Population Dynamics and Ecology of White-tailed Deer in Illinois W-87-R-17, Final Report July 1, 1994 - June 30, 1995

Final Report July 1, 1994 - June 30, 1995 issued June 1, 1995Report issued on: June 1, 1995INHS Technical Report prepared for Department of Natural Resource

Cooperative Furbearer Research Illinois Raccoon Investigations Final Report W-104-R-6

Final Report W-104-R-6Report issued on: June 30, 1995INHS Technical Report prepared for unspecified recipien

Illinois Forest Game Investigations W-87-R-16, Annual Job Progress Report 1 July 1993 - 30 June 1994

Study no. 1: Population dynamics and ecology of white-tailed deer in Illinois.Report issued on: 15 August 1994INHS Technical Report prepared for Department of Natural Resource

Illinois Forest Game Investigations W-87-R-13, Annual Job Progress Report

W-87-R-13; Annual Job Progress Report July 1, 1990 - June 30, 1991 issued August 31, 1991; Sub-project No VII: Illinois Deer Investigations; Study No. 1: Population Dynamics of the Illinois Deer Herd.Report issued on: August 31, 199

Illinois Forest Game Investigations W-87-R-15, Annual Job Progress Report 1 July 1992 - 30 June 1993

Study no. 1: Population dynamics and ecology of white-tailed deer in Illinois.Report issued on: 31 August 1993INHS Technical Report prepared for Department of Natural Resource

Population Dynamics of the Illinois Deer Herd: Illinois Forest Game Investigations W-87-R-12, 13, 14, Final Report 1 July 1989 through 30 June 1992

Project Title: Cooperative Forest Wildlife Research; Subproject No.: VII, Title: Illinois Deer Investigations; Study No. 1 Title: Population dynamics of the Illinois deer herdReport issued on: August 31, 1992INHS Technical Report prepared for unspecified recipien

Cooperative Furbearer Research Illinois Raccoon Investigations Annual Job Progress Report 1 July 1993 through 30 June 1994

Federal Aid in Wildlife Restoration W-104-R-5Ope

Cooperative Furbearer Research Illinois Raccoon Investigations Annual Job Progress Report 1 July 1990 through 30 June 1991

Federal Aid in Wildlife Restoration Project W-104-R-2unpublishednot peer reviewedOpe

Expression quantitative trait locus fine mapping of the 17q12–21 asthma locus in African American children: a genetic association and gene expression study

Background: African ancestry is associated with a higher prevalence and greater severity of asthma than European ancestries, yet genetic studies of the most common locus associated with childhood-onset asthma, 17q12–21, in African Americans have been inconclusive. The aim of this study was to leverage both the phenotyping of the Children's Respiratory and Environmental Workgroup (CREW) birth cohort consortium, and the reduced linkage disequilibrium in African Americans, to fine map the 17q12–21 locus. Methods: We first did a genetic association study and meta-analysis using 17q12–21 tag single-nucleotide polymorphisms (SNPs) for childhood-onset asthma in 1613 European American and 870 African American children from the CREW consortium. Nine tag SNPs were selected based on linkage disequilibrium patterns at 17q12–21 and their association with asthma, considering the effect allele under an additive model (0, 1, or 2 effect alleles). Results were meta-analysed with publicly available summary data from the EVE consortium (on 4303 European American and 3034 African American individuals) for seven of the nine SNPs of interest. Subsequently, we tested for expression quantitative trait loci (eQTLs) among the SNPs associated with childhood-onset asthma and the expression of 17q12–21 genes in resting peripheral blood mononuclear cells (PBMCs) from 85 African American CREW children and in upper airway epithelial cells from 246 African American CREW children; and in lower airway epithelial cells from 44 European American and 72 African American adults from a case-control study of asthma genetic risk in Chicago (IL, USA). Findings: 17q12–21 SNPs were broadly associated with asthma in European Americans. Only two SNPs (rs2305480 in gasdermin-B [GSDMB] and rs8076131 in ORMDL sphingolipid biosynthesis regulator 3 [ORMDL3]) were associated with asthma in African Americans, at a Bonferroni-corrected threshold of p<0·0055 (for rs2305480_G, odds ratio [OR] 1·36 [95% CI 1·12–1·65], p=0·0014; and for rs8076131_A, OR 1·37 [1·13–1·67], p=0·0010). In upper airway epithelial cells from African American children, genotype at rs2305480 was the most significant eQTL for GSDMB (eQTL effect size [β] 1·35 [95% CI 1·25–1·46], p<0·0001), and to a lesser extent showed an eQTL effect for post-GPI attachment to proteins phospholipase 3 (β 1·15 [1·08–1·22], p<0·0001). No SNPs were eQTLs for ORMDL3. By contrast, in PBMCs, the five core SNPs were associated only with expression of GSDMB and ORMDL3. Genotype at rs12936231 (in zona pellucida binding protein 2) showed the strongest associations across both genes (for GSDMB, eQTLβ 1·24 [1·15–1·32], p<0·0001; and for ORMDL3 (β 1·19 [1·12–1·24], p<0·0001). The eQTL effects of rs2305480 on GSDMB expression were replicated in lower airway cells from African American adults (β 1·29 [1·15–1·44], p<0·0001). Interpretation: Our study suggests that SNPs regulating GSDMB expression in airway epithelial cells have a major role in childhood-onset asthma, whereas SNPs regulating the expression levels of 17q12–21 genes in resting blood cells are not central to asthma risk. Our genetic and gene expression data in African Americans and European Americans indicated GSDMB to be the leading candidate gene at this important asthma locus.6 month embargo; published: 01 May 2020This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]