634 research outputs found

    Effects of Isometric Handgrip Training in Patients With Peripheral Artery Disease: A Randomized Controlled Trial

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    BackgroundMeta‐analyses have shown that isometric handgrip training (IHT) can reduce brachial systolic and diastolic blood pressure (BP) by >6/4 mm Hg, respectively. However, whether IHT promotes these effects among patients with peripheral artery disease, who exhibit severe impairment in cardiovascular function, is currently unknown. This study aimed to evaluate the effects of IHT on the cardiovascular function of patients with peripheral artery disease. Methods and ResultsA randomized controlled trial with peripheral artery disease patients assigned to either the IHT or control group was conducted. The IHT group performed 3 sessions per week, for 8 weeks, of unilateral handgrip exercises, consisting of 4 sets of isometric contractions for 2 minutes at 30% of maximum voluntary contraction and a 4‐minute interval between sets. The control group received a compression ball in order to minimize the placebo effects, representing sham training. The primary outcome was brachial BP. The secondary outcomes were central BP, arterial stiffness parameters, cardiac autonomic modulation, and vascular function. The IHT program reduced diastolic BP (75 [10] mm Hg preintervention versus 72 [11] mm Hg postintervention), with no change in the control group (74 [11] mm Hg preintervention versus 74 [11] mm Hg postintervention), with this between‐group difference being significant (P=0.04). Flow‐mediated dilation improved in the IHT group (6.0% [5.7] preintervention versus 9.7% [5.5] postintervention), with no change in the control group (7.6% [5.5] preintervention versus 7.4% [5.1] postintervention), with this between‐group difference being significant (P=0.04). There was no change in other measured variables over the intervention period. ConclusionsIHT reduced brachial diastolic BP and improved local vascular function in patients with peripheral artery disease

    Tecnologia de sementes de espécies florestais nativas da Amazônia.

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    Laboratório de sementes florestais; Introdução; Estudos de germinação; Tamanho e forma de sementes; Fitopatologia de sementes.bitstream/item/49443/1/fd090001.pdf1 folder

    Distinct fos-expressing neuronal ensembles in the ventromedial prefrontal cortex mediate food reward and extinction memories

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    In operant learning, initial reward-associated memories are thought to be distinct from subsequent extinction-associated memories. Memories formed during operant learning are thought to be stored in “neuronal ensembles.” Thus, we hypothesize that different neuronal ensembles encode reward- and extinction-associated memories. Here, we examined prefrontal cortex neuronal ensembles involved in the recall of reward and extinction memories of food self-administration.Wefirst trained rats to lever press for palatable food pellets for 7 d (1 h/d) and then exposed them to 0, 2, or 7 daily extinction sessions in which lever presses were not reinforced. Twenty-four hours after the last training or extinction session, we exposed the rats to either a short 15 min extinction test session or left them in their homecage (a control condition). We found maximal Fos (a neuronal activity marker) immunoreactivity in the ventral medial prefrontal cortex of rats that previously received 2 extinction sessions, suggesting that neuronal ensembles in this area encode extinction memories. We then used the Daun02 inactivation procedure to selectively disrupt ventral medial prefrontal cortex neuronal ensembles that were activated during the 15 min extinction session following 0 (no extinction) or 2 prior extinction sessions to determine the effects of inactivating the putative food reward and extinction ensembles, respectively, on subsequent nonreinforced food seeking 2 d later. Inactivation of the food reward ensembles decreased food seeking, whereas inactivation of the extinction ensembles increased food seeking. Our results indicate that distinct neuronal ensembles encoding operant reward and extinction memories intermingle within the same cortical area

    Efeito de bioestimulantes sobre as características de produção de videiras Thompson Seedless.

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    Com o objetivo de avaliar o efeito preliminar de bioestimulantes comerciais sobre as características de produção da videira, foi conduzido um experimento de campo com a cultivar Thompson Seedless, enxertada sobre o porta-enxerto ?Harmony?. Os tratamentos foram constituídos de quatro bioestimulantes, aplicados em três doses, correspondendo a um fatorial 4x3, disposto em blocos casualizados com quatro repetições. No período de pleno florescimento foram coletadas amostras de folhas completas para determinação dos teores totais de nutrientes. Por ocasião da colheita foram avaliadas a produção e algumas características biométricas dos cachos. Houve efeito dos bioestimulantes sobre as concentrações foliares de nitrogênio e potássio e das doses de bioestimulantes sobre os teores de cálcio no período de florescimento. Nenhum dos fatores em estudo, bioestimulantes ou doses, proporcionou aumento da produção, nem sobre a maior parte das características biométricas dos cachos. Esta avaliação preliminar não permitiu observar nenhum efeito robusto dos bioestimulantes sobre as características de produção da videira
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