathione peroxidase, glutathione reductase, glutathione S-transferase, superoxide dismutase, and catalase. In addition, histological analysis using hematoxylin and eosin and Masson's trichrome staining showed that GE inhibited CCl4-induced hepatic inflammation and fibrosis. Furthermore, immunohistochemical staining of alpha-smooth muscle actin indicated that CCl4-triggered activation of hepatic stellate cells was reduced.ConclusionThese findings demonstrate that GE improves CCl4-induced liver inflammation and fibrosis by attenuating oxidative stress. Therefore, GE could be a promising hepatoprotective herbal formulation for future development of phytotherapy

Exploration of Building Information Modeling and Integrated Project Cloud Service in early architectural design stages

[EN] In the evolving Architecture, Engineering, and Construction (AEC) industry, the use of Building Information Modeling (BIM) and Integrated Project Cloud Service (IPCS) has become crucial. These tools are particularly essential during the early design stages, as they enable comprehensive management and integration of project information, thus promoting effective decision-making throughout project lifecycles. This combined approach enhances inter-organizational collaborations, improves design and construction practices, and creates a communal data platform for stakeholders. This research explores the effectiveness of the BIM-IPCS system in streamlining data exchange and information flow during early design, suggesting ways to minimize errors, speed up processes, and reduce construction costs through dependable networks. Conclusively, this study underscores the significant impact of the BIM-IPCS system on project management, ensuring well-coordinated and informed construction while advocating for its role in driving innovative and efficient project delivery in the AEC industry.Grateful acknowledgment is extended to the National Taiwan University of Science and Technology, the Public Works Information Institute of the Republic of China (CPWEIA), and Luxor Digital Co., Ltd. (LUXOR) for their substantial support and contributions to this research.Wagiri, F.; Shih, S.; Harsono, K.; Cheng, T.; Lu, M. (2023). Exploration of Building Information Modeling and Integrated Project Cloud Service in early architectural design stages. VITRUVIO - International Journal of Architectural Technology and Sustainability. 8(2):26-37. https://doi.org/10.4995/vitruvio-ijats.2023.2045326378

Exploration of Building Information Modeling and Integrated Project Cloud Service in early architectural design stages

In the evolving Architecture, Engineering, and Construction (AEC) industry, the use of Building Information Modeling (BIM) and Integrated Project Cloud Service (IPCS) has become crucial. These tools are particularly essential during the early design stages, as they enable comprehensive management and integration of project information, thus promoting effective decision-making throughout project lifecycles. This combined approach enhances inter-organizational collaborations, improves design and construction practices, and creates a communal data platform for stakeholders. This research explores the effectiveness of the BIM-IPCS system in streamlining data exchange and information flow during early design, suggesting ways to minimize errors, speed up processes, and reduce construction costs through dependable networks. Conclusively, this study underscores the significant impact of the BIM-IPCS system on project management, ensuring well-coordinated and informed construction while advocating for its role in driving innovative and efficient project delivery in the AEC industry

Correlation of Interleukin-17-Producing Effector Memory T Cells and CD4 +

Background and Objectives. Hyperparathyroidism and hyperphosphatemia contribute to the inflammatory effects in chronic hemodialysis (HD) patients. Interleukin-17-producing CD4+ effector memory T (Th17) cells and CD4+CD25+Foxp3 regulatory T (Treg) cells both play critical roles in immune activation and inflammation. We investigated the relationship between the Treg and Th17 cells and the phosphate level in chronic HD patients. Methods. 105 patients aged ≥35 years on chronic HD over 3 months were enrolled. The peripheral blood mononuclear cells were collected, cultured, and stimulated by phytohemagglutinin-L, phorbol myristate acetate, and ionomycin at different time points for T cell differentiation. Results. The T cell differentiation was as follows: Th17 cells (mean ± standard deviation (SD): 25.61% ± 10.2%) and Treg cells (8.45% ± 4.3%). The Th17 cell differentiation was positively correlated with the phosphate and albumin levels and negatively correlated with age. The Treg cell differentiation was negatively correlated with albumin level and age. In the nondiabetes group (n=53), the Th17 cell differentiation was predominantly correlated with the phosphate and iPTH (intact parathyroid hormone) levels as well as the dialysis vintage. Conclusion. Higher phosphate and iPTH levels and longer dialysis duration may increase Th17 cell differentiation, especially in the nondiabetic chronic HD patients

The incidence and risk of developing a second primary esophageal cancer in patients with oral and pharyngeal carcinoma: a population-based study in Taiwan over a 25 year period

<p>Abstract</p> <p>Background</p> <p>The incidence of oral and pharyngeal (including oral cavity, oropharynx and hypopharynx) carcinoma increases rapidly in Asia and South Pacific because of betel quid chewing. Thus far, large-scale epidemiological studies are not available yet to stratify these patients by their risks of developing a second primary cancer in the digestive tract including esophagus, stomach, colon, and rectum.</p> <p>Methods</p> <p>A population-based study was conducted using the database from the Taiwan National Cancer Registry for the period 1979-2003. We quantified standardized incidence ratios (SIRs) and cumulative incidence of second primary cancers among 33,787 patients with initial diagnoses of oral and pharyngeal carcinoma.</p> <p>Results</p> <p>Among these four digestive tract organs, the esophagus was the only site of second cancer with excess risk in patients with oral and pharyngeal carcinoma. The incidence and risk of developing a second primary esophageal cancer differed by the site of the primary index tumor, most frequently seen in hypopharyngeal cancer (71/4,218 = 1.68%, SIR = 22.76, 95% CI 17.77-28.70), followed by oropharyngeal cancer (30/3,403 = 0.88%, SIR = 14.29, 95% CI 9.64-20.39) and the least in oral cavity cancer (99/26,166 = 0.38%, SIR = 5.57, 95% CI 4.53-6.78). In addition, the risk was extraordinarily high for patients with a follow-up interval ≤ 1 year and those with first primary cancer diagnosed at age ≤50. These patients may justify more close surveillance.</p> <p>Conclusion</p> <p>The present study represents the first population-based study in Asia attempting to stratify the patients of oral and pharyngeal carcinoma by their risk of developing a second esophageal cancer. It helps identify patients at high risk and tailor the application of intense follow-up surveillance to the estimated risk in each individual case.</p