Nano encapsulation of Drug-loaded Lipid by Temperature induced Phase Transition

Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a drug delivery system, the release pattern of model drugs was observed

Nano encapsulation of Drug-loaded Lipid by Temperature induced Phase Transition

Pluronic nanoparticles (NPs) were prepared by means of a temperature-induced phase transition in the mixture composed of Pluronic F-68 and liquid Tween 80/soybean oil containing model drugs such as orlistat, caffeine, and ibuprofen sodium salt. Liquid soybean oil/Tween 80 was used as a solubilizer for model drugs, and Pluronic F-68 was the polymer that stabilizes liquid soybean oil/Tween 80 containing model drugs. Field-emission scanning electron microscopy and particle size analyzer were used to observe the morphology and size distribution of the prepared NPs. X-ray diffractometer was used to understand relationship between the crystalline state of the model drug and its solubility in the aqueous media. To observe the feasibility of Pluronic NPs as a drug delivery system, the release pattern of model drugs was observed

Parametrization of nonlinear and chaotic oscillations in driven beam-plasma diodes

Nonlinear phenomena in a driven plasma diode are studied using a fluid code and the particle-in-cell simulation code XPDPI. When a uniform electron beam is injected to a bounded diode filled with uniform ion background, the beam is destabilized by the Pierce instability and a perturbation grows to exhibit nonlinear oscillations including chaos. Two standard routes to chaos, period doubling and quasiperiodicity, are observed. Mode lockings of various winding numbers are observed in an ac driven system. A new diagnostic quantity is used to parametrize various nonlinear oscillations.open10

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans

10.1186/s13195-015-0137-yAlzheimer's Research and Therapy715

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)

10.1371/journal.pone.0144758PLoS ONE1012e014475

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease

10.1371/journal.pone.0084349PLoS ONE91e8434

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid ?-Protein-Induced Synapse Loss in Alzheimer's Disease

10.1016/j.celrep.2020.107839Cell Reports311310783

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

10.1371/journal.pone.0111553PLoS ONE910e11155