Activation des réponses immunes par les cellules dendritiques et vaccination antitumorale

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Activation des réponses immunes par les cellules dendritiques et vaccination antitumorale

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Role of B7 costimulation in the induction of T and B cell responses by dendritic cells in vivo

SCOPUS: ar.kinfo:eu-repo/semantics/publishe

Cutaneous infiltrate of chronic lymphocytic leukemia surrounding a primary squamous cell carcinoma of the skin. Report of an additional case and reflection on its pathogenesis [1]

SCOPUS: le.jFLWINinfo:eu-repo/semantics/publishe

Immunohistochemical Identification of Myoepithelial, Epithelial, and Connective Tissue Cells in Canine Mammary Tumors

Fifty-eight formalin-fixed paraffin-embedded canine mammary tumors, 19 malignant and 39 benign, were used in this study. Tumors were obtained from dogs submitted for surgical resection of lesions at private veterinary practices in Brussels or from the surgery unit of the Faculty of Veterinary Medicine, University of Liège. Immunohistochemical evaluation was performed, using monoclonal antibodies directed against keratins 8–18 and 19, vimentin, desmin, and α-actin and polyclonal antibodies directed against high-molecular-weight keratins and S-100 protein. The main cell types, epithelial, myoepithelial, and connective, were identified, and myoepithelial cells represented the major component of most tumors, both benign and malignant. Myoepithelial cells had five patterns: resting and proliferative suprabasal cells, spindle and star-shaped interstitial cells, and cartilage. Reactivity to keratin 19, vimentin, α-actin, and S-100 protein suggested a progressive transformation from resting cells to cartilage. Epithelial cell reactivities were limited to keratins; only keratinized cells were positive for polyclonal keratins. Myofibroblasts were positive for both vimentin and α-actin, and connective tissue cells were positive for vimentin. Myoepithelial cells appeared to be the major component of carcinomas, justifying reevaluation and simplification of histomorphologic classifications, with a “pleomorphic carcinoma” group including all carcinomas except squamous, mucinous, and comedo carcinomas. Immunohistochemical evaluation, in addition to routine hematoxylin and eosin histopathologic evaluation is recommended for precise classification of canine mammary tumors. © 1993, American College of Veterinary Pathologists. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Fonction et maturation des cellules dendritiques in vivo

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Adhesion molecule profiles in atopic dermatitis vs. allergic contact dermatitis: Pharmacological modulation by cetirizine

Background. Experimental data suggest that there is an imbalance between Th1 and Th2 cells in atopic dermatitis (AD) skin compared to allergic contact dermatitis (ACD). This imbalance (Th2 and Th1 predominance, respectively) implies the production of different cytokines in these two conditions leading to different expression of adhesion molecules on skin endothelial cells. Objective. The expression of VCAM-1 (IL-4/Th2-dependent) and ICAM-1 (INF-γ/IL-1) on dermal vessels was compared in six patients with AD and six patients with ACD. The effect of cetirizine, a highly selective H1-receptor antagonist on the expressions was studied. Methods. Six patients with AD were challenged with Dermatophagoides pteronyssimus (DPT patch tests applied to clinically normal skin) and six patients with ACD challenged in the same way with allergens of the European standard series. Skin biopsies at challenged sites were performed before and 6, 24 and 48 h after challenge. The experiment was carried out under double-blind cross-over conditions during a 4-day treatment with a placebo and cetirizine. Results. In AD patients, the scores for both VCAM-1 and ICAM-1 were high before and after challenge. In ACD patients, the ICAM-1 score was high at each experimental time, but the VCAM-1 score, which was significantly lower before challenge, increased at 6, 24 and 48 h after challenge. The administration of cetirizine significantly reduced the VCAM-1 expression in AD patients at each experimental time. Conclusion. It is concluded that the increased VCAM-1 expression in AD patients compared to ACD may reflect greater IL-4 and/or IL-13 production in situ. The study also confirms the existence of a modulating effect of cetirizine in vivo on adhesion molecule expression.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe

Langherhan’s cell histiocytosis associated with simultaneous lymphocyte predominance hodgkin’s disease and malignant melanoma

info:eu-repo/semantics/publishe

Development of a calcifying fibrous pseudotumour within a lesion of Castleman disease, hyaline-vascular subtype

A nine year old boy with localised Castleman disease of the hyaline- vascular subtype developed a calcifying fibrous pseudotumour. This pathological association does not appear to have been described before. In this case, the development of this very unusual soft tissue tumour-like process was thought to be related to a previous fine needle aspiration biopsy, which was performed because of lymphadenopathy localised to the right inguinal area. This case provides further evidence of the reactive nature of calcifying fibrous pseudotumour and also broadens the pathological spectrum of the stromal cell proliferation that occasionally supervenes within lesions of Castleman disease, hyaline-vascular type.SCOPUS: ar.jinfo:eu-repo/semantics/publishe