Optimism and Social Support as Contributing Factors to Spirituality in Cancer Patients

Background/objective: The impact a cancer diagnosis and its treatment are affected by psychosocial factors and how these factors interrelate among themselves. The objective of this study was to analyze the relationship between optimism and social support in spiritual wellbeing in cancer patients initiating chemotherapy. Methods: A cross-sectional, multi-center (15 sites), prospective study was conducted with 912 cancer patients who had undergone curative surgery for a stage I-III cancer and were to receive adjuvant chemotherapy. They completed the Functional Assessment of Chronic Illness-Spiritual Well-being Scale (FACIT-Sp), Life Orientation Test-Revised (LOT-R), and the Multidimensional Scale of Perceived Social Support (MSPSS). Results: Significant differences on spirituality scales (meaning/peace and faith) were detected depending on age (≤ 65 vs > 65), sex, marital status, employment, and cancer treatment. Married or partnered participants had significantly higher meaning/peace scores compared to their non-partnered counterparts (p = 0.001). Women, > 65 years, unemployed, and patients treated with chemotherapy and radiotherapy had significantly higher faith scores versus men, ≤ 65 years, employed, and subjects only receiving adjuvant chemotherapy (all p < 0.030). Multivariate analyses indicated that meaning/peace and faith correlated positively with optimism and social support. Conclusion: During oncological treatment, the positive effects of optimism and social support exhibit a positive correlation with spiritual coping. A brief assessment evaluation of these factors can aid in identifying at risk for a worse adaptation to the disease

Breast cancer patient experiences through a journey map: A qualitative study.

Background: Breast cancer is one of the most prevalent diseases in women. Prevention and treatments have lowered mortality; nevertheless, the impact of the diagnosis and treatment continue to impact all aspects of patients' lives (physical, emotional, cognitive, social, and spiritual). Objective: This study seeks to explore the experiences of the different stages women with breast cancer go through by means of a patient journey. Methods: This is a qualitative study in which 21 women with breast cancer or survivors were interviewed. Participants were recruited at 9 large hospitals in Spain and intentional sampling methods were applied. Data were collected using a semi-structured interview that was elaborated with the help of medical oncologists, nurses, and psycho-oncologists. Data were processed by adopting a thematic analysis approach. Results: The diagnosis and treatment of breast cancer entails a radical change in patients' day-today that linger in the mid-term. Seven stages have been defined that correspond to the different medical processes: diagnosis/unmasking stage, surgery/cleaning out, chemotherapy/loss of identity, radiotherapy/transition to normality, follow-up care/the 'new' day-today, relapse/starting over, and metastatic/time-limited chronic breast cancer. The most relevant aspects of each are highlighted, as are the various cross-sectional aspects that manifest throughout the entire patient journey. Conclusions: Comprehending patients' experiences in depth facilitates the detection of situations of risk and helps to identify key moments when more precise information should be offered. Similarly, preparing the women for the process they must confront and for the sequelae of medical treatments would contribute to decreasing their uncertainty and concern, and to improving their quality-of-life

Ascertaining breast cancer patient experiences through a journey map: A qualitative study protocol

This study seeks to describe breast cancer patients' experience over the course of the various stages of illness by means of a journey model. This is a qualitative descriptive study. Individual, semi-structured interviews will be administered to women with breast cancer and breast cancer survivors. Patients will be recruited from nine large hospitals in Spain and intentional sampling will be used. Data will be collected by means of a semi-structured interview that was elaborated with the help of medical oncologists, nurses, and psycho-oncologists. Data will be processed adopting a thematic analysis approach. The outcomes of this study will afford new insights into breast cancer patients' experiences,providing guidance to improve the care given to these individuals. This protocol aims to describe the journey of patients with breast cancer through the healthcare system to establish baseline data that will serve as the basis for the development and implementation of a patient-centered, evidence-based clinical pathway

Multidimensional Scale of Perceived Social Support (MSPSS) in cancer patients: psychometric properties and measurement invariance

Background: The aim of this study was to evaluate the psychometric properties, convergent validity, and factorial invariance of the Multidimensional Scale of Perceived Social Support (MSPSS) in cancer patients. Method: Confi rmatory factor analysis (CFA) was conducted to explore the scale's dimensionality and test for strong measurement invariance across sex and age in a cross-sectional, multicenter, prospective study. Patients completed the MSPSS and Satisfaction with Life Scale (SWLS). Results: A total of 925 consecutive patients were recruited in 13 hospitals between July 2015 and December 2018. The CFA indicated that the original three factor model was replicated in patients with cancer. The results of the multi-group CFA revealed a strong invariance according to sex and age. The Spanish version of the MSPSS had high estimated reliability with values exceeding .90. The simple sum of the items of each scale was a good indicator of oncology patients' perceived social support. The three MSPSS subscales correlated signifi cantly with the SWLS. Women scored higher on social support by friends than men. Conclusion: The Spanish version of the MSPSS proved to be a valid, reliable instrument to assess perceived social support in cancer patients

Correction : Chaparro et al. Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain: Large-Scale Epidemiological Study. J. Clin. Med. 2021, 10, 2885

The authors wish to make the following corrections to this paper [...]

Incidence, Clinical Characteristics and Management of Inflammatory Bowel Disease in Spain : Large-Scale Epidemiological Study

(1) Aims: To assess the incidence of inflammatory bowel disease (IBD) in Spain, to describe the main epidemiological and clinical characteristics at diagnosis and the evolution of the disease, and to explore the use of drug treatments. (2) Methods: Prospective, population-based nationwide registry. Adult patients diagnosed with IBD-Crohn's disease (CD), ulcerative colitis (UC) or IBD unclassified (IBD-U)-during 2017 in Spain were included and were followed-up for 1 year. (3) Results: We identified 3611 incident cases of IBD diagnosed during 2017 in 108 hospitals covering over 22 million inhabitants. The overall incidence (cases/100,000 person-years) was 16 for IBD, 7.5 for CD, 8 for UC, and 0.5 for IBD-U; 53% of patients were male and median age was 43 years (interquartile range = 31-56 years). During a median 12-month follow-up, 34% of patients were treated with systemic steroids, 25% with immunomodulators, 15% with biologics and 5.6% underwent surgery. The percentage of patients under these treatments was significantly higher in CD than UC and IBD-U. Use of systemic steroids and biologics was significantly higher in hospitals with high resources. In total, 28% of patients were hospitalized (35% CD and 22% UC patients, p < 0.01). (4) Conclusion: The incidence of IBD in Spain is rather high and similar to that reported in Northern Europe. IBD patients require substantial therapeutic resources, which are greater in CD and in hospitals with high resources, and much higher than previously reported. One third of patients are hospitalized in the first year after diagnosis and a relevant proportion undergo surgery

Colonial Metaphors: Symbolic Approaches to the Chaco Tierra Adentro

La expresión tierra adentro pertenece al vocabulario de las fuentes coloniales y es también utilizada en el ámbito académico para los estudios de frontera; sin embargo, aún no hemos reflexionado sobre sus usos y sentidos. En este trabajo adopto una perspectiva etnográfica orientada a las fronteras del Chaco durante el siglo XVIII, con la intención de abordar la dimensión simbólica de tierra adentro, atendiendo a los distintos sentidos adheridos a ella durante la Colonia y a las prácticas de dominación asociadas a esas significaciones. Considero, también, su incorporación como categoría de análisis a los estudios académicos sobre los espacios de frontera. Los datos provienen de un gran número de documentos escritos durante la Colonia y fueron examinados desde la propuesta de la antropología histórica: la crítica textual y contextual, la lectura transversal y la interpretación de las situaciones sociales del pasado, entre otras. Tierra adentro condensa un amplio abanico de significados arraigados en el imaginario colonial, que condicionaron la percepción de los grupos indígenas no sometidos y de sus territorios; esos significados ?que se expresan en términos metafóricos? promovieron y habilitaron políticas de sometimiento; el uso de esta expresión en el ámbito académico va de la mano de cierta conceptualización sobre la tierra adentro sobre la que recién se ha comenzado a reflexionar. Este trabajo aporta a la desnaturalización de una expresión habitualmente utilizada, pero sobre cuyos significados intrínsecos aún no se han formulado definiciones ni debates. De esta manera, contribuye a la discusión crítica en cuanto al uso y los alcances teóricos del vocabulario heredado de las fuentes documentales para la investigación histórico-antropológica y propone algunos aspectos comunes que podrían aplicarse a otros espacios concebidos como tierra adentro durante la experiencia colonial.The expression tierra adentro belongs to the language of colonial sources and although it is also used in academia in border studies, we are yet to reflect on its uses and meanings. In this work, I adopt an ethnographic perspective focusing on the frontiers of the Chaco province during the 18th century, in order to address the symbolic dimension of the tierra adentro, paying attention to the different meanings attached to it during the colonial period and the practices of domination associated with those meanings. I also consider its incorporation as a category of analysis in academic border studies. The data come from a large number of documents written during the colonial period, which I examined based on historical anthropology approach: Textual and contextual criticism, transversal reading, and interpretation of past social situations, among others. Tierra adentro condenses a wide range of meanings rooted in the colonial imaginary, which conditioned the perception of non-submissive indigenous groups and their territories; these meanings —expressed in metaphorical terms— promoted and enabled policies of submission. The use of this expression in the academic sphere goes hand in hand with a certain conceptualization of tierra adentro which has only recently begun to be addressed. This work supports the denaturalization of an expression that is commonly used but whose intrinsic meanings have not yet been properly defined or debated. Accordingly, it adds to the critical discussion regarding the use and theoretical scope of the vocabulary acquired from documentary sources for historical-anthropological research and it proposes some common aspects that could be applied to other spaces that were conceived as tierra adentro during the colonial experience.Fil: Lucaioli, Carina Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Sociales. Instituto de Desarrollo Económico y Social. Centro de Investigaciones Sociales; Argentin

Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study

BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8 ml kg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500 ml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg-1 PBW, P &lt; 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P &lt; 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223

Programa de rondas interlaboratorios de análisis de alimentos (PRIDDA): Evaluación del desempeño analítico en el período 1998-2000

En 1998 se diseñó un “Programa de Rondas Interlaboratorios de Análisis de Alimentos” (PRIDDA) para evaluación del desempeño analítico de laboratorios, que se desarrolla en forma continua siguiendo los lineamientos de la Guía ISO/IEC 43-1. En este artículo se analizan los resultados del período 1998-2000, donde participaron hasta 16 laboratorios de Costa Rica, Panamá y Cuba. Se completaron 4 rondas para la evaluación del desempeño en la humedad, grasa, proteína y cenizas, sobre diferentes alimentos (leche en polvo, harinas de trigo, trigo integral y maíz). Cada ronda consistió en la preparación de un material para el análisis, homogéneo y estable, que se distribuyó entre los participantes cada 4 meses. Los laboratorios analizaron los componentes definidos según el alimento, dentro de los 2 meses siguientes, utilizando el método analítico que usualmente aplican. Los resultados y la información sobre el método empleado fueron enviados al coordinador del programa. Este analizó los datos para calcular un estadístico del desempeño (Z), que indica si el resultado obtenido es satisfactorio (|Z|3). La información resultante se presentó a los participantes asegurando confidencialidad. Se recibieron 221 resultados, 156 fueron satisfactorios (71%) y 25 fueron cuestionables (11%). Para los análisis de humedad y grasa se obtuvieron resultados satisfactorios en porcentajes variables (30-82% para humedad y 21-60% en grasa). Esto demuestra la necesidad de que los laboratorios estudien qué fuentes de variación están afectando los resultados. Los porcentajes de resultados satisfactorios de proteína y cenizas obtenidos variaron entre 82 y 100% en ambos casos, lo que indica que los métodos utilizados para estos análisis son poco sensibles a las variaciones en los diferentes parámetros reportados por los laboratorios. La participación de rutina en este tipo de programas es una forma sencilla, objetiva y confiable de controlar la calidad de resultados analíticos, por lo que se espera que este artículo estimule a otros laboratorios a participar.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro Nacional de Ciencia y Tecnología de Alimentos (CITA

Caracterización de la pulpa de banano (Musa cavendishi) inmovilizada como fuente de invertasa

En los países productores de banano se desechan anualmente grandes cantidades de esta fruta. Esta investigación se llevó acaba con el fin de utilizar este desechos como fuente de un sistema enzimático y convertirlas en un producto con alto valor agregado, Se caracterizó la actividad de la invertasa presente en la pulpa de banano inmovilizada en alginato de calcio en forma de perlas, Después de 5 horas de incubación de una solución de sacaros a al 10 con las perlas se logró un 51% de hidrólisis. La relación Perlas-solución de sacarosa más eficiente fue de 1:1. La temperatura óptima de reacción fue de 40°C y el pH óptimo de 4. Baja estas condiciones se observó inhibición por sustrato.UCR::Vicerrectoría de Docencia::Ciencias Agroalimentarias::Facultad de Ciencias Agroalimentarias::Escuela de Tecnología de Alimento