The Intensities of Cosmic Ray H and He Nuclei at ~250 MeV/nuc Measured by Voyagers 1 and 2 - Using these Intensities to Determine the Solar Modulation Parameter in the Inner Heliosphere and the Heliosheath Over a 40 Year Time Period

We have determined the solar modulation potential, phi, vs. time that is observed at Voyager 1 and 2 from measurements of the H and He nuclei intensities at a common energy of 250 MeVnuc. The H nuclei have a rigidity 0.7 GV, the He nuclei 1.4 GV. These measurements cover a 40 year time period, which includes almost 4 cycles of solar 11 year sunspot variations, throughout the inner heliosphere out to the HTS at distances of 95 AU and 85 AU, respectively at V1 and V2, and then beyond in the heliosheath. Inside the HTS the modulation potential vs. time curves at V1 and V2 show a very similar temporal structure to those observed at the Earth. During a later period of maximum solar modulation from 2000.0 to 2005.0 when V1 and V2 are in the outer heliosphere between 60-94 AU, the main temporal features of the modulation potential curves at all 3 locations match up with appropriate time delays at V1 and V2 if it is assumed that spatially coherent structures are moving outward past V1 and V2, with outward speeds of up to 700 Kms negative 1. After 2004.0 V1 and V2 are at latitudes of positive 35 and negative 30 respectively, placing lower limits on the latitude extent of these structures. Beyond the HTS in the heliosheath the modulation potential slowly decreases at both spacecraft with only a weak evidence of the unusual modulation minimum observed at the Earth in 2009, for example. A sudden decrease of the modulation potential 50 MV for both H and He nuclei occurs at V1 just before the heliopause crossing at about 122 AU. This decrease has not yet been observed at V2, which is now at 113 AU and still observing a modulation potential 60 MV.Comment: 28 pages, 9 Figure

Termination shock particle spectral features

Spectral features of energetic H ions accelerated at the termination shock may be evidence of two components. At low energies the energy spectrum is ~E^(–1.55), with break at ~0.4 MeV to E^(–2.2). A second component appears above ~1 MeV with a spectrum of E^(–1.27) with a break at ~3.2 MeV. Even though the intensities upstream are highly variable, the same spectral break energies are observed, suggesting that these are durable features of the source spectrum. The acceleration processes for the two components may differ, with the lower energy component serving as the injection source for diffusive shock acceleration of the higher energy component. Alternatively, the spectral features may result from the energy dependence of the diffusion tensor that affects the threshold for diffusive shock acceleration

Voyager observations of galactic and anomalous cosmic rays in the helioshealth

Anomalous cosmic rays display large temporal variations at the time and location where Voyager 1 (V1) crossed the heliospheric termination shock (2004.86) (94AU, 34°N). On a short time scale (3 months) there was a large decrease produced by a series of merged interaction regions (MIR), the first of which was associated with the intense Oct./Nov. 2003 solar events. On a longer time scale there is a remarkable correlation between changes in the galactic cosmic ray (GCR) intensity and those of 10–56 MeV/n ACR He and 30–56 MeV H extending over a 4.3 year period with the GCRs exhibiting their expected behavior over this part of the 11 and 22 year solar activity and heliomagnetic cycle. The relative changes in the ACR and GCR are the same for both the short term and long term variations. The comparative V1/V2 ACR and GCR spectra in the foreshock and heliosheath indicate that at this time most of the higher energy ACRs are not being accelerated near V1 but must have their source region elsewhere — possibly near the equatorial region of the TS as was suggested in our first paper on the TS crossing (1)

Transient intensity changes of cosmic rays beyond the heliospheric termination shock as observed at Voyager 1

This paper continues our studies of temporal variations of cosmic rays beyond the heliospheric termination shock (HTS) using Voyager 1 (V1) data when V1 was beyond 94 AU. This new study utilizes cosmic ray protons and electrons of several energies. Notable transient decreases of 5–50% are observed in galactic cosmic ray nuclei and electrons at V1 shortly after similar decreases are observed at Voyager 2 (V2) still inside the HTS. These decreases at V1 appear to be related to the large solar events in September 2005 and December 2006 and the resulting outward moving interplanetary shock. These two large interplanetary shocks were the largest observed at V2 after V1 crossed the HTS at the end of 2004. They were observed at V2 just inside the HTS at 2006.16 and 2007.43 providing timing markers for V1. From the timing of the intensity decreases observed at V1 as the shocks first reach the HTS and then later reach V1 itself, we can estimate the shock speed beyond the HTS to be between 240 and 300 km s^(−1) in both cases. From the timing of the decreases observed when the shock first reaches the HTS and then several months later encounters the heliopause, we can estimate the heliosheath thickness to be 31 ± 4 and 37 ± 6 AU, respectively, for the two sequences of three decreases seen at V1. These values, along with the distances to the HTS that are determined, give distances from the Sun to the heliopause of 121 ± 4 and 124 ± 6 AU, respectively

At Voyager 1 Starting on about August 25, 2012 at a Distance of 121.7 AU From the Sun, a Sudden Disappearance of Anomalous Cosmic Rays and an Unusually Large Sudden Increase of Galactic Cosmic Ray H and He Nuclei and Electron Occurred

At the Voyager 1 spacecraft in the outer heliosphere, after a series of complex intensity changes starting at about May 8th, the intensities of both anomalous cosmic rays (ACR) and galactic cosmic rays (GCR) changed suddenly and decisively on August 25th (121.7 AU from the Sun). The ACR started the intensity decrease with an initial e-folding rate of intensity decrease of ~1 day. Within a matter of a few days, the intensity of 1.9-2.7 MeV protons and helium nuclei had decreased to less than 0.1 of their previous value and after a few weeks, corresponding to the outward movement of V1 by ~0.1 AU, these intensities had decreased by factors of at least 300-500 and are now lower than most estimates of the GCR spectrum for these lower energies and also at higher energies. The decrease was accompanied by large rigidity dependent anisotropies in addition to the extraordinary rapidity of the intensity changes. Also on August 25th the GCR protons, helium and heavier nuclei as well as electrons increased suddenly with the intensities of electrons reaching levels ~30-50% higher than observed just one day earlier. This increase for GCR occurred over ~1 day for the lowest rigidity electrons, and several days for the higher rigidity nuclei of rigidity ~0.5-1.0 GV. After reaching these higher levels the intensities of the GCR of all energies from 2 to 400 MeV have remained essentially constant with intensity levels and spectra that may represent the local GCR. These intensity changes will be presented in more detail in this, and future articles, as this story unfolds.Comment: 13 Pages, 5 Figure

Large periodic time variations of termination shock particles between ~0.5-20 mev and 6-14 mev electrons measured by the crs experiment on Voyager 2 as it crossed into the heliosheath in 2007: An example of freshly accelerated cosmic rays?

We have examined features in the structure of the heliosheath using the fine scale time variations of termination shock particles (TSP) between ~0.5 - 20 MeV and electrons between 2.5-14 MeV measured by the CRS instrument as the V2 spacecraft crossed the heliospheric termination shock in 2007. The very disturbed heliosheath at V2 is particularly noteworthy for strong periodic intensity variations of the TSP just after V2 crossed the termination shock (2007.66) reaching a maximum between 2007.75 and 2008.0. A series of 42/21 day periodicities was observed at V2 along with spectral changes of low energy TSP and the acceleration of 6-14 MeV electrons. Evidence is presented for the acceleration of TSP and electrons at the times of the 42/21 day periodicities just after V2 crossed the HTS. Spectra for TSP between 2-20 MeV and electrons between 2.5-14 MeV are derived for three time periods including the time of the HTS crossing. The energy spectra of TSP and electrons at these times of intensity peaks are very similar above ~3 MeV, with exponents of a power law spectrum between -3.0 and -3.6. The ratio of TSP intensities to electron intensities at the same energy is ~500. The electron intensity peaks and minima are generally out of phase with those of nuclei by ~1/2 of a 42 day cycle. These charge dependent intensity differences and the large periodic intensity changes could provide new clues as to a possible acceleration mechanism

Anomalous cosmic rays in the heliosheath

We report on Voyager 1 and 2 observations of anomalous cosmic rays in the outer heliosphere. The energy spectrum of anomalous cosmic ray helium as each spacecraft crossed the solar wind termination shock into the heliosheath remained modulated. Assuming the intensity gradient between the two spacecraft is purely radial, we find that radial gradients in the heliosheath of He with 11.6–22.3 MeV/nuc and with ∼61–73MeV/nuc∼61–73 MeV/nuc are 4.9±1.2%/AU4.9±1.2%/AU and 0.0±0.5%/AU,0.0±0.5%/AU, respectively. Strong temporal variations of the 11.6–22.3 MeV/nuc He intensity at both spacecraft were observed in 2005 just after Voyager 1 crossed the termination shock and while Voyager 2 was upstream. After 2006.0, the intensity variations are more moderate and likely due to a combination of spatial and temporal variations. As of early 2008, the anomalous cosmic ray He energy spectrum has unfolded to what may be a source spectrum. The spectrum at Voyager 2 remains modulated. We examine three recent models of the origin of anomalous cosmic rays in light of these observations

Nitrous oxide emissions from the Arabian Sea: A synthesis

We computed high-resolution (1º latitude x 1º longitude) seasonal and annual nitrous oxide (N2O) concentration fields for the Arabian Sea surface layer using a database containing more than 2400 values measured between December 1977 and July 1997. N2O concentrations are highest during the southwest (SW) monsoon along the southern Indian continental shelf. Annual emissions range from 0.33 to 0.70 Tg N2O and are dominated by fluxes from coastal regions during the SW and northeast monsoons. Our revised estimate for the annual N2O flux from the Arabian Sea is much more tightly constrained than the previous consensus derived using averaged in-situ data from a smaller number of studies. However, the tendency to focus on measurements in locally restricted features in combination with insufficient seasonal data coverage leads to considerable uncertainties of the concentration fields and thus in the flux estimates, especially in the coastal zones of the northern and eastern Arabian Sea. The overall mean relative error of the annual N2O emissions from the Arabian Sea was estimated to be at least 65%

PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation.

A new approach to the management of non-small-cell lung cancer (NSCLC) has recently emerged that works by manipulating the immune checkpoint controlled by programmed death receptor 1 (PD-1) and its ligand programmed death ligand 1 (PD-L1). Several drugs targeting PD-1 (pembrolizumab and nivolumab) or PD-L1 (atezolizumab, durvalumab, and avelumab) have been approved or are in the late stages of development. Inevitably, the introduction of these drugs will put pressure on healthcare systems, and there is a need to stratify patients to identify those who are most likely to benefit from such treatment. There is evidence that responsiveness to PD-1 inhibitors may be predicted by expression of PD-L1 on neoplastic cells. Hence, there is considerable interest in using PD-L1 immunohistochemical staining to guide the use of PD-1-targeted treatments in patients with NSCLC. This article reviews the current knowledge about PD-L1 testing, and identifies current research requirements. Key factors to consider include the source and timing of sample collection, pre-analytical steps (sample tracking, fixation, tissue processing, sectioning, and tissue prioritization), analytical decisions (choice of biomarker assay/kit and automated staining platform, with verification of standardized assays or validation of laboratory-devised techniques, internal and external quality assurance, and audit), and reporting and interpretation of the results. This review addresses the need for integration of PD-L1 immunohistochemistry with other tests as part of locally agreed pathways and protocols. There remain areas of uncertainty, and guidance should be updated regularly as new information becomes available