Carnosol Modulates Th17 Cell Differentiation and Microglial Switch in Experimental Autoimmune Encephalomyelitis

Medicinal plants as a rich pool for developing novel small molecule therapeutic medicine have been used for thousands of years. Carnosol as a bioactive diterpene compound originated from Rosmarinus officinalis (Rosemary) and Salvia officinalis, herbs extensively applied in traditional medicine for the treatment of multiple autoimmune diseases (1). In this study, we investigated the therapeutic effects and molecule mechanism of carnosol in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Carnosol treatment significantly alleviated clinical development in the myelin oligodendrocyte glycoprotein (MOG35–55) peptide-induced EAE model, markedly decreased inflammatory cell infiltration into the central nervous system and reduced demyelination. Further, carnosol inhibited Th17 cell differentiation and signal transducer and activator of transcription 3 phosphorylation, and blocked transcription factor NF-κB nuclear translocation. In the passive-EAE model, carnosol treatment also significantly prevented Th17 cell pathogenicity. Moreover, carnosol exerted its therapeutic effects in the chronic stage of EAE, and, remarkably, switched the phenotypes of infiltrated macrophage/microglia. Taken together, our results show that carnosol has enormous potential for development as a therapeutic agent for autoimmune diseases such as MS

Distributed interaction between computer virus and patch: A modeling study

The decentralized patch distribution mechanism holds significant promise as an alternative to its centralized counterpart. For the purpose of accurately evaluating the performance of the decentralized patch distribution mechanism and based on the exact SIPS model that accurately captures the average dynamics of the interaction between viruses and patches, a new virus-patch interacting model, which is known as the generic SIPS model, is proposed. This model subsumes the linear SIPS model. The dynamics of the generic SIPS model is studied comprehensively. In particular, a set of criteria for the final extinction or/and long-term survival of viruses or/and patches are presented. Some conditions for the linear SIPS model to accurately capture the average dynamics of the virus-patch interaction are empirically found. As a consequence, the linear SIPS model can be adopted as a standard model for assessing the performance of the distributed patch distribution mechanism, provided the proper conditions are satisfied

Next-to-leading order QCD corrections to a heavy resonance production and decay into top quark pair at the LHC

We present a complete next-to-leading order (NLO) QCD calculation to a heavy resonance production and decay into a top quark pair at the LHC, where the resonance could be either a Randall-Sundrum (RS) Kaluza-Klein (KK) graviton $G$ or an extra gauge boson $Z'$. The complete NLO QCD corrections can enhance the total cross sections by about $80\%- 100\%$ and $20\%- 40\%$ for the $G$ and the $Z'$, respectively, depending on the resonance mass. We also explore in detail the NLO corrections to the polar angle distributions of the top quark, and our results show that the shapes of the NLO distributions can be different from the leading order (LO) ones for the KK graviton. Moreover, we study the NLO corrections to the spin correlations of the top quark pair production via the above process, and find that the corrections are small.Comment: Published version in PR