27 research outputs found
Factors associated with loss of white matter anisotropy in post-treatment medulloblastoma survivors
We evaluate effects of age at cranial irradiation, time interval since irradiation and irradiation dose on white matter anisotropy in childhood medulloblastoma
survivors by computing white matter fractional anisotropy (WM FA) using SPM post-processing functions. Mean percentage change in WM FA of patients
compared to controls was -4.4% (sd=7.6%). Using Spearmanís correlation, there were significant associations between percentage reduction of WM FA and
age at cranial irradiation (r=0.673, p=0.002) and irradiation dose (r=-0.723, p=<0.001), but not with time interval since irradiation. Multivariate regression
analysis confirmed that both factors correlated significantly with percentage reduction of WM FA (adjusted r2=0.516, p=0.001).published_or_final_versio