Resting-state abnormalities in amnestic mild cognitive impairment: a meta-analysis

published_or_final_versio

Moderating Effects of Cortisol on Neural-Cognitive Association in Cognitively Normal Elderly Subjects

published_or_final_versio

Ketanserin attenuates cigarette-mediated oxidative stress in human bronchial epithelial cells

published_or_final_versionThe 15th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 16 January 2010. In Hong Kong Medical Journal, 2010, v. 16, suppl. 1, p. 34, abstract no. 5

Roles of endothelin-1 in beta-amyloid-induced neurotoxicity in hippocampus: an implication for Alzheimer’s pathology

Poster F - Nervous System Disorders: abstract no. P3-F-012The British Neuroscience Association’s Festival of NeuroscienceAlzheimer’s disease (AD) is an incurable neurodegenerative disorder. Abnormal levels of endothelin-1 (ET-1) have been demonstrated in parietal white matter(1), cerebral cortex and vessels of the AD brain(2). Neuronal death and accumulation of beta-amyloid (Aβ) are prominent pathological features of AD. Significant neuronal death is found in Aβ-treated primary neurons and Aβ-overexpressing mouse models(3,4). ET-1 is a known vasoconstrictor and neuro-active peptide. ET-1 induces apoptosis in primary retinal neurons(5). In contrary, ET-receptor (ETR) type B agonist can rescue neurons from Aβ-induced apoptosis(6). These findings suggest ET-1 plays dual roles in neurodegeneration and neuroprotection, respectively. This study aims to investigate the effect of ET-1 on Aβ-induced cell death in hippocampal neurons. Primary hippocampal neurons were pretreated with or without ETR antagonists prior to the treatment of oligomeric form of Aβ1-42, ET-1 or both on 14 DIV. Cell viability was measured by MTT assay. Changes in protein expression in apoptotic and ET-1 signaling pathways were assessed by western-blot analysis. This study shed light on the roles of ET-1 in Aβ1-42-neurotoxicity, building upon which the ET-1 signaling pathway as a potential therapeutic target for AD can be further investigated.published_or_final_versio

Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease.

postprin

Long live the brain: can dementia be defeated by looking beyong the current "Alzheimer's disease myth"?

Scientific Sessio

A discussion on approaches to tackle Alzheimer's disease

Conference Theme: Cultural Diversity, Social Change and Mental Health in ChinaThe International Conference on Transcultural Psychiatry: Cultural Diversity, Social Change and Mental Health in China, Shanghai, China, 18-20 April 2010

Alzheimer's disease through the eyes of a psychiatrist

Session G: Clinical studies and trials in Alzheimer's DiseaseConference Theme: From Public Health, Basic and Clinical Sciences to Therapeutic Insight

Long live the brain: the puzzle, the work, and the direction

1. Healthy Aging : Scientific Meeting of the Research Centre of Heart, Brain, Hormone and Healthy Aging - Morning Parallel Session: Keynote Lecture IIIThe Conference program's website is located at http://www.med.hku.hk/fbr2010/programme.htmlConferenceTheme: Achieving Excellence through multi-disciplinary Researc