Glial Cyst in the Thalamus with Intracystic Hemorrhage -Case Report- (視床の嚢胞内出血を伴う神経膠嚢胞 症例報告）

雑誌掲載版頭痛,失神発作を訴えた19歳女.CT上,視床に嚢胞内出血を伴う嚢胞性腫瘤病変を認め,出血により急性水頭症を起こしていた.亜全摘した.組織学的には著明なヘモジデリン沈着物を伴う軽度の神経膠症が認められた.嚢胞壁の内面は上皮性内張を欠いていた.神経膠嚢胞と診断された.術後2ヵ月のMRIは左視床床に遺残嚢胞を示した.12ヵ月後,無症候で神経学的に無傷でMRIは嚢胞の再成長を示さなかった

Measurements of the partial pressure of CO2 in the air and surface sea water on board the icebreaker SHIRASE

With a newly developed automatic measurement system, the partial pressure of CO_2 in the surface sea water and lower troposphere were continuously monitored on board the icebreaker SHIRASE between Japan and Antarctica from November 1987 to March 1992 as a part of the Japanese Antarctic Research Expedition (JARE). The atmospheric CO_2 concentration was high in the midnorthern hemisphere, decreased rapidly southward to a minimum in the midsouthern hemisphere, and increased slightly in the Antarctic region. Water mass differences in the western North Pacific and eastern Indian Ocean can be seen in diagrams which consists of CO_2 partial pressure in surface sea water (pCO_2) and sea surface temperature (SST). These water masses are bordered at the boundaries of major oceanic currents : the southern border of the Kuroshio Countercurrent (28°N), the southern border of the Subtropical Countercurrent (20°N), the southern border of the North Equatorial Current (6°N), the southern border of the Celebes Sea, and the Lombok Strait. The relations between pCO_2 variations and hydrographic conditions such as the effect of coastal water and upwelling are subject to discussion in this report. Meridional distributions of pCO_2 and SST south of 35°S obtained in the southward cruise on 110°E in December, the northward cruise on 150°E in March, and the cruise between Syowa Station (69°00′S, 39°35′E) and Cape Town in January 1989 clearly show steep changes at the Subtropical Convergence, Subantarctic Front, and Polar Front. Even if pCO_2 within each water mass distributed between the fronts varies to some extent, each water mass can be distinguished from the other masses by the differences of average pCO_2 and SST. Longitudinal distributions of pCO_2 and SST measured in the westward track from 110°E to 20°E along 59°S to 61°S and the eastward track from 40°E to 150°E along 61°S to 65°S are scattered between 320μatm and 360μatm. However it is clearly evident that the pCO_2 dips by 50μatm between 80°E and 110°E. Anticyclonic eddies which are already found in the region could drive coastal water, which has less pCO_2 because of high productivity, northward. The partial pressure difference between air and surface sea water (△pCO_2) and CO_2 flux across the air-sea boundary was calculated to estimate the CO_2 source/sink strength of the ocean along the track. The region between the Subantarctic Front and the Polar Front, and the region south of the Polar Front, which are regarded as a data void region, are very weak CO_2 sources as well as very weak CO_2 sinks and weak CO_2 sinks by 0 to -5mol・m^・yr^, respectively

カイニン酸誘発皮質てんかんモデルを用いた外科的治療(Multiple Subpial Transection)の基礎的研究(1)

雑誌掲載版1)カイニン酸を猫の一側大脳皮質(感覚運動野)に局所注入し,部分発作重積状態を作成した後,同部にmultiple subpial transectionを施行すると発作は消失した。2)麻酔下の実験のため,発作を誘発できるカイニン酸の量は一定しなかった。3)カイニン酸20μg以下では,急性実験終了し,麻酔から覚醒した後も痙攣発作は生じなかった。しかし,25μg以上の注入では,焦点部が広く強力になるため,実験の翌日に部分てんかい重積状態となり,MSTは,無効であっ

カイニン酸誘発皮質てんかんモデルを用いたMultiple Subpial Transectionの基礎的研究(2)

雑誌掲載版MSTにより大脳皮質にカイニン酸を注入することに生じる2次性全般化は,抑制された。しかし,部分発作は,抑制されなかった。1ヵ月後の病理組織では,MSTに沿ってgliosis,血腫,ヘモジデリンの沈着を認めた。長期にわたっては,最も発作が誘発されやすい部位の一つである感覚野皮質に瘢痕を形成すること及び,新たなてんかん焦点が形成される可能性を示し

視床下部hamartomaに合併したWest syndromeの1例

雑誌掲載

てんかんと興奮性アミノ酸

雑誌掲載

ラット橋網様体カイニン酸注入による全般性強直発作モデル

雑誌掲載版全般強直発作(GT)の動物モデルをラットの橋網様体(PRF)にカイニン酸(KA)注入により作成した.KA注入後,平均50.9分でPRFと両側感覚運動皮質に高振巾棘波を認めた.次に局所グルコース消費(LCGU)を14C-2-deoxyglucoseを用い急性発作時に測定し,両側中脳,橋の網様体などでLCGUが増加することを認めた.またKA注入側で外,内側膝状体等に著明な増加を認めた.これらの所見からPRFは強直発作の原発及び続発全般化に重要であり,発作波の伝播はPRFから内側前頭束を通り,視床下部,前頭基底部に入り,更に大脳皮質に達すると間代発作を生じるものと推測され

両側側頭葉てんかん焦点モデル

雑誌掲載版今回,作製したモデルの特徴は,KA注入後の慢性期に右,左,或いは両側の扁桃核より自発性の辺縁系発作が起こることであ