16 research outputs found
Algorithm of morphological diagnostics of small cell lung cancer on bronchial biopsy
Results of cytologicai, histological and immunohistochemical analyses of bronchial biopsies of 95 patients with small cell lung cancer have been provided in this paper. In 85.3% of the cases small cell lung cancer within optic level has been verified by complex cytologicai and histological diagnosis. In the rest of 14.7% of the cases it has been revealed the necessity of using additional analysis methods to detect a version of small cell lung cancer. In 24 cases immunohistochemical analysis has been made, in 10 of them - to confirm morphological diagnosis of small cell lung cancer, in 14 of them - to detect a version of small cell lung tumour by using different antibodies sets depending on differentially diagnostic series. Immunohistochemical analysis has shown that 20 tumours have immunophenotype of small cell lung cancer, trustworthy lung adenocarcinoma, diffuse large cell Π-cell lymphoma and mammary gland carcinoma. It has been worked out an algorithm of complex histological, cytologicai and immunohistochemical methods of diagnostics. Using it allows to improve diagnostics of small cell lung cancer on data of bronchial biopsies.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΠΈΠΎΠΏΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ² 95 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
. Π 85,3% ΡΠ»ΡΡΠ°Π΅Π² Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π½Π° ΡΠ²Π΅ΡΠΎΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΡΠΎΠ²Π½Π΅ ΠΏΡΠΈ ΠΏΠΎΠΌΠΎΡΠΈ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Π² ΠΎΡΡΠ°Π²ΡΠΈΡ
ΡΡ 14,7% ΡΠ»ΡΡΠ°Π΅Π² Π²ΡΡΠ²Π»Π΅Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π»Π΅Π³ΠΊΠΈΡ
. Π 24 ΡΠ»ΡΡΠ°ΡΡ
ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π² 10 ΡΠ»ΡΡΠ°ΡΡ
- Π΄Π»Ρ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, Π² 14 β Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π½Π°Π±ΠΎΡΠΎΠ² Π°Π½ΡΠΈΡΠ΅Π» Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎ ΡΡΠ΄Π°. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ 20 ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΠΈΠΌΠ΅ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅Π½ΠΎΡΠΈΠΏ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, ΠΎΡΡΠ°Π²ΡΠΈΠ΅ΡΡ ΡΠ΅ΡΡΡΠ΅ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ β ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅Π½ΠΎΡΠΈΠΏ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΏΠ»ΠΎΡΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, Π½ΠΈΠ·ΠΊΠΎΠ΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΡΠΎΠ»ΠΈΠ΄Π½ΠΎΠ³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΡ, ΠΊΡΡΠΏΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π»ΠΈΠΌΡΠΎΠΌΡ ΠΈ ΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ. Π‘ΡΠΎΡΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½ Π°Π»Π³ΠΎΡΠΈΡΠΌ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ³ΠΎ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΎΠΏΡΠΈΠΌΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ Π±ΠΈΠΎΠΏΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ²
Morphological diagnostics off small cell lung cancer
Now lung cancer (LC) has remained the most widespread malignant tumour and the most frequent cause of death of people with this disease (this disease) in the world. It's accepted to divide all histological types of LC into small cell and non-small cell variants that is caused by essentially different ways of treatment. Small cell lung cancer (SCLC) is a malignant epithelial tumour of neuroendocrinal nature consisting of small round or oval cells with scant cytoplasm, finely granular nuclear chromatin and absent nucleoli. Necrosis is typically extensive and mitotic activity is high. Combined SCLC contains a component of any nonΒsmall cell lung cancer in a tumour structure. Immunohistochemical research of SCLC shows positive reaction on synaptophysin, C056 and chromogranin. The main method to receive material for morphological research at SCLC is bronchoscopy combined with forceps biopsy of affected bronchus. Small size of bronchial biopsy material and its crash during intake make morphological diagnostics difficult. Exact morphological diagnostics of SCLC is essentially important because it defines tactics of treatment which consists mainly in chemotherapy.Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (Π Π) ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½Π½ΠΎΠΉ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ ΠΈ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎΠΉ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΡΠΌΠ΅ΡΡΠΈ Π±ΠΎΠ»ΡΠ½ΡΡ
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ Π½ΠΎΠ²ΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡΠΌΠΈ Π² ΠΌΠΈΡΠ΅. ΠΡΠΈΠ½ΡΡΠΎ ΠΏΠΎΠ΄ΡΠ°Π·Π΄Π΅Π»ΡΡΡ Π²ΡΠ΅ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠΈΠΏΡ Π Π Π½Π° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΈ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½ΡΡ, ΡΡΠΎ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΈΠ°Π»ΡΠ½ΠΎ ΡΠ°Π·Π½ΡΠΌΠΈ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π°ΠΌΠΈ ΠΊ Π»Π΅ΡΠ΅Π½ΠΈΡ. ΠΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (ΠΠ Π) ΡΠ²Π»ΡΠ΅ΡΡΡ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ, ΡΠΎΡΡΠΎΡΡΠ΅ΠΉ ΠΈΠ· ΠΌΠ΅Π»ΠΊΠΈΡ
ΠΎΠΊΡΡΠ³Π»ΡΡ
ΠΈΠ»ΠΈ ΠΎΠ²Π°Π»ΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠΎ ΡΠΊΡΠ΄Π½ΠΎΠΉ ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠΎΠΉ, Π½Π΅ΠΆΠ½ΠΎ-Π³ΡΠ°Π½ΡΠ»ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌ ΡΠ΄Π΅ΡΠ½ΡΠΌ Ρ
ΡΠΎΠΌΠ°ΡΠΈΠ½ΠΎΠΌ ΠΈ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ΠΌ ΡΠ΄ΡΡΡΠ΅ΠΊ. Π₯Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎ ΠΎΠ±ΠΈΠ»ΠΈΠ΅ Π½Π΅ΠΊΡΠΎΠ·ΠΎΠ² ΠΈ Π²ΡΡΠΎΠΊΠ°Ρ ΠΌΠΈΡΠΎΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ. ΠΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΠ Π ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ Π² ΡΡΡΡΠΊΡΡΡΠ΅ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ Π»ΡΠ±ΠΎΠ³ΠΎ Π½Π΅ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°. ΠΡΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΠΠ Π Π΄Π°Π΅Ρ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠ΅Π°ΠΊΡΠΈΡ Π½Π° ΡΠΈΠ½Π°ΠΏΡΠΎΡΠΈΠ·ΠΈΠ½, CD56 ΠΈ Ρ
ΡΠΎΠΌΠΎΠ³ΡΠ°Π½ΠΈΠ½. ΠΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π΄Π»Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΠ Π ΡΠ²Π»ΡΠ΅ΡΡΡ Π±ΡΠΎΠ½Ρ
ΠΎΡΠΊΠΎΠΏΠΈΡ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ ΡΠΎ ΡΠΈΠΏΡΠΎΠ²ΠΎΠΉ Π±ΠΈΠΎΠΏΡΠΈΠ΅ΠΉ ΠΏΠΎΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ³ΠΎ Π±ΡΠΎΠ½Ρ
Π°. ΠΠ°ΡΡΡΠ΄Π½ΡΠ΅Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΠΌΠ°Π»ΡΠΉ ΡΠ°Π·ΠΌΠ΅Ρ ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΠΎΠ³ΠΎ ΠΊΡΡΠΎΡΠΊΠ° ΡΠΊΠ°Π½ΠΈ ΠΈ Π΅Π³ΠΎ ΡΠ°Π·Π΄Π°Π²Π»ΠΈΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΈ Π·Π°Π±ΠΎΡΠ΅. Π’ΠΎΡΠ½Π°Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ° ΠΠ Π ΠΊΡΠ°ΠΉΠ½Π΅ Π²Π°ΠΆΠ½Π°, ΡΠ°ΠΊ ΠΊΠ°ΠΊ ΠΎΠ½Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΡΠ°ΠΊΡΠΈΠΊΡ Π»Π΅ΡΠ΅Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΠ°Ρ Π·Π°ΠΊΠ»ΡΡΠ°Π΅ΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π² Ρ
ΠΈΠΌΠΈΠΎΡΠ΅ΡΠ°ΠΏΠΈΠΈ
Pathomorphology of small cell lung cancer on bronchial biopsy (histological and cytological comparisons)
In the paper there have been shown the results of histological and cytological studies of bronchial biopsies of patients with small cell lung tumors, compared data of histological and cytological studies and defined the structure of small cell lung cancer (variants of cyto-histological structure). In 85.3% of the cases it was managed to verify precisely the small-cell lung cancer, and in the remaining 14.7% of the cases it was revealed the need for immunohistochemical studies to identify the version of small-cell bronchial cancer. In 82.7% of the cases in the structure of small-cell lung cancer there was revealed the prevalence of oat cell variant including oat cell variant proper, oat cell variant with parts of intermediate cellular texture, oat cell variant of lymphocyte-like texture and oat cell variant with parts of both intermediate cellular and lymphocyte-like texture. In 9.9% of the cases small cell lung cancer had intermediate cellular texture, and in 7.4% of the cases variant of small cell lung cancer could not have been identified because of the evident crush phenomenon caused by the fragility of the tumor tissue and its crushing when obtaining biopsy material. In 60.0% of the cases the cytological findings coincided with the histological ones and the tumor structure in the smear test matched histological structure of SCLC. Integrated use of histological and cytological methods makes it possible to improve the diagnostics of small cell lung cancer on bronchial biopsy findings.Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±ΠΈΠΎΠΏΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ² Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΌΠ΅Π»ΠΊΠΎΒΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΌΠΈ ΠΎΠΏΡΡ
ΠΎΠ»ΡΠΌΠΈ Π»Π΅Π³ΠΊΠΈΡ
, ΡΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π° ΡΡΡΡΠΊΡΡΡΠ° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (Π²Π°ΡΠΈΠ°Π½ΡΡ ΡΠΈΡΠΎ-Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΡ). Π 85,3% ΡΠ»ΡΡΠ°Π΅Π² ΡΠ΄Π°Π»ΠΎΡΡ ΡΠΎΡΠ½ΠΎ Π²Π΅ΡΠΈΡΠΈΡΠΈΡΠΎΠ²Π°ΡΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, Π² ΠΎΡΡΠ°Π²ΡΠΈΡ
ΡΡ 14,7% ΡΠ»ΡΡΠ°Π΅Π² Π²ΡΡΠ²Π»Π΅Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ². Π ΡΡΡΡΠΊΡΡΡΠ΅ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π² 82,7% ΡΠ»ΡΡΠ°Π΅Π² Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ ΠΎΠ²ΡΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π²Π°ΡΠΈΠ°Π½ΡΠ°, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎ ΠΎΠ²ΡΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ, ΠΎΠ²ΡΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ Ρ ΡΡΠ°ΡΡΠΊΠ°ΠΌΠΈ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΡ, ΠΎΠ²ΡΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ Ρ ΡΡΠ°ΡΡΠΊΠ°ΠΌΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΡ ΠΈ ΠΎΠ²ΡΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ Π²Π°ΡΠΈΠ°Π½Ρ Ρ ΡΡΠ°ΡΡΠΊΠ°ΠΌΠΈ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠΏΠΎΠ΄ΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΡΡΠΎΠ΅Π½ΠΈΡ. Π 9,9% ΡΠ»ΡΡΠ°Π΅Π² ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΡΠ°ΠΊ ΠΈΠΌΠ΅Π» ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ΅ ΡΡΡΠΎΠ΅Π½ΠΈΠ΅, Π° Π² 7,4% ΡΠ»ΡΡΠ°Π΅Π² Π²Π°ΡΠΈΠ°Π½Ρ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ Π½Π΅ ΡΠ΄Π°Π»ΠΎΡΡ ΠΈΠ·-Π·Π° Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΡ
ΡΠ²Π»Π΅Π½ΠΈΠΉ ΠΊΡΠ°Ρ-ΡΠ΅Π½ΠΎΠΌΠ΅Π½Π°, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Ρ
ΡΡΠΏΠΊΠΎΡΡΡΡ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΈ Π΅Ρ ΡΠ°Π·Π΄Π°Π²Π»ΠΈΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΠΈ Π±ΠΈΠΎΠΏΡΠ°ΡΠ°. Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π΄Π°Π½Π½ΡΠ΅ Π² 60,0% ΡΠ»ΡΡΠ°Π΅Π² ΡΠΎΠ²ΠΏΠ°Π΄Π°Π»ΠΈ Ρ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ ΡΡΡΡΠΊΡΡΡΡ Π² ΠΌΠ°Π·ΠΊΠ°Ρ
ΠΏΠΎΠ²ΡΠΎΡΡΠ»ΠΈ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΡΡΠΎΠ΅Π½ΠΈΠ΅ ΠΠ Π. ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎΠ΅ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΠ»ΡΡΡΠΈΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ Π±ΠΈΠΎΠΏΡΠΈΠΉ Π±ΡΠΎΠ½Ρ
ΠΎΠ²
Morphometry of cells of small-cell lung cancer in histological and cytological samples
A morphometric comparative study of the sizes of small cell lung cancer cells in histological specimens and cytological smears obtained from 103 patients was carried out. It was shown that the area of tumor cells in cytological samples was significantly 4 times more than in histological sections. The cause of the identified phenomena is the differences in the features of fixation and preparation of the preparations, as well as the possibility of deforming the tumor cells.ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΌΠΎΡΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ°Π·ΠΌΠ΅ΡΠΎΠ² ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠ΅Π»ΠΊΠΎΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π² Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°Ρ
ΠΈ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°Π·ΠΊΠ°Ρ
, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΎΡ 103 Π±ΠΎΠ»ΡΠ½ΡΡ
. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΠ»ΠΎΡΠ°Π΄Ρ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ Π² ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΠ±ΡΠ°Π·ΡΠ°Ρ
Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π² 4 ΡΠ°Π·Π° Π±ΠΎΠ»ΡΡΠ΅, ΡΠ΅ΠΌ Π² Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π·Π°Ρ
. ΠΡΠΈΡΠΈΠ½Π° Π²ΡΡΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ²Π»Π΅Π½ΠΈΡ β ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² ΠΌΠ΅ΡΠΎΠ΄Π°Ρ
ΡΠΈΠΊΡΠ°ΡΠΈΠΈ ΠΈ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π΄Π΅ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ
Methods of liquid based cytology and cell block in morphological diagnostics of lung tumors
The article contains a detailed description of methods of liquid-based cytology and cell block, based on literature data and personal experience. The capabilitiesof these methods have been assessed in order to improve the quality of morphological diagnosis of lung cancer by testing the material of lung resectates. The lung resectates have been comprehensively investigated histologically and cytologically with the use of standard techniques as well as methods of liquid-based cytology and cell block; in some of the cases immunohistochemical and immunocytochemical studies have been done additionally. The results of morphological studies of lung resectates, done with the use of methods of liquid-based cytology and cell block, have demonstrated the data that is identical to standard methods that has provided their high diagnostic value. Immunohistochemical and immunocytochemical studies of the materials of paraffin blocks and cell block have demonstrated identical responses on prevalence and intensity. Thus, cell block compared with liquid-based cytology has a number of advantages, namely the ability of doing a study of any cytological material along with production of high-quality drugs that are closer to histological ones due to the possibility of access to the internal cell structures that allows them to doimmunocytochemical study, which results are considered to be the most important thing to define further tactics of patient management, especially in the absence of the possibility of obtaining histological material.Π ΡΡΠ°ΡΡΠ΅ ΠΈΠ·Π»ΠΎΠΆΠ΅Π½Π° ΠΏΠΎΠ΄ΡΠΎΠ±Π½Π°Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΡΠΈΡΠΎΠ±Π»ΠΎΠΊΠ°, ΠΎΡΠ½ΠΎΠ²Π°Π½Π½Π°Ρ Π½Π° Π΄Π°Π½Π½ΡΡ
Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΈ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ°. ΠΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ Π΄Π°Π½Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ Π΄Π»Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΡΡΠ΅ΠΌ ΠΈΡ
Π°ΠΏΡΠΎΠ±Π°ΡΠΈΠΈ Π½Π° ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΡΠ΅Π·Π΅ΠΊΡΠ°ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
. Π Π΅Π·Π΅ΠΊΡΠ°ΡΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΈ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΡΠΈΡΠΎΠ±Π»ΠΎΠΊΠ°, Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²ΡΠΏΠΎΠ»Π½Π΅Π½Ρ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΈΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π·Π΅ΠΊΡΠ°ΡΠΎΠ² Π»Π΅Π³ΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌΠΈ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΡΠΈΡΠΎΠ±Π»ΠΎΠΊΠ° ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅, ΠΈΠ΄Π΅Π½ΡΠΈΡΠ½ΡΠ΅ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ°ΠΌ, Π΄ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΠΈΠ΅ ΠΈΡ
Π²ΡΡΠΎΠΊΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠ΅Π½Π½ΠΎΡΡΡ. Π¦ΠΈΡΠΎΠ±Π»ΠΎΠΊ, ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ, ΠΈΠΌΠ΅Π΅Ρ ΡΡΠ΄ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ², Π·Π°ΠΊΠ»ΡΡΠ°ΡΡΠΈΡ
ΡΡ Π² Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π»ΡΠ±ΠΎΠ³ΠΎ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Ρ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ Π²ΡΡΠΎΠΊΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ², Π±ΠΎΠ»Π΅Π΅ ΠΏΡΠΈΠ±Π»ΠΈΠΆΠ΅Π½Π½ΡΡ
ΠΊ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π΄ΠΎΡΡΡΠΏΡ ΠΊ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΠΌ ΡΡΡΡΠΊΡΡΡΠ°ΠΌ ΠΊΠ»Π΅ΡΠΎΠΊ, ΡΡΠΎ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΠΏΠΎΠ»Π½ΠΎΡΠ΅Π½Π½ΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΈΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΊΠΎΡΠΎΡΡΡ
Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π²Π°ΠΆΠ½Ρ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅ΠΉ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π²Π΅Π΄Π΅Π½ΠΈΡ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΎΡΡΡΡΡΡΠ²ΠΈΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°
Nosological structure of respiratory organs pathology according to operational material and biopsies.
To learn the nosological structure of respiratory system pathology, the analyses of the results of pathological research of biopsy and resection material from 1584 patients in 2018. As a result of this research there was found the significant predominance of biopsy material over the resection material that could be explained by the diagnosis tasks and surgical tactics depending on the kind of case and its phase. In the structure of respiratory system pathology it was detected the significant predominance of lungs cancer, the correlation of histological forms of which depends on the kind of morphological material, and in this case to specify the diagnosis it is necessary to make immunohistochemistry.C ΡΠ΅Π»ΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π½ΠΎΠ·ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΠ² Π΄ΡΡ
Π°Π½ΠΈΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΠΈΠΎΠΏΡΠΈΠΉΠ½ΠΎΠ³ΠΎ ΠΈ ΡΠ΅Π·Π΅ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° 1584 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π·Π° 2018Π³ΠΎΠ΄. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ Π±ΠΈΠΎΠΏΡΠΈΠΉΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° Π½Π°Π΄ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ, ΡΡΠΎ ΠΌΠΎΠΆΠ½ΠΎ ΠΎΠ±ΡΡΡΠ½ΠΈΡΡ Π·Π°Π΄Π°ΡΠ°ΠΌΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΡΠ°ΠΊΡΠΈΠΊΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΈΠ΄Π° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ Π΅Π³ΠΎ ΡΡΠ°Π΄ΠΈΠΈ. Π ΡΡΡΡΠΊΡΡΡΠ΅ Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ ΠΎΡΠ³Π°Π½ΠΎΠ² Π΄ΡΡ
Π°Π½ΠΈΡ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΎΡΠ»ΠΈΡΠ°Π΅ΡΡΡ Π² Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ Π²ΠΈΠ΄Π° ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°, ΠΏΡΠΈ ΡΡΠΎΠΌ Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² Π΄Π»Ρ ΡΡΠΎΡΠ½Π΅Π½ΠΈΡ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° ΡΡΠ΅Π±ΡΠ΅ΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈΠΌΠΌΡΠ½ΠΎΠ³ΠΈΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ
New classification of lung cancer WHO, 2015: comments and recommendations for implementation
The article presents the materials describing the main changes in the new version of the classification of lung tumors by WHO. The main authors of the Classification isolated as a review article 16 points on which changes in comparison with the 2004 revision. We believe that the most significant changes related to the new multidisciplinary approach, reflected in the classification of lung adenocarcinoma, 2011, the allocation of a separate section diagnosis of lung cancer in small samples, the reclassification of neuroendocrine tumors with their association into a single group, and while maintaining the classic versions NET of lungs. After the publication of the WHO classification it becomes recommendatory document, which is the multidisciplinary classification of lung adenocarcinoma, 2011, and binding, and the implementation of practical activities of pulmonary pathologists, oncomorphologists and other doctors.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠ΅ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² Π½ΠΎΠ²ΠΎΠΉ ΡΠ΅Π΄Π°ΠΊΡΠΈΠΈ ΠΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π»Π΅Π³ΠΊΠΈΡ
ΠΠΠ. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ Π°Π²ΡΠΎΡΡ ΠΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π²ΡΠ΄Π΅Π»ΡΡΡ Π² ΠΎΠ±Π·ΠΎΡΠ½ΠΎΠΉ ΡΡΠ°ΡΡΠ΅ 16 ΠΏΡΠ½ΠΊΡΠΎΠ², ΠΏΠΎ ΠΊΠΎΡΠΎΡΡΠΌ Π²Π½Π΅ΡΠ΅Π½Ρ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΠΏΠ΅ΡΠ΅ΡΠΌΠΎΡΡΠΎΠΌ 2004 Π³ΠΎΠ΄Π°. ΠΡ ΠΏΠΎΠ»Π°Π³Π°Π΅ΠΌ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ²ΡΠ·Π°Π½Ρ Ρ Π½ΠΎΠ²ΡΠΌ ΠΌΡΠ»ΡΡΠΈ-Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΡΠΌ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠΌ, ΠΎΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌ Π² ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ 2011 Π³ΠΎΠ΄Π°, Π²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠΈ Π² ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠΉ ΡΠ°Π·Π΄Π΅Π» Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ ΠΏΠΎ ΠΌΠ°Π»ΡΠΌ ΠΎΠ±ΡΠ°Π·ΡΠ°ΠΌ, ΡΠ΅ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π΅ΠΉΡΠΎΡΠ½Π΄ΠΎΠΊΡΠΈΠ½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Ρ ΠΎΠ±ΡΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠ΅ΠΌ ΠΈΡ
Π² Π΅Π΄ΠΈΠ½ΡΡ Π³ΡΡΠΏΠΏΡ ΠΈ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈ ΡΡΠΎΠΌ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π²Π°ΡΠΈΠ°Π½ΡΠΎΠ² ΠΠ0 Π»Π΅Π³ΠΊΠΈΡ
. ΠΠΎΡΠ»Π΅ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΠΠ ΠΎΠ½Π° ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ Π½Π΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠ΅Π»ΡΠ½ΡΠΌ Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠΌ, ΠΊΠ°ΠΊΠΎΠ²ΡΠΌ ΡΠ²Π»ΡΠ»Π°ΡΡ ΠΌΡΠ»ΡΡΠΈΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½Π°Ρ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ 2011 Π³ΠΎΠ΄Π°, Π° ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΠΊ ΠΈΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΠΈ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ Π² ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΡΡ Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡ Π»Π΅Π³ΠΎΡΠ½ΡΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΎΠ², ΠΎΠ½ΠΊΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΎΠ² ΠΈ Π²ΡΠ°ΡΠ΅ΠΉ Π΄ΡΡΠ³ΠΈΡ
ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΡΡΠ΅ΠΉ
Morphological diagnosis of intravenous addicts autopsy dead patients with HIV infection
The pathological examination materials 89 autopsies TSPAO Sverdlovsk regional traffic for 2015. Along with the standard procedures used microscopy studies of drugs in polarized light. The frequency of detection of morphological signs of chronic intravenous drug-addiction - CIA (angiogenic talcosis) in the formulations was 39.3% (35 cases). Target organs for angiogenic talcosis are the lungs, liver and spleen. The features of the location and the size of the anisotropic crystals in the tissues of these organs. Method for detection of anisotropic crystals of talc in the tissues and organs of deceased patients with HIV infection should be recommended for the diagnosis of morphological objectification CIA in these cases.ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² 89 Π°ΡΡΠΎΠΏΡΠΈΠΉ Π¦ΠΠΠ Π‘Π²Π΅ΡΠ΄Π»ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΠ’Π Π·Π° 2015 Π³ΠΎΠ΄. ΠΠ°ΡΡΠ΄Ρ ΡΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈΠΊΠ°ΠΌΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π² ΠΏΠΎΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΌ ΡΠ²Π΅ΡΠ΅. Π§Π°ΡΡΠΎΡΠ° ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΡΠ°Π²Π΅Π½ΠΎΠ·Π½ΠΎΠΉ Π½Π°ΡΠΊΠΎΠΌΠ°Π½ΠΈΠΈ (Π₯ΠΠ) Π² Π²ΠΈΠ΄Π΅ Π°Π½Π³ΠΈΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ°Π»ΡΠΊΠΎΠ·Π° Π² ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°Ρ
ΡΠΎΡΡΠ°Π²ΠΈΠ»Π° 39,3% (35 ΡΠ»ΡΡΠ°Π΅Π²). ΠΡΠ³Π°Π½Π°ΠΌΠΈ-ΠΌΠΈΡΠ΅Π½ΡΠΌΠΈ Π΄Π»Ρ Π°Π½Π³ΠΈΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ°Π»ΡΠΊΠΎΠ·Π° ΡΠ²Π»ΡΡΡΡΡ Π»Π΅Π³ΠΊΠΈΠ΅, ΠΏΠ΅ΡΠ΅Π½Ρ ΠΈ ΡΠ΅Π»Π΅Π·Π΅Π½ΠΊΠ°. ΠΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΠ°Π·ΠΌΠ΅ΡΡ Π°Π½ΠΈΠ·ΠΎΡΡΠΎΠΏΠ½ΡΡ
ΠΊΡΠΈΡΡΠ°Π»Π»ΠΎΠ² Π² ΡΠΊΠ°Π½ΡΡ
ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
ΠΎΡΠ³Π°Π½ΠΎΠ². ΠΠ΅ΡΠΎΠ΄ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π½ΠΈΠ·ΠΎΡΡΠΎΠΏΠ½ΡΡ
ΠΊΡΠΈΡΡΠ°Π»Π»ΠΎΠ² ΡΠ°Π»ΡΠΊΠ° Π² ΡΠΊΠ°Π½ΡΡ
ΠΈ ΠΎΡΠ³Π°Π½Π°Ρ
ΡΠΌΠ΅ΡΡΠΈΡ
Π±ΠΎΠ»ΡΠ½ΡΡ
ΠΠΠ§-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄ΠΎΠ²Π°ΡΡ Π΄Π»Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ΅ΠΊΡΠΈΠ²ΠΈΠ·Π°ΡΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π° Π₯ΠΠ Π² ΡΡΠΈΡ
ΡΠ»ΡΡΠ°ΡΡ
Evolution of the ideas about bronchioloalveolar carcinoma and a new classification of lung adenocarcinoma
The article presents materials on the history of learning problems bronchioloalveolar cancer, selected periods of his research and the evolution of the concept of a bronchioloalveolar cancer. The authors have more than 30 years of experience studying of this problem. The results of these studies and the literature data are given in the comparative aspect of the four histological classification of lung tumors of WHO (1967,1981,1999,2004), and a new multidisciplinary classification of lung adenocarcinoma (2011). The last article understands in detail. It is shown that the basis of the new classification is the revision of the threat of ΠΠΠ‘ until complete failure from the use of this term.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΏΠΎ ΠΈΡΡΠΎΡΠΈΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ Π±ΡΠΎΠ½Ρ
ΠΈΠΎΠ»ΠΎΠ°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°, Π²ΡΠ΄Π΅Π»Π΅Π½Ρ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ Π΅Π³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΈ ΠΏΠΎΠΊΠ°Π·Π°Π½Π° ΡΠ²ΠΎΠ»ΡΡΠΈΡ ΡΠ°ΠΌΠΎΠ³ΠΎ ΠΏΠΎΠ½ΡΡΠΈΡ Π±ΡΠΎΠ½Ρ
ΠΈΠΎΠ»ΠΎΠ°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°. ΠΠ²ΡΠΎΡΡ ΡΠ°ΡΠΏΠΎΠ»Π°Π³Π°ΡΡ Π±ΠΎΠ»Π΅Π΅ ΡΠ΅ΠΌ 30-Π»Π΅ΡΠ½ΠΈΠΌ ΠΎΠΏΡΡΠΎΠΌ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΈ Π΄Π°Π½Π½ΡΠ΅ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π² Π°ΡΠΏΠ΅ΠΊΡΠ΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΡΡΠ΅Ρ
Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π»Π΅Π³ΠΊΠΈΡ
ΠΠΠ (1967,1981,1999,2004 Π³Π³.) ΠΈ Π½ΠΎΠ²ΠΎΠΉ ΠΌΠ΅ΠΆΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ (2011Π³.). ΠΠΎΡΠ»Π΅Π΄Π½ΡΡ ΡΡΠ°ΡΡΡ ΡΠ°Π·Π±ΠΈΡΠ°Π΅ΡΡΡ ΠΏΠΎΠ΄ΡΠΎΠ±Π½ΠΎ. ΠΡΠΈ Π·ΡΠΎΠΌ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π² ΠΎΡΠ½ΠΎΠ²Π΅ Π½ΠΎΠ²ΠΎΠΉ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ Π»Π΅ΠΆΠΈΡ ΡΠ΅Π²ΠΈΠ·ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΠΠ Π²ΠΏΠ»ΠΎΡΡ Π΄ΠΎ ΠΏΠΎΠ»Π½ΠΎΠ³ΠΎ ΠΎΡΠΊΠ°Π·Π° ΠΎΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΌΠΈΠ½Π°
Cell block method in morphologic diagnostics of tumorous pleura lesions studied on the material of pleural fluid
In the article there have been estimated the resources of cell block method by having conducted an immunocytochemical research for further morphologic diagnostics of tumorous pleura lesions studied on the material of pleural fluid. During the research pleural fluid of patients with unilateral tumorous pleura lesions was studied with cell block method. Cell blocks were studied with immunocytochemical method and there were verified metastases of lung adenocarcinoma in pleura and mesothelioma. The results of the research have proved diagnostic significance of cell block method that improves quality of morphologic diagnostics of tumours of various localizations and provides conducting a valuable immunocytochemical research without using methods of βexplosiveβ fixation that is especially valued when it is impossible to get histological material.Π ΡΡΠ°ΡΡΠ΅ ΠΎΡΠ΅Π½Π΅Π½Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠΈΡΠΎΠ±Π»ΠΎΠΊΠ° Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ΠΌ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΈΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ ΠΏΠ»Π΅Π²ΡΡ Π½Π° ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ. Π Ρ
ΠΎΠ΄Π΅ ΡΠ°Π±ΠΎΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠΈΡΠΎΠ±Π»ΠΎΠΊΠ° ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° ΠΏΠ»Π΅Π²ΡΠ°Π»ΡΠ½Π°Ρ ΠΆΠΈΠ΄ΠΊΠΎΡΡΡ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΠΎΠ΄Π½ΠΎΡΡΠΎΡΠΎΠ½Π½ΠΈΠΌ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΠ»Π΅Π²ΡΡ. ΠΠ° ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π΅ ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π±Π»ΠΎΠΊΠΎΠ² Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΈΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Ρ ΠΌΠ΅ΡΠ°ΡΡΠ°Π·Ρ Π°Π΄Π΅Π½ΠΎΠΊΠ°ΡΡΠΈΠ½ΠΎΠΌΡ Π»Π΅Π³ΠΊΠΎΠ³ΠΎ Π² ΠΏΠ»Π΅Π²ΡΠ΅ ΠΈ ΠΌΠ΅Π·ΠΎΡΠ΅Π»ΠΈΠΎΠΌΠ°. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π΄ΠΎΠΊΠ°Π·Π°Π½Π° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠΈΡΠΎΠ±Π»ΠΎΠΊΠ°, ΠΏΠΎΠ²ΡΡΠ°ΡΡΠ΅Π³ΠΎ ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π»ΠΎΠΊΠ°Π»ΠΈΠ·Π°ΡΠΈΠΉ Ρ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΏΠΎΠ»Π½ΠΎΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΎΡΠΈΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Π½Π΅ ΠΏΡΠΈΠ±Π΅Π³Π°Ρ ΠΊ ΠΌΠ΅ΡΠΎΠ΄Π°ΠΌ Β«Π²Π·ΡΡΠ²Π½ΠΎΠΉΒ» ΡΠΈΠΊΡΠ°ΡΠΈΠΈ, ΡΡΠΎ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎ ΡΠ΅Π½Π½ΠΎ ΠΏΡΠΈ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π³ΠΈΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π°