Meaning is about mattering: evaluating coherence, purpose, and existential mattering as precursors of meaning in life judgments

When people judge their lives as meaningful, what is this judgment about? Drawing on recent tripartite theoretical accounts of meaning in life (MIL), we tested the separate contributions of coherence (or comprehension), purpose, and existential mattering (or significance) as potential precursors of people’s self-reported evaluations of MIL. In Study 1 (N = 314 social media users), we developed brief acquiescence-free measures of these constructs, confirming that sense of coherence, purpose, mattering, and MIL judgments were distinct from each other and from related constructs (sense of control, belonging, self-esteem, self-competence, mood). In Study 2 (N = 168 students) and Study 3 (N = 442 Prolific Academic respondents; preregistered), we collected longitudinal data to test temporal relationships between coherence, purpose, mattering, and MIL judgments over a 1-month time lag. In both studies, sense of mattering consistently emerged as a significant precursor of MIL judgments, whereas sense of purpose and coherence did not. We conclude that researchers and practitioners should pay more attention to the relatively neglected dimension of existential mattering, beyond their more common emphases on coherence or purpose as bases of meaningfulness

Androgenic alopecia; the risk–benefit ratio of Finasteride

Finasteride is currently approved and largely used as a therapeutic option for androgenetic alopecia. Apparently a safe drug and effective at the onset of its application, several concerns have since appeared over the years regarding the frequency and magnitude of finasteride adverse effects, which in some cases appear irreversible even after drug termination. This paper discusses the use of finasteride for androgenic alopecia from two distinct perspectives. On the one hand, androgenic alopecia is a condition that especially affects a person’s self-image and esteem, aspects that are subjectively-constructed and thus relative and changeable. On the other hand, this condition involves a multifactorial etiology, with androgens being only partly responsible. Because androgens have important and unique physiological roles within the body, any procedure that results in androgenic suppression should be advised with caution. Furthermore, adverse effects induced by finasteride are neither fully documented nor easily treated. Finally, as alternative therapeutic approaches (such as topical finasteride) become available, the oral administration of finasteride for androgenic alopecia should, in our opinion, be reevaluated. Due to such concerns, a detailed and informed discussion should take place with patients considering therapy with finasteride for androgenic alopecia

Synthesis and Characterization of Three-Coordinate Ni(III)-Imide Complexes

A new family of low-coordinate nickel imides supported by 1,2-bis(di-tert-butylphosphino)ethane was synthesized. Oxidation of nickel(II) complexes led to the formation of both aryl- and alkyl-substituted nickel(III)-imides, and examples of both types have been isolated and fully characterized. The aryl substituent that proved most useful in stabilizing the Ni(III)-imide moiety was the bulky 2,6-dimesitylphenyl. The two Ni(III)-imide compounds showed different variable-temperature magnetic properties but analogous EPR spectra at low temperatures. To account for this discrepancy, a low-spin/high-spin equilibrium was proposed to take place for the alkyl-substituted Ni(III)-imide complex. This proposal was supported by DFT calculations. DFT calculations also indicated that the unpaired electron is mostly localized on the imide nitrogen for the Ni(III) complexes. The results of reactions carried out in the presence of hydrogen donors supported the findings from DFT calculations that the adamantyl substituent was a significantly more reactive hydrogen-atom abstractor. Interestingly, the steric properties of the 2,6-dimesitylphenyl substituent are important not only in protecting the Ni═N core but also in favoring one rotamer of the resulting Ni(III)-imide, by locking the phenyl ring in a perpendicular orientation with respect to the NiPP plane

Statistical properties of an ensemble of vortices interacting with a turbulent field

We develop an analytical formalism to determine the statistical properties of a system consisting of an ensemble of vortices with random position in plane interacting with a turbulent field. We calculate the generating functional by path-integral methods. The function space is the statistical ensemble composed of two parts, the first one representing the vortices influenced by the turbulence and the second one the turbulent field scattered by the randomly placed vortices.Comment: Third version; Important corrections in the normalization for the gas of vortices, et

Hexachlorinated Boron(III) Subphthalocyanine as Acceptor for Organic Photovoltaics: A Brief Overview

A boron(III) complex of peripherally hexachlorinated subphthalocyanine, Cl6SubPc is a very promising small-molecule acceptor for application in organic photovoltaics. In this chapter the recent experimental results in the field are compared, and a critical review is given of the published works on the solar cells with the planar or bulk heterojunction architectures. The thin film properties of Cl6SubPc are also considered. The approaches to the further modification of the molecular structure of boron(III) subphthalocyanine-type compounds for the enhancement of their photoelectrical properties are discussed

Therapeutic Considerations Related to Finasteride Administration in Male Androgenic Alopecia and Benign Prostatic Hyperplasia

Finasteride has been used extensively until now as a relative efficient therapeutic option for male androgenic alopecia and benign prostatic hyperplasia. Unfortunately, over time several concerns appeared regarding the frequency and magnitude of adverse effects, which in some cases have been even irreversible. Herein we review the recent literature on this topic, trying to clarify the current safety profile of Finasteride for these two therapeutic indications. We concluded that Finasteride could be retained as a therapeutic approach for male androgenic alopecia, based on two important reasons. First, a synergistic action between a partial inhibitor of 5α-reductase (Finasteride) and another compound (like Minoxidil) are preferable to a complete suppression of 5α-reductase (see Dutasteride), in order to preserve the important physiological roles of dihydrotestosterone. Second, Finasteride side effects can currently be addressed in part prior to the onset of the therapy, by using information about the patient such as hand preference and sexual orientation to predict the risk of adverse effects

An extended hybrid magnetohydrodynamics gyrokinetic model for numerical simulation of shear Alfv\'en waves in burning plasmas

Adopting the theoretical framework for the generalized fishbonelike dispersion relation, an extended hybrid magnetohydrodynamics gyrokinetic simulation model has been derived analytically by taking into account both thermal ion compressibility and diamagnetic effects in addition to energetic particle kinetic behaviors. The extended model has been used for implementing an eXtended version of Hybrid Magnetohydrodynamics Gyrokinetic Code (XHMGC) to study thermal ion kinetic effects on Alfv\'enic modes driven by energetic particles, such as kinetic beta induced Alfv\'en eigenmodes in tokamak fusion plasmas

The postfinasteride syndrome; an overview

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.” Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse effects after treatment cessation. Moreover, we argue that finasteride adverse effects occurring during finasteride administration should be delineated from postfinasteride side effects (encountered after treatment cessation), suggesting the need to be addressed separately within a therapeutic perspective. Until a tailored therapeutic approach of postfinasteride syndrome becomes available, we have noted that hand preference and sexual orientation seem to be useful as possible predicting factors for finasteride side effects and postfinasteride syndrome. Finally, even though finasteride administration is considered relatively safe, literature data urges prudence. Specifically, recent studies report that some subjects receiving finasteride develop severe depressive episodes including suicidal thoughts, in part due to persistent sexual side effects