288 research outputs found
Can economic sanctions lead to fraud? Nations might turn to virtual currencies if slapped with restrictions
REPEAT USERS OF CRISIS RESOLUTION AND HOME TREATMENT TEAM
CRHT services have reduced admissions to psychiatric hospitals. Some patients use CRHT services repeatedly. We reviewed the
first 30 patients who were repeat users of the CRHT services, Luton, between 1 August 2010 and 31 July 2011. The repeat users were
a small group of patients needing disproportionately large amounts of resources from the CRHT service. The factors associated with
repeat use of CRHT were past psychiatric admission and the diagnoses of emotionally unstable personality disorder, self-harm
behaviour and substance misuse. Identifying the factors leading to repeat CRHT use could lead to providing a more tailored service
and reduce repeat use of these services. It appears that repeat CRHT service use might be the result of the interaction of a wide
range of factors relating to underlying disorder, substance misuse, self harm behaviour, employment status and social support. It is
also important to note that many of the patients are liable to relapse as they go through stressful life situations, despite adequate
medication and psychosocial intervention. It can be difficult to identify all the factors that contribute to a pattern of repeat
presentation to CRHT services. However, identification of such factors might help clinicians to offer more targeted services and
might also assist commissioners in focusing resources effectively. They might need more intensive community-based programs to
identify and treat the relapses. The CRHT teams should include all the appropriate professional disciplines required to provide
community care for these challenging service users
Logarithmic Corrections to Twisted Indices from the Quantum Entropy Function
We compute logarithmic corrections to the twisted index in
four-dimensional and string theories using the
framework of the Quantum Entropy Function. We find that these vanish, matching
perfectly with the large--charge expansion of the corresponding microscopic
expressions.Comment: v2 : 22 pages, presentation significantly improved, published in JHE
The future of raising finance - a new opportunity to commit fraud: a review of initial coin offering (ICOs) scams
3-Aryl-1-phenyl-1H-pyrazole derivatives as new multitarget directed ligands for the treatment of Alzheimer's disease, with acetylcholinesterase and monoamine oxidase inhibitory properties
A series of 3-aryl-1-phenyl-1H-pyrazole derivatives was synthesized in good yield and assayed in vitro as inhibitors of the mice acetylcholinesterase (AChE) and two goat liver monoamine oxidase (MAO) isoforms, MAO-A and MAO-B. Most of the compounds demonstrated a good AChE and selective MAO-B inhibitory activities in the nanomolar or low micromolar range. N-((3-(4-chlorophenyl)-1-phenyl-1H-pyrazole-4-yl) methylene) benzenamine (3e, pIC50 = 4.2) and N-((4-fluorophenyl)-1-phenyl-1H-pyrazole-4-yl) methylene) methanamine
(3f, pIC50 = 3.47) were the most potent AChE
and highly selective MAO-B inhibitors respectively. Structure activity relationships showed that chloro derivatives were more effective AChE inhibitors as compared to fluoro derivatives while reverse trend was observed in MAO-B inhibitory activity. With the aid of modeling studies, potential binding orientations as well as interactions of the compounds in the AChE and MAO-B active sites were examined
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