Suppression of myocardial fibrosis by valsartan and monopril in animals after acute myocardial infarction

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Expression of Cyclooxygenase-2 Protein in Acute Myocardial Infarction

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Elevation of marcophage migration inhibitory factor level acute myocardial infarction but not in acute myocardial ischaemia

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Memory acquisition: A 2-Take approach

When more and more people recognize the value of volatile data, live forensics gains more weight in digital forensics. It is often used in parallel with traditional pull-the-plug forensics to provide a more reliable result in forensic examination. One of the core components in live forensics is the collection and analysis of memory volatile data, during which the memory content is acquired for searching of relevant evidential data or investigating various computer processes to unveil the activities being performed by a user. However, this conventional method may have weaknesses because of the volatile nature of memory data and the absence of original data for validation. This may cause implication to the admissibility of memory data at the court of law which requires strict authenticity and reliability of evidence. In this paper, we discuss the impact of various memory acquisition methods and suggest a 2-Take approach which aims to enhance the confidence level of the acquired memory data for legal proceedings. © 2009 IEEE.published_or_final_versionThe 2009 International Workshop on Forensics for Future Generation Communication Environments (F2GC-09) in conjunction with CSA 2009, Jeju Island, Korea, 10-12 December 2009. In Proceedings of CSA, 2009, p. 1-

Analyzing storage media of digital camera

Digital photography has become popular in recent years. Photographs have become common tools for people to record every tiny parts of their daily life. By analyzing the storage media of a digital camera, crime investigators may extract a lot of useful information to reconstruct the events. In this work, we will discuss a few approaches in analyzing these kinds of storage media of digital cameras. A hypothetical crime case will be used as case study for demonstration of concepts. © 2009 IEEE.published_or_final_versionThe 2009 International Workshop on Forensics for Future Generation Communication Environments (F2GC-09) in conjunction with CSA 2009, Jeju Island, Korea, 10-12 December 2009. In Proceedings of CSA, 2009, p. 1-

Attenuation of Hind-limb Ischemia in Mice with Endothelial-like Cells Derived from Different Sources of Human Stem Cells

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Improvement of Myocardial Function Following Catheter-Based Renal Denervation in Heart Failure

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Recent Advances in Animal and Human Pluripotent Stem Cell Modeling of Cardiac Laminopathy

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Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA

Friedreich’s ataxia (FRDA), a recessive neurodegenerative disorder commonly associated with hypertrophic cardiomyopathy, is caused by silencing of the frataxin (FXN) gene encoding the mitochondrial protein involved in iron-sulfur cluster biosynthesis. We aimed to utilize our previously established FRDA human induced pluripotent stem cell (hiPSC) derived cardiomyocytes model as a platform to assess the efficacy of treatment with either the antioxidant coenzyme Q10 analog, idebenone (IDE) or the iron chelator, deferiprone (DFP), which are both under clinical trial. In fact, DFP was able to more significantly suppress synthesis of reactive oxygen species (ROS) than IDE at the dosages of 10 nM and 25 μM respectively which agreed with the reduced rate of intracellular accumulation of iron by DFP treatment from 25 to 50 µM. With regard to cardiac electrical-contraction (EC) coupling function, decay velocity of calcium handling kinetics in FRDA-hiPSC-cardiomyocytes was significantly improved by DFP treatment but not by IDE. Further mechanistic studies revealed DFP also modulated iron induced mitochondrial stress as reflected by mitochondria network disorganization and decline in level of respiratory chain protein. In addition, iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by the attenuated transferrin receptor (TSFR) suppression thereby reducing further iron uptake.published_or_final_versio

Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells.

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