Fire-cracked Rock Use and Reuse in the Hueco Bolson, Fort Bliss, Texas

The Center for Archaeological Research of The University of Texas at San Antonio conducted an analysis of 29,058 pieces of fire-cracked rock and burned caliche selected from a sample of hundreds of features tested as part of the Hueco Mountain Archaeological Project at Fort Bliss, Texas. Feature and non-feature material included in this analysis were collected from site FB 13237 located on the proximal fan, FB 12719 within the basin area, and FB 12412 situated in the transitional zone between the two. The goal of the analysis was to identify patterns of attribute variability in burned rock that could be used to infer function of the various features and sites in the sample. Specific burned rock attributes used in the study were material type, size, weight, and the presence or absence of fracturing, cortex, and discoloration. These attributes were recorded and compared in various combinations at course- and fme-grained levels of intensity to address issues of reuse, recycling, feature function, thermally induced morphological variability, and how these variables might relate to specific land forms through time. Through these comparisons, patterns relating to expedient material selection, feature type, reuse and feature function were identified

Test Excavations at the Culebra Creek Site, 41BX126, Bexar County, Texas

Archaeological test excavations were undertaken at 4IBX126 on Culebra Creek to offset the impact from a proposed Texas Department of Transportation (TxDOT) highway improvement project on Loop 1604 in northwest Bexar County. Archaeological investigations were conducted in three field seasons: the first two seasons were conducted by TxDOT archaeologists and the third was directed by personnel from the Center for Archaeological Research (CAR) of The University of Texas at San Antonio. During the three projects, 55 hand-dug units, 29 backhoe trenches, 36 shovel tests, and eight Gradall trenches were excavated. Seventeen features were recorded; 25 radiocarbon assays were conducted; over 59,000 lithic artifacts were recovered and analyzed; 1,655 liters of sediment float samples were processed; 3,337 kg of burned rock were analyzed; and nearly 300 g of fatmal material and 25 archaeomagnetic samples were analyzed. The testing revealed utilization of the site in the Early, Middle, and Late Archaic periods. The analysis of materials and results of all three field efforts are presented in this single volume. Geoarchaeological investigations show that four terraces (TO, Tl, T2, and T3) in the immediate site area accumulated from the Late Pleistocene through the Holocene. Five Stratigraphic Units (I-V) make up these terraces and overlap one another. The T2 terrace is composed of Stratigraphic Units IT, ill, and IV, while the Tl terrace consists mostly of Stratigraphic Units IV and V. Archaeological materials were discovered in situ within the Tl and T3 terraces and primarily within Stratigraphic Units ill and IV. Radiocarbon assays indicate that Stratigraphic Unit IV formed between at least 4000-2000 B.P., Stratigraphic Unit ill accumulated between approximately 11,500-4000 B.P., and Stratigraphic Unit IT was accreting at least 17,500 years ago. Too little evidence exists to determine the full time ranges of sediment accumulation, and whether significant temporal gaps exist between the sedimentation of these geological units. Archaeological excavations focused on three separate areas: A, B, and C. Area A is a new right-of-way east of the existing right-of-way. Excavations in this area defined a Late Archaic Montell component dating to approximately 2700 B.P. These materials include two burned rock features in situ within Unit IV on the scarp of the T2 terrace. This area probably was occupied by a small residential group during the Late Archaic period. Area B is east of Loop 1604 in the existing right-of-way and on the T2 terrace. Area B contains a Middle Archaic Nolan component in the upper portion of Stratigraphic Unit ill, below a Late Archaic burned rock midden with a central subsurface oven in Unit IV. Area C is in the existing right-of-way west of Loop 1604. Excavations in this area investigated the possibility of an intact Early Archaic occupation; however, no evidence of one was found. In Area B, the Nolan component consisted of lithic artifacts scattered among small burned rock features that probably served as hearths. This component is radiocarbon dated to approximately 4600 B.P. The Late Archaic burned rock midden was apparently used between 4000 B.P. and 2000 B.P. Subfeatures within the central oven indicate multiple cooking events. Ethnographic evidence suggests earth ovens contained food wrapped with insulating material over a layer of hot rocks heated by a coal bed. This was capped with dirt to seal the oven. When cooking was complete, the earth cap is removed to reach the food. CAR conducted earth-oven hot-rock experiments which indicated that local limestone could be used once or at the most twice. Local hot-rock cooking should generate a great deal of burned limestone debris. The framework ofthe feature at 41BX126 represents the cap and rock heating-element dumpings from separate cooking events as well as a few small intact burned rock features that served as ovens or hearths. At the base of the midden were a few depressions that may represent borrow pits used to obtain sediment for the central oven cap. Mixing of temporally distinct artifacts from the Nolan and later occupations occurs in and beyond the midden due to sediment excavation and transportation across the site, and redeposition of materials through erosion of materials off the framework

Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer.

The introduction of serum Prostate Specific Antigen (PSA) testing nearly 30 years ago has been associated with a significant shift towards localized disease and decreased deaths due to prostate cancer. Recognition that PSA testing has caused over diagnosis and over treatment of prostate cancer has generated considerable controversy over its value, and has spurred efforts to identify prognostic biomarkers to distinguish patients who need treatment from those that can be observed. Recent studies show that cancer is heterogeneous and forms a hierarchy of tumor cell populations. We developed a method of identifying prostate cancer differentiation states related to androgen signaling using Boolean logic. Using gene expression data, we identified two markers, CD38 and ARG2, that group prostate cancer into three differentiation states. Cancers with CD38-, ARG2- expression patterns, corresponding to an undifferentiated state, had significantly lower 10-year recurrence-free survival compared to the most differentiated group (CD38+ARG2+). We carried out immunohistochemical (IHC) staining for these two markers in a single institution (Stanford; n = 234) and multi-institution (Canary; n = 1326) cohorts. IHC staining for CD38 and ARG2 in the Stanford cohort demonstrated that combined expression of CD38 and ARG2 was prognostic. In the Canary cohort, low CD38 protein expression by IHC was significantly associated with recurrence-free survival (RFS), seminal vesicle invasion (SVI), extra-capsular extension (ECE) in univariable analysis. In multivariable analysis, ARG2 and CD38 IHC staining results were not independently associated with RFS, overall survival, or disease-specific survival after adjusting for other factors including SVI, ECE, Gleason score, pre-operative PSA, and surgical margins

Links between environment, diet, and the hunter-gatherer microbiome

The study of traditional populations provides a view of human-associated microbes unperturbed by industrialization, as well as a window into the microbiota that co-evolved with humans. Here we discuss our recent work characterizing the microbiota from the Hadza hunter-gatherers of Tanzania. We found seasonal shifts in bacterial taxa, diversity, and carbohydrate utilization by the microbiota. When compared to the microbiota composition from other populations around the world, the Hadza microbiota shares bacterial families with other traditional societies that are rare or absent from microbiotas of industrialized nations. We present additional observations from the Hadza microbiota and their lifestyle and environment, including microbes detected on hands, water, and animal sources, how the microbiota varies with sex and age, and the short-term effects of introducing agricultural products into the diet. In the context of our previously published findings and of these additional observations, we discuss a path forward for future work

Software systems for operation, control, and monitoring of the EBEX instrument

We present the hardware and software systems implementing autonomous operation, distributed real-time monitoring, and control for the EBEX instrument. EBEX is a NASA-funded balloon-borne microwave polarimeter designed for a 14 day Antarctic flight that circumnavigates the pole. To meet its science goals the EBEX instrument autonomously executes several tasks in parallel: it collects attitude data and maintains pointing control in order to adhere to an observing schedule; tunes and operates up to 1920 TES bolometers and 120 SQUID amplifiers controlled by as many as 30 embedded computers; coordinates and dispatches jobs across an onboard computer network to manage this detector readout system; logs over 3~GiB/hour of science and housekeeping data to an onboard disk storage array; responds to a variety of commands and exogenous events; and downlinks multiple heterogeneous data streams representing a selected subset of the total logged data. Most of the systems implementing these functions have been tested during a recent engineering flight of the payload, and have proven to meet the target requirements. The EBEX ground segment couples uplink and downlink hardware to a client-server software stack, enabling real-time monitoring and command responsibility to be distributed across the public internet or other standard computer networks. Using the emerging dirfile standard as a uniform intermediate data format, a variety of front end programs provide access to different components and views of the downlinked data products. This distributed architecture was demonstrated operating across multiple widely dispersed sites prior to and during the EBEX engineering flight.Comment: 11 pages, to appear in Proceedings of SPIE Astronomical Telescopes and Instrumentation 2010; adjusted metadata for arXiv submissio

EBEX: A balloon-borne CMB polarization experiment

EBEX is a NASA-funded balloon-borne experiment designed to measure the polarization of the cosmic microwave background (CMB). Observations will be made using 1432 transition edge sensor (TES) bolometric detectors read out with frequency multiplexed SQuIDs. EBEX will observe in three frequency bands centered at 150, 250, and 410 GHz, with 768, 384, and 280 detectors in each band, respectively. This broad frequency coverage is designed to provide valuable information about polarized foreground signals from dust. The polarized sky signals will be modulated with an achromatic half wave plate (AHWP) rotating on a superconducting magnetic bearing (SMB) and analyzed with a fixed wire grid polarizer. EBEX will observe a patch covering ~1% of the sky with 8' resolution, allowing for observation of the angular power spectrum from \ell = 20 to 1000. This will allow EBEX to search for both the primordial B-mode signal predicted by inflation and the anticipated lensing B-mode signal. Calculations to predict EBEX constraints on r using expected noise levels show that, for a likelihood centered around zero and with negligible foregrounds, 99% of the area falls below r = 0.035. This value increases by a factor of 1.6 after a process of foreground subtraction. This estimate does not include systematic uncertainties. An engineering flight was launched in June, 2009, from Ft. Sumner, NM, and the long duration science flight in Antarctica is planned for 2011. These proceedings describe the EBEX instrument and the North American engineering flight.Comment: 12 pages, 9 figures, Conference proceedings for SPIE Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy V (2010

Nonlinear Optics: The Enabling Technology for Quantum Information Science

Nonlinear optical processes such as parametric down conversion and squeezed light generation are key elements of most quantum protocols, leading to crucial applications such as quantum imaging, sub-shot-noise metrology, and secure communication