Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders

INTRODUCTION: While progress has been made in determining the genetic basis of antisocial behaviour, little progress has been made for antisocial personality disorder (ASPD), a condition that often co-occurs with other psychiatric conditions including substance use disorders, attention deficit hyperactivity disorder (ADHD), and anxiety disorders. This study aims to improve the understanding of the genetic risk for ASPD and its relationship with other disorders and traits. METHODS: We conducted a genome-wide association study (GWAS) of the number of ASPD diagnostic criteria data from 3217 alcohol-dependent participants recruited in the UK (UCL, N = 644) and the USA (Yale-Penn, N = 2573). RESULTS: We identified rs9806493, a chromosome 15 variant, that showed a genome-wide significant association (Z-score = -5.501, P = 3.77 × 10-8) with ASPD criteria. rs9806493 is an eQTL for SLCO3A1 (Solute Carrier Organic Anion Transporter Family Member 3A1), a ubiquitously expressed gene with strong expression in brain regions that include the anterior cingulate and frontal cortices. Polygenic risk score analysis identified positive correlations between ASPD and smoking, ADHD, depression traits, and posttraumatic stress disorder. Negative correlations were observed between ASPD PRS and alcohol intake frequency, reproductive traits, and level of educational attainment. CONCLUSION: This study provides evidence for an association between ASPD risk and SLCO3A1 and provides insight into the genetic architecture and pleiotropic associations of ASPD

Building Local Networks for Open Science: A Case Study of the Chinese Open Science Network (COSN)

The Open Science movement, dedicated to making scientific research more accessible, transparent, and collaborative, faces the challenge of its developed-country origins potentially marginalizing communities in the Global South. This chapter delves into the Chinese Open Science Network (COSN) as a grassroots group pioneering Open Science within the Chinese-speaking community, aiming to bridge the language and cultural divides in science, foster community engagement, and enhance collaboration through digital infrastructures. By focusing on COSN's multifaceted approach, including engaging early-career researchers, utilizing digital platforms for community building, and implementing frugal operation strategies for sustainable development, the chapter highlights COSN's significant contribution towards fostering a more inclusive and collaborative local scientific community. Reflections on COSN's journey reveal four key insights for empowering Open Science practices across the Global South: addressing community-specific needs, emphasizing practical applications, forging diverse partnerships, and maintaining operational affordability. These insights, coupled with COSN's experience in combining resource-sharing with community-building, offer a potential roadmap for other communities aiming to contribute to a more inclusive and equitable research ecosystem. Through a comprehensive analysis, the chapter underscores the importance of grassroots efforts like COSN in bridging the global capacity gap in scientific research and aligns with broader international development objectives. Note: This chapter is set to be published in the "Meta-Research and Development" book, edited by the Meta-Research Team at the Busara Center, with a release planned for mid-2024

Building Local Networks for Open Science:A Case Study of the Chinese Open Science Network (COSN)

The Open Science movement, dedicated to making scientific research more accessible, transparent, and collaborative, faces the challenge of its developed-country origins potentially marginalizing communities in the Global South. This chapter delves into the Chinese Open Science Network (COSN) as a grassroots group pioneering Open Science within the Chinese-speaking community, aiming to bridge the language and cultural divides in science, foster community engagement, and enhance collaboration through digital infrastructures. By focusing on COSN's multifaceted approach, including engaging early-career researchers, utilizing digital platforms for community building, and implementing frugal operation strategies for sustainable development, the chapter highlights COSN's significant contribution towards fostering a more inclusive and collaborative local scientific community. Reflections on COSN's journey reveal four key insights for empowering Open Science practices across the Global South: addressing community-specific needs, emphasizing practical applications, forging diverse partnerships, and maintaining operational affordability. These insights, coupled with COSN's experience in combining resource-sharing with community-building, offer a potential roadmap for other communities aiming to contribute to a more inclusive and equitable research ecosystem. Through a comprehensive analysis, the chapter underscores the importance of grassroots efforts like COSN in bridging the global capacity gap in scientific research and aligns with broader international development objectives

Building Local Networks for Open Science:A Case Study of the Chinese Open Science Network (COSN)

The Open Science movement, dedicated to making scientific research more accessible, transparent, and collaborative, faces the challenge of its developed-country origins potentially marginalizing communities in the Global South. This chapter delves into the Chinese Open Science Network (COSN) as a grassroots group pioneering Open Science within the Chinese-speaking community, aiming to bridge the language and cultural divides in science, foster community engagement, and enhance collaboration through digital infrastructures. By focusing on COSN's multifaceted approach, including engaging early-career researchers, utilizing digital platforms for community building, and implementing frugal operation strategies for sustainable development, the chapter highlights COSN's significant contribution towards fostering a more inclusive and collaborative local scientific community. Reflections on COSN's journey reveal four key insights for empowering Open Science practices across the Global South: addressing community-specific needs, emphasizing practical applications, forging diverse partnerships, and maintaining operational affordability. These insights, coupled with COSN's experience in combining resource-sharing with community-building, offer a potential roadmap for other communities aiming to contribute to a more inclusive and equitable research ecosystem. Through a comprehensive analysis, the chapter underscores the importance of grassroots efforts like COSN in bridging the global capacity gap in scientific research and aligns with broader international development objectives