24 research outputs found
Vasoactive properties of cannabinoid agonists in isolated bovine ophthalmic arteries: role of nitric oxide
Functional characterization of vasorelaxant responses to cannabinoid agonists in bovine ophthalmic arteries
Effects of phorbol ester on carbachol-induced contraction in bovine ciliary muscle: possible involvement of protein kinase C
L-type calcium channels modulate the regression of left ventricular hypertrophy after ace-inhibition in genetic hypertension
Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitization
Involvement of FP and CB receptors in the contractile effects by prostamides on the human ciliary muscle
Alteration of endothelium dependent vascular relaxation by aging and effect of a growth hormone-releasing peptide
Apraclonidine hydrochloride: pharmacology and clinical use
Apraclonidine hydrochloride is a potent and relatively selective alpha2-adrenergic receptor agonist. The alpha2-adrenoceptor is widely expressed in the eye, located in the anterior segment for example in the cornea, trabecular meshwork, iris, ciliary body epithelium and ciliary muscle and in the posterior segment in structures such as the retina, retinal pigment epithelium and choroid. Apraclonidine is useful in the diagnosis of Horner Syndrome. It is also used to prevent intraocular pressure spikes after anterior segment laser surgery or following cataract surgery. It can also be used as a temporary adjunctive drug in patients with open-angle glaucoma on maximal therapy before laser trabeculoplasty or surgery, and as a treatment for ptosis secondary to injections of botulinum toxin on the upper third of the face