Leadership Identity Development in Greek Life Organizations: Lessons Learned

This study focused on the multi-faceted process of leadership identity development through an-in dpeth analyis of the life experiences of students involved in Greek life at a mid-size researched institution in the Souther United States region. Research was conducted within the framerwork of the Leadership Identity Development (LID) model authored by Komives, Owen, Longerbem, Mainella, and Osteen (2005). Of particular interest was the degree to which the data upheld the presence of the four development influences of the LID model : 1) peer influences 2) meaningful involvement 3) reflective learning and 4) adult influence.Framed by an understanding of college student development and emerging explanatations of the process of leadership identity development, the qualitiative study examined the influence of fraternity and sorority membership on the leadership identity development of college students. The findings derived from semi-structure interviews with fraternity and sorority leaders illustrate the context and cultures in which the particapants develop an identity as an leader. In addition, the study describes the processes and experiences that facilitate or hinder development.Nominated by student affairs professionals, twelve undergraduate fraternity and sorority members at one southern U.S. research institution particapated in the study. The findings suggest organizational factors and meaningful relationships support leader identity development ofr fraternity and sorority members. The study also suggests advancing practical applications of the theoretical construct of leadership identity development. The study concludes with recommendations for program development, practice, and further research

Integrative analysis of drug response and clinical outcome in acute myeloid leukemia

Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and clinical annotations for a large cohort of AML patients, which facilitated discovery of functional genomic correlates. Here, we present a dataset that has been harmonized with our initial report to yield a cumulative cohort of 805 patients (942 specimens). We show strong cross-cohort concordance and identify features of drug response. Further, deconvoluting transcriptomic data shows that drug sensitivity is governed broadly by AML cell differentiation state, sometimes conditionally affecting other correlates of response. Finally, modeling of clinical outcome reveals a single gene, PEAR1, to be among the strongest predictors of patient survival, especially for young patients. Collectively, this report expands a large functional genomic resource, offers avenues for mechanistic exploration and drug development, and reveals tools for predicting outcome in AML. [Display omitted] •Acute myeloid leukemia patient cohort with clinical, molecular, drug response data•Validation and discovery of diverse biological features of drug response•Broad mapping of tumor cell differentiation state affecting response to drugs•Modeling reveals a strong and targetable determinant of clinical outcome Bottomly et al. present a functional genomic resource composed of molecular, clinical, and drug response data on acute myeloid leukemia patient specimens. Through integration of all of these data, they identify genetic and cell differentiation state features that predict drug response, and they utilize modeling to identify targetable determinants of clinical outcome