1,824 research outputs found
Ultramicronized N-Palmitoylethanolamine Supplementation for Long-Lasting, Low-Dosed Morphine Antinociception
Get PDFEffects of Hypericum perforatum extract on oxaliplatin-induced neurotoxicity: in vitro evaluations
Get PDFPalmitoylethanolamide is a disease-modifying agent in peripheral neuropathy : pain relief and neuroprotection share a PPAR-alpha-mediated mechanism
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Effect of Vitis vinifera hydroalcoholic extract against oxaliplatin neurotoxicity: in vitro and in vivo evidence
Get PDFPain relieving and protective effects of Astragalus hydroalcoholic extract in rat arthritis models
Get PDFBacopa monnieri as augmentation therapy in the treatment of anhedonia, preclinical and clinical evaluation
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Efficacy of isothiocyanate-based compounds on different forms of persistent pain.
Get PDFCurrent pharmacotherapy for persistent pain related to neuropathy or articular diseases is unsatisfactory, due to the large number of unresponsive patients and side effects. Isothiocyanates (ITCs) are a class of natural or synthetic compounds characterized by the general formula R-NCS. ITCs show antihyperalgesic effects in models of central and peripheral nervous tissue injury and anti-inflammatory properties. The pharmacodynamics are strictly related to the release of the gasotransmitter hydrogen sulfide (H2S) from their moiety. In particular, phenyl ITC (PITC) and 3-carboxyphenyl ITC (3C-PITC) exhibit interesting slow H2S-release properties suitable for treating painful pathology. The aim of the present work was to evaluate the efficacy of PITC and 3C-PITC against mechanical hyperalgesia and spontaneous pain induced by nerve injury and osteoarthritis
Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.
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