Creative solutions as derivatives of selective multiple testing

Algorithm of creative solutions as derivatives of selective multiple testing: A. Initial selection of multiple testing methods A1. Selection of independent and dependent variability; Calculating the of mean, standard error of mean, standard deviation, 95% confidence interval for mean, median, minimum, maximum, range, quartiles; Determination of the variabilities distribution - parametric or nonparametric by single-factor the Kolmogorov-Smirnov test; Shapiro-Wilk W test and graphical methods: frequency distribution histograms stem & leaf plots; scatter plots; box & whisker plots; normal probability plots: PP and QQ plots; graphs with error bars (Graphs: Error Bar). A2. ANOVA (Analysis of Variance) test is used for parametric variabilities distribution. If deviations are homogeneous by Levene test would used the method of multiple comparison groups by Tukey HSD, Scheffe, Bonferroni, and in the cases without homogeneity we must use the criteria Tamhane's T2, Games-Howell; Kruskal-Wallis test, nonparametric equivalent of the ANOVA, is used for nonparametric variabilities distribution; A3. The selection of variabilities, as criteria for making decisions, with P = .05 or less, and / or minimal false discovery rate, q-value (Gyorffy B, Gyorffy A, Tulassay Z:. The problem of multiple testing and its solutions for genom-wide studies. Orv Hetil, 2005;146(12):559-563) Determination of the sensitivity and specificity of these variabilities. B. Secondary screening the variabilities for multiple test methods. B1. These numerical dependent variabilities with P = .05 or less, and / or minimal false discovery rate, with high sensitivity and specificity by diagnostic capabilities must use for formation of new variabilities as descendants of 2, 3, 4 .. n numerical dependent variabilities as the derivatives of various mathematical transformations as Cantor, Sierpinski, von Koch sets, etc., anti-fractal sets; Moebius strip like aggregates, oxymoron combinations (Kulishov S.K., Iakovenko O.M.: Fractal and antifractal oxymorons, Moebius strip like transformations of biomedical data as basis for exploratory subgroup analysis. Book of abstract of International Conference on Trends and Perspective in Linear Statistical Inference; LinStat, 2014, Linkoping, Sweden, August 24-28, 2014; 2014, 58); and others mathematical transformations derivatives. C. Check the newly formed variabilities similar to step A to estimate the effectiveness of such changes. D. Comparison of multiple testing of more informative primary and secondary variabilities by accuracy, sensitivity and specificity of diagnostic possibilities. E. If it's necessary, the search of new selection principles of variabilities for multiple testing must be continued

Fractals as triggers exploratory statistical analysis of clinical pharmacological data

Proposed and tested an algorithm of using principles of Cantor, von Koch sets for exploratory fractals clinical pharmacological data analysis. The algorithm is based on the grouping data, formation of categorical variabilities in the form of subgroups as iteration process as for receiving Cantor, von Koch sets. It boils down to: selection of informative numerical dependent variabilities; transformation these informative numerical dependent variabilities to new categorical variabilities; formation categorical variabilities in the form of subgroups as a result of an iterative process as for Cantor, von Koch sets; statistical analysis of the data; determination of the distribution of variabilities; transformations that may be normalize from non-normal data; ANOVA - analysis of variance parametric data or nonparametric equivalent of ANOVA - Kruskal-Wallis testing; formulation of the conclusion. Our algorithm of using Cantor, von Koch sets principles for Exploratory Fractals Data Analysis of clinical pharmacological data will help maximize insight, uncover underlying structure, extract important variables, develop models and determine optimal factor settings

Moebius Strip Like Pathology: Mechanisms, Diagnosis, Treatment Correction

Proposed and tested an algorithm for diagnosis of Moebius strip like pathology, as prerequisite for treatment correction. The algorithm is reduced to initialization of study objects as a Moebius strip, in particular symptoms, syndromes, diseases, multimorbid states; clarification of investigation objects as non-orientable two-dimensional surface; cutting a Moebius strip like clinical data, variability to form two disjoint Moebius strips; clarification of chirality Moebius strip turn; the determination of Moebius strip like constituents as the object of research and their 3D representation; clarification of Moebius strips turn chiralities of constituents; the adoption of diagnostic and therapeutic solutions based on geometry of the pathogenetic and sanogenetic mechanisms. Thus, our algorithm may be basis for making diagnosis and treatment decisio

Psychological and stress characteristics of patients with coronary heart disease as prerequisite for individual psychotherapy

Background: Stress and ischemia play a leading role in the occurrence and progression of coronary heart disease (CHD). The aim of the study was to determine psychological characteristics and stress sensitivity in the patients with CHD as prerequisite to improving of diagnosis and treatment. Objects and methods: The study involved 22 patients with CHD. Psychological research was conducted by the method of “constructive human pattern of geometric figures”, stressful sensitivity - by the psychoemotional Stroop test. Statistical analysis included parametric and nonparametric correlation analysis. Results: The predominance of triangles in figures of psycho-graphics test in patients with coronary heart disease leads to higher levels of pulse arterial pressure, heart rate in compare with diastolic arterial pressure during the psycho-emotional Stroop test. The predominance of the squares is characterized by an increasing ratio of diastolic arterial pressure to heart rate. The prevalence of triangles or squares in the drawings of psycho-graphics test leads to prolongation of reading time. Conclusion: The investigation results of CHD patients by psycho-graphic, psycho-emotional tests may be a prerequisite for inclusion different methods of meditation, psychotherapy to reduce the sensitivity to stress, myocardial ischemi

Формування професійної особистості лікаря через застосування в навчанні принципів внутрішньої медицини, інформатики, нелінійної математики

Створення європейського простору вищої освіти сприяє вдосконаленню навчального процесу підготовки майбутніх лікарів із метою підвищення рівня їхньої професійної спрямованості та конкурентоспроможності для забезпечення ефективнішого розвитку суспільства

Differentiatial Diagnosis of Dermatoglyphic Peculiarities in the Patients with Coronary Heart Disease and Chronic Kidney Disease

Prediction genetically predisposed people to heart and kidney failure is an actual problem. Dermatoglyphics can be one of the basic research in this area. The purpose of the study was to determine the features of dermatoglyphics in the patients with coronary heart disease and chronic kidney disease with chronic renal failure for making differential diagnosis. The object of the study were 25 patients (45-77 y.o.) with chronic coronary heart disease and 20 patients (42,65 ± 0,71 y.o.) with chronic kidney disease. Investigation and treatment of the patients was carried out in accordance with the standards. Dermatoglyphic study was conducted by the method of fingerprinting surfaces phalanges, using paint. Statistical methods of evaluation findings included parametric and non-parametric statistical methods. Results. The prevalence of ulnar loops on fingers of right hand was typical feature for patients with chronic kidney disease and radial loops on fingers of right hand for patients with coronary heart disease. The predominance of racemates from ulnar loops scallops on the left and right hands was a distinctive sign for the patients with chronic kidney disease in compare to the patients with coronary heart disease. Dissymmetry of scallops in the patients with coronary heart disease was characterized by predominance of radial loops on fingers of right hand in compare with left; predominance of ulnar loops on fingers of left hand in compare with right. Thus, quantity of different types of scallops, their dissymmetry or racemates on fingers of the left and right hands are basis for differential diagnosis between patients with coronary heart disease and chronic kidney disease

Інтерактивне навчання внутрішньої медицини як технологія включення студентів в управління навчальним процесом

Стаття присвячена ролі інтерактивних технологій у сучасній освіті та медичній зокрема. Автори доводять, що завдяки використанню інтерактивних методів технологій на кафедрі внутрішньої медицини не лише змінюється роль викладача, а й відбувається включення студентів в управління навчальним процесом

System and atisystem comparison as method and learning environment for creative clinical thinking training

Системне та антисистемне співставлення як метод та середовище для навчання творчому клінічному мисленню запропоновано та впроваджено для вирішення діагностичних і лікувальних проблем. Алгоритм базується на теоріях вирішення винахідницьких завдань, написання хайку, оксюморонів. Він зводиться до пошуку системно-антисистемних комплексів симптомів, синдромів, формулювання діагнозу, який базується на фрактальних механізмах синдромів; призначення індивідуального лікування та вторинної профілактики. Використання навчального середовища (зразки системно-антисистемного співставлення в медицині, літературі, малюнках), електронних методів навчання, в тому числі віртуальних класів, покращує якість навчання клінічному творчому мисленню ; System and anti-system comparison as method and medium for creative clinical thinking training were proposed and implemented for solving diagnostic and treatment problems. The algorithm is based on theories of solving inventive problems, writing haiku, an oxymoron. It boils down to searching of system-antisystem symptoms’ complexes, syndromes, formulating a diagnosis supported by fractal syndromes’ mechanisms; the prescription of individual approaches to treatment and secondary prevention. Using the learning environment (samples of system and antisystem comparison in medicine, literature and drawings), electronic methods, including virtual classes, improves the quality of clinical creative thinking training