Risk-adjusted therapy for pediatric non-T cell ALL improves outcomes for standard risk patients: results of JACLS ALL-02

This study was a second multicenter trial on childhood ALL by the Japan Childhood Leukemia Study Group (JACLS) to improve outcomes in non-T ALL. Between April 2002 and March 2008, 1138 children with non-T ALL were enrolled in the JACLS ALL-02 trial. Patients were stratified into three groups using age, white blood cell count, unfavorable genetic abnormalities, and treatment response: standard risk (SR), high risk (HR), and extremely high risk (ER). Prophylactic cranial radiation therapy (PCRT) was abolished except for CNS leukemia. Four-year event-free survival (4yr-EFS) and 4-year overall survival (4yr-OS) rates for all patients were 85.4% ± 1.1% and 91.2% ± 0.9%, respectively. Risk-adjusted therapy resulted in 4yr-EFS rates of 90.4% ± 1.4% for SR, 84.9% ± 1.6% for HR, and 66.5% ± 4.0% for ER. Based on NCI risk classification, 4yr-EFS rates were 88.2% in NCI-SR and 76.4% in NCI-HR patients, respectively. Compared to previous trial ALL-97, 4yr-EFS of NCI-SR patients was significantly improved (88.2% vs 81.2%, log rank p = 0.0004). The 4-year cumulative incidence of isolated (0.9%) and total (1.5%) CNS relapse were significantly lower than those reported previously. In conclusion, improved EFS in NCI-SR patients and abolish of PCRT was achieved in ALL-02

IGF-1 Induction by Acylated Steryl β-Glucosides Found in a Pre-Germinated Brown Rice Diet Reduces Oxidative Stress in Streptozotocin-Induced Diabetes

BACKGROUND: The pathology of diabetic neuropathy involves oxidative stress on pancreatic β-cells, and is related to decreased levels of Insulin-like growth factor 1 (IGF-1). Acylated steryl β-glucoside (PR-ASG) found in pre-germiated brown rice is a bioactive substance exhibiting properties that enhance activity of homocysteine-thiolactonase (HTase), reducing oxidative stress in diabetic neuropathy. The biological importance of PR-ASG in pancreatic β-cells remains unknown. Here we examined the effects of PR-ASG on IGF-1 and glucose metabolism in β-cells exposed to oxidative stress. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, a pre-germinated brown rice (PR)-diet was tested in streptozotocin (STZ)-induced diabetic rats. Compared with diabetic rats fed control diets, the PR-diet fed rats showed an improvement of serum metabolic and neurophysiological parameters. In addition, IGF-1 levels were found to be increased in the serum, liver, and pancreas of diabetic rats fed the PR-diet. The increased IGF-1 level in the pancreas led us to hypothesize that PR-ASG is protective for islet β-cells against the extensive injury of advanced or severe diabetes. Thus we examined PR-ASG to determine whether it showed anti-apoptotic, pro-proliferative effects on the insulin-secreting β-cells line, INS-1; and additionally, whether PR-ASG stimulated IGF-1 autocrine secretion/IGF-1-dependent glucose metabolism. We have demonstrated for the first time that PR-ASG increases IGF-1 production and secretion from pancreatic β-cells. CONCLUSION/SIGNIFICANCE: These findings suggest that PR-ASG may affect pancreatic β-cells through the activation of an IGF-1-dependent mechanism in the diabetic condition. Thus, intake of pre-germinated brown rice may have a beneficial effect in the treatment of diabetes, in particular diabetic neuropathy

学生生活チェックカタログを用いた学生生活の実態調査 : 介護福祉学科学生の結果

本研究は、学生の学習や日常生活の支援の方向性を検討するために、九州大学健康科学センターの峰松らが作成した「学生生活チェックカタログ(ver.3)」を使用し、介護福祉学科学生の学生生活の実態を調査した。その結果、以下のことが明らかになった。1.QOSL合計得点と満足度得点は正の相関があり、学年が進むにつれ、得点が増加する傾向がみられた。2.QOSL各領域の平均値では、「社会的関係」「未来的展望」において、2年生が1年生より有意に高かった。(p<.05) 3.1年生に対する修学相談・進路に関する情報提供等の必要性が示唆された。This research investigated the actual condition of the student life of the Care and Welfare students. Catalog of Quality of Student Life (version 3) which was invented and developed by Professor Minematsu from the Health Science Center at Kyushu University was used. The following points were revealed. There was a positive correlation between the QOSL score in total and the satisfaction score. As the students get older, the score was also increased. Average QOSL score in items such as "Social Relationship" or "Future Prospect" was higher among the 2nd year students compared to that of the 1st year students. It was revealed that information about the course and the job opportunities after graduation should be given fully to the 1st year students

学生生活チェックカタログを用いた学生生活の実態調査 : 看護学科学生の結果

本研究は、学生生活の実態を把握する目的で、九州大学健康科学センターの峰松らが作成した「学生生活チェックカタログ(ver.3)」を使用して調査した。その結果、以下のことが明らかになった。1.QOSL合計得点と満足度得点は、他学校より本学は高く、QOSLや満足度の高い学生生活を送っている。2.QOSLの合計得点と満足度得点は正の相関があり、学生が満足感のある学生生活を送れるよう支援することが大切である。3.QOSL各領域の得点と具体的内容には学年差があり、各学年の特徴をふまえ支援することが大切である。4.情報収集メディアを活用できる環境、人間関係を緊密にする場、学生が具体的な行動に移せる支援の必要性が示唆された。This research investigated the actual condition of the student life of the Care and Welfare students. Catalog of Quality of Student Life (version 3) which was invented and developed by Associate Professor Minematsu from the Health Science Center at Kyushu University was used. The following points were revealed. 1. The result showed that the QOSL score in total and the satisfaction score were higher compared to other schools and it can be generally said that the students are enjoying the school life. 2. There was a positive correlation between the QOSL score in total and the satisfaction score and it is necessary to support the students to be able to lead satisfied and enjoyable school life. 3. It was revealed that there was a difference in QOSL scores and its contents according to the students\u27 age. It is necessary to grasp the characteritscis of students of different grades and give enough support. 4. It was also discussed that to give students support and an environment where they can utilize the information they have collected as well as fostering the healthy human relationship

Self-actualization of junior high school students (2) : An analysis of the relationships among self-actualization of child, self-actualization of parents, and mutual cognition of parental rearing behavior

The purpose of the present study was to identify the relationships among self-actualization of junior high school students, self-actualization of their parents, and mutual cognition about parental rearing behavior. Self-actualization Scale and Parental Behavior Inventory (EICA) were administered to 83 junior high school students (44 males and 39 females) and their parents. EICA consists of four factors : Emotional support, Identification, Control, Autonomy. Results of factor analysis showed that self-actualization of junior high school students was composed of seven factors. Multiple regression analysis revealed that self-actualization of fathers had a greater influence on self-actualization of their children than that of mothers, and that Emotional support of mothers promoted self-actualization of their children while Control of mothers inhibited it. It was suggested that fathers play a significant role in self-actualization and mothers play an important role in mental support for their children