Electron and phonon band-structure calculations for the antipolar SrPt3_{3}P antiperovskite superconductor: Evidence of low-energy two-dimensional phonons

SrPt3P has recently been reported to exhibit superconductivity with Tc = 8.4 K. To explore its superconducting mechanism, we have performed electron and phonon band calculations based on the density functional theory, and found that the superconductivity in SrPt3P is well described by the strong coupling phonon-mediated mechanism. We have demonstrated that superconducting charge carriers come from pd\pi-hybridized bands between Pt and P ions, which couple to low energy (~ 5 meV) phonon modes confined on the ab in-plane. These in-plane phonon modes, which do not break antipolar nature of SrPt3P, enhance both the electron-phonon coupling constant \lambda and the critical temperature Tc. There is no hint of a specific phonon softening feature in the phonon dispersion, and the effect of the spin-orbit coupling on the superconductivity is found to be negligible.Comment: 5 pages, 5 figures, 1 tabl

New insights into guidance laws with terminal angle constraints

Introduction : In the field of guidance technology, advanced guidance laws are being developed using various control theories such as optimal control [1,2], sliding mode control [3–6], H-infinity control [7], the state-dependent Riccati equation [8], the Lyapunov theory [9], the geometric control theory [10], predictive control [11,12], and feedback linearization control [13]. The general procedure of this approach is to first establish the guidance problem to be solved and to define the guidance geometry and kinematics equation corresponding to the guidance problem. A guidance law is then systematically designed in such a way that an appropriate control theory is applied to a predetermined guidance problem. The potential importance of this approach is that a number of advanced guidance laws can be newly developed, depending on the combinations of guidance problems and control theories. Therefore, recent trends in the design of guidance laws focus on finding a new combination of guidance problems and control theory to obtain a new guidance law that is superior to the conventional guidance law. Although previous research has focused more on the methodology and the design process itself, little effort has been made toward understanding the characteristics of the newly developed guidance laws

Significance of EpCAM and TROP2 expression in non-small cell lung cancer

<p>Abstract</p> <p>Background</p> <p>The tumor-associated calcium signal transducer (<it>TACSTD</it>) genes, originally designated epithelial cell adhesion molecule (EpCAM) and TROP2, represent true oncogenes. Little is known about EpCAM and TROP2 gene expression in non-small cell lung carcinoma (NSCLC). This study evaluated EpCAM and TROP2 protein expression and clinicopathologic significance in cases of NSCLC.</p> <p>Methods</p> <p>Tissue microarray blocks acquired from 164 cases of NSCLC, including 100 cases of adenocarcinoma (AdC) and 64 of squamous cell carcinoma (SCC), were examined by immunohistochemical staining for EpCAM, and TROP2. The results were correlated with clinicopathologic data.</p> <p>Results</p> <p>EpCAM and TROP2 were significantly overexpressed in SCC than in AdC (<it>P </it>< 0.01). In AdC, EpCAM overexpression was closely related to sex, histologic grade, pathologic T stage, pathologic N stage, and TNM stage, and TROP2 overexpression was only related to histologic grade (<it>P </it>< 0.05, respectively). In SCC, correlations were evident between EpCAM overexpression and TNM stage (<it>P </it>= 0.01), and between TROP2 overexpression and pathologic T stage (<it>P </it>= 0.02). EpCAM overexpression showed no significance with overall survival in AdC and SCC patients. However, TROP2 overexpression in AdC had a positive influence on overall survival (<it>P </it>= 0.02) and disease-free survival (<it>P </it>= 0.03). In particular, AdC patients with stage II or III showed better overall survival (<it>P </it>= 0.05) and disease-free survival (<it>P </it>= 0.04).</p> <p>Conclusions</p> <p>While EpCAM and TROP2 show weak and non-complete membranous staining in normal bronchial epithelium and pneumocyte, their complete membranous expression in carcinoma suggests their role in carcinogenesis. EpCAM and TROP2 were more frequently overexpressed in SCC. EpCAM overexpression had no prognostic value in this study, but TROP2 overexpression showed better survival in AdC patients and might be a better prognostic marker in advanced stage AdC.</p