SIMULAÇÃO LOGÍSTICA EM UMA EMPRESA DO SETOR PÚBLICO

Este trabalho tem por objetivo  fazer uma simulação logística em uma empresa pública cuja  responsabilidade é a elaboração e emissão de documentos primordiais para o cidadão, buscando com isso uma melhoria para a empresa. O método utilizado foi uma simulação no software Arena que nos possibilita observar todos os processos realizados pela empresa e verificar em qual etapa essa melhoria será aplicada. O método é eficaz e eficiente pois ele fornece relatórios precisos do desenvolvimento atual da empresa. Após a coleta de dados e correto abastecimento  do sistema, os demonstrativos relataram uma utilização exacerbada do funcionário Caixa. Outro ponto muito importante remete à relação da visibilidade das filas formadas no setor  Banco, estas se excedem a um número de 51 usuários, este tipo de atendimento causa  nos usuários uma sensação de descredibilidade para com o serviço. Com base nos dados levantados, foi realizada uma simulação de melhoria, em que as medidas tomadas são a contratação de mais um funcionário para Caixa e a abertura de mais um setor  Banco, com a finalidade de manter a satisfação do cliente. Dessa forma, chegamos à conclusão que a utilização do software foi primordial para identificar a melhoria obtida e que tal procedimento é fundamental para a otimização do serviço na empresa pública citada

Rotational Evolution of Classical T Tauri Stars: Models and Observations

We developed a grid of stellar rotation models for low-mass and solar-type Classical T Tauri stars (CTTS) ($0.3M_{\odot}<M_{\ast}<1.2M_{\odot}$). These models incorporate the star-disk interaction and magnetospheric ejections to investigate the evolution of the stellar rotation rate as a function of the mass of the star $M_{\ast}$, the magnetic field ($B_{\ast}$), and stellar wind ($\dot{M}_{wind}$). We compiled and determined stellar parameters for 208 CTTS, such as projected rotational velocity $v\sin(i)$, mass accretion rate $\dot{M}_{acc}$, stellar mass $M_{\ast}$, ages, and estimated rotational periods using TESS data. We also estimated a representative value of the mass-loss rate for our sample using the $[\text{O}\text{ I}]$ spectral line. Our results confirm that $v\sin(i)$ measurements in CTTS agree with the rotation rates provided by our spin models in the accretion-powered stellar winds (APSW) picture. In addition, we used the Approximate Bayesian Computation (ABC) technique to explore the connection between the model parameters and the observational properties of CTTS. We find that the evolution of $v\sin(i)$ with age might be regulated by variations in (1) the intensity of $B_{\ast}$ and (2) the fraction of the accretion flow ejected in magnetic winds, removing angular momentum from these systems. The youngest stars in our sample ($\sim$1 Myr) show a median branching ratio $\dot{M}_{wind}/\dot{M}_{acc}\sim$ $0.16$ and median $B_{\ast}\sim$ 2000 G, in contrast to $\sim 0.01$ and 1000 G, respectively, for stars with ages $\gtrsim 3$ Myr.Comment: 28 pages, 18 figures, Accepted for publication in Ap

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Rotational Evolution of Classical T Tauri Stars: Models and Observations

We developed a grid of stellar rotation models for low-mass and solar-type classical T Tauri stars (CTTS; 0.3 M _⊙ < M _* < 1.2 M _⊙ ). These models incorporate the star–disk interaction and magnetospheric ejections to investigate the evolution of the stellar rotation rate as a function of the mass of the star M _* , the magnetic field ( B _* ), and stellar wind ( ${\dot{M}}_{\mathrm{wind}}$ ). We compiled and determined stellar parameters for 208 CTTS, such as projected rotational velocity $v\sin (i)$ , mass accretion rate ${\dot{M}}_{\mathrm{acc}}$ , stellar mass M _* , ages, and estimated rotational periods using Transiting Exoplanet Survey Satellite (TESS) data. We also estimated a representative value of the mass-loss rate for our sample using the [O i ] λ 6300 spectral line. Our results confirm that $v\sin (i)$ measurements in CTTS agree with the rotation rates provided by our spin models in the accretion-powered stellar winds picture. In addition, we used the approximate Bayesian computation technique to explore the connection between the model parameters and the observational properties of CTTS. We find that the evolution of $v\sin (i)$ with age might be regulated by variations in (1) the intensity of B _* and (2) the fraction of the accretion flow ejected in magnetic winds, removing angular momentum from these systems. The youngest stars in our sample (∼1 Myr) show a median branching ratio ${\dot{M}}_{\mathrm{wind}}/{\dot{M}}_{\mathrm{acc}}\sim 0.16$ and median B _* ∼ 2000 G, in contrast to ∼0.01 and 1000 G, respectively, for stars with ages ≳3 Myr

Hydroxyurea alters hematological, biochemical and inflammatory biomarkers in Brazilian children with SCA: Investigating associations with βS haplotype and α-thalassemia.

This study investigated the effects of hydroxyurea (HU) on hematological, biochemical and inflammatory parameters in children with sickle cell anemia (SCA) in association with βS haplotype and α-thalassemia. We included 22 children with SCA who were followed for an average of 14.5 months. Laboratory parameters were assessed by electronic methods, and molecular analysis was investigated by PCR-RFLP and allele-specific PCR. Results showed significant increases in hemoglobin, HbF, hematocrit, MCV, MCH, glucose, HDL-C and albumin levels, as well as significant decreases in MCHC and AST levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes, in children during HU therapy. HbF levels were positively correlated with hemoglobin, hematocrit, MCV and total protein, yet negatively correlated with MCHC, RDW, AAT and AST during HU therapy (p<0.05). Children who carried the Central African Republic haplotype, in response to HU therapy, presented significant increases in hemoglobin, hematocrit, triglycerides and uric acid levels, as well as significant decreases in MCHC, AST and direct bilirubin levels, WBC, neutrophils, eosinophils, lymphocytes and reticulocytes. Those with the Benin haplotype presented increases in HbF and albumin levels, and a reduction in platelet counts (p<0.05). Children with α-thalassemia presented decreased ALT during HU use, while those without this deletion presented increases in hemoglobin, hematocrit, MCV, MCH, HDL-C and albumin, as well as decreases in MCHC, neutrophils, lymphocytes, reticulocytes and AST (p<0.05). Hence, regardless of its use in association with βS haplotypes or α-thalassemia, HU seems to be linked to alterations in hemolytic, inflammatory, hepatic, lipid and glycemic profiles

Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers.

Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to penile fibrosis and impotence. It is highly frequent in sickle cell disease (SCD) associated with hemolytic episodes. Our aim was to investigate molecules that may participate in the regulation of vascular tone. Eighty eight individuals with SCD were included, of whom thirty-seven reported a history of priapism. Priapism was found to be associated with alterations in laboratory biomarkers, as well as lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to be less affected by priapism. Multivariate analysis suggested that low HbF and NOm were independently associated with priapism. The frequency of polymorphisms in genes NOS3 and EDN1 was not statistically significant between the studied groups, and the presence of the variant allele was not associated with alterations in NOm and ET-1 levels in patients with SCD. The presence of the variant allele in the polymorphisms investigated did not reveal any influence on the occurrence priapism. Future studies involving larger samples, as well as investigations including patients in priapism crisis, could contribute to an enhanced understanding of the development of priapism in SCD

Role of paraoxonase 1 activity and PON1 gene polymorphisms in sickle cell disease

Abstract Sickle cell disease (SCD) patients often exhibit a dyslipidemic sub-phenotype. Paraoxonase 1 (PON 1) is a serum glycoprotein associated with the high-density lipoproteins cholesterol (HDL-C), and variability in PON1 activity depends on the PON1 genotypes. We investigated the influence of PON1c.192Q > R and PON1c.55L > M polymorphisms on PON1 activity and laboratory parameters and the association between PON1 activity and clinical manifestations in SCD patients. We recruited 350 individuals, including 154 SCD patients and 196 healthy volunteers, which comprised the control group. Laboratory parameters and molecular analyses were investigated from the participants' blood samples. We have found increased PON1 activity in SCD individuals compared to the control group. In addition, carriers of the variant genotype of each polymorphism presented lower PON1 activity. SCD individuals carrying the variant genotype of PON1c.55L > M polymorphism had lower platelet and reticulocyte counts, C-reactive protein, and aspartate aminotransferase levels; in addition to higher creatinine levels. SCD individuals carrying the variant genotype of PON1c.192Q > R polymorphism had lower triglyceride, VLDL-c, and indirect bilirubin levels. Furthermore, we observed an association between PON1 activity history of stroke and splenectomy. The present study confirmed the association between PON1c.192Q > R and PON1c.55L > M polymorphisms and PON1 activity, in addition to demonstrate their effects on markers of dislipidemia, hemolysis and inflammation, in SCD individuals. Moreover, data suggest PON1 activity as a potential biomarker related to stroke and splenectomy

O espetáculo do Ipiranga: reflexões preliminares sobre o imaginário da Independência

Este artigo constitui uma incursão inicial em relação ao tema do imaginário da Independência. Toma como questão central a construção de um monumento no Ipiranga, celebrativo da data de 7 de Setembro de 1822, e se propõe a discutir tal projeto, conforme foi formulado na década de 1870