522 research outputs found
The Rectal Gland in Relation to the Osmoregulatory Mechanisms of Marine and Freshwater Elasmobranchs
- Author
- Publication venue
- DigitalCommons@University of Nebraska - Lincoln
- Publication date
- 01/01/1976
- Field of study
Get PDFThe rectal gland of elasmobranchs secretes large quantities of electrolytes and is of primary importance in the osmoregulatory mechanisms of these animals (Burger and Hess, 1960; Burger, 1962). Analogously, various organs of other vertebrates are also known to be involved in salt secretion (Schmidt-Nielsen, 1965; Bonting, 1970; Bentley, 1971). In general, active ion transport is the basis of this phenomenon; in any case, it requires the presence of structural devices, morphologically and chemically well defined, and of metabolic capabilities which, taken singly, are not specific, but collectively are consistent with active ion transport and salt secretion
Measurement of the Z/gamma* + b-jet cross section in pp collisions at 7 TeV
- Author
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe production of b jets in association with a Z/gamma* boson is studied
using proton-proton collisions delivered by the LHC at a centre-of-mass energy
of 7 TeV and recorded by the CMS detector. The inclusive cross section for
Z/gamma* + b-jet production is measured in a sample corresponding to an
integrated luminosity of 2.2 inverse femtobarns. The Z/gamma* + b-jet cross
section with Z/gamma* to ll (where ll = ee or mu mu) for events with the
invariant mass 60 < M(ll) < 120 GeV, at least one b jet at the hadron level
with pT > 25 GeV and abs(eta) < 2.1, and a separation between the leptons and
the jets of Delta R > 0.5 is found to be 5.84 +/- 0.08 (stat.) +/- 0.72 (syst.)
+(0.25)/-(0.55) (theory) pb. The kinematic properties of the events are also
studied and found to be in agreement with the predictions made by the MadGraph
event generator with the parton shower and the hadronisation performed by
PYTHIA.Comment: Submitted to the Journal of High Energy Physic
Compressed representation of a partially defined integer function over multiple arguments
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- Publication venue
- Publication date
- 01/01/2013
- Field of study
Get PDFIn OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
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- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
- Zielinski M
- Zito G
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFThe azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Adair A
- Adam N
- Adam W
- Adams JR
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- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
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- Yoo J
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
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- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
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- Zhukov V
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- Zielinski M
- Zito G
- Zou W
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
Get PDFA search for new physics is performed in events with two same-sign isolated
leptons, hadronic jets, and missing transverse energy in the final state. The
analysis is based on a data sample corresponding to an integrated luminosity of
4.98 inverse femtobarns produced in pp collisions at a center-of-mass energy of
7 TeV collected by the CMS experiment at the LHC. This constitutes a factor of
140 increase in integrated luminosity over previously published results. The
observed yields agree with the standard model predictions and thus no evidence
for new physics is found. The observations are used to set upper limits on
possible new physics contributions and to constrain supersymmetric models. To
facilitate the interpretation of the data in a broader range of new physics
scenarios, information on the event selection, detector response, and
efficiencies is provided.Comment: Published in Physical Review Letter
Measurement of jet fragmentation into charged particles in pp and PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
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- Adam W
- Adams JR
- Adams MR
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- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
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- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
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- Andrea J
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- Andreev Y
- Andrews W
- Anghel IM
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- Appelt E
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- Avetisyan A
- Avila C
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- Azhgirey I
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- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
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- Baden A
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- Bagliesi G
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- Bilki B
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Get PDFJet fragmentation in pp and PbPb collisions at a centre-of-mass energy of
2.76 TeV per nucleon pair was studied using data collected with the CMS
detector at the LHC. Fragmentation functions are constructed using
charged-particle tracks with transverse momenta pt > 4 GeV for dijet events
with a leading jet of pt > 100 GeV. The fragmentation functions in PbPb events
are compared to those in pp data as a function of collision centrality, as well
as dijet-pt imbalance. Special emphasis is placed on the most central PbPb
events including dijets with unbalanced momentum, indicative of energy loss of
the hard scattered parent partons. The fragmentation patterns for both the
leading and subleading jets in PbPb collisions agree with those seen in pp data
at 2.76 TeV. The results provide evidence that, despite the large parton energy
loss observed in PbPb collisions, the partition of the remaining momentum
within the jet cone into high-pt particles is not strongly modified in
comparison to that observed for jets in vacuum.Comment: Submitted to the Journal of High Energy Physic
Performance and Operation of the CMS Electromagnetic Calorimeter
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- Wayne M.
- Weber M.
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- Wenger E. A.
- Wenman D.
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- Wetzel J.
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- Whitmore J.
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- Wilken R.
- Wilkinson R.
- Williams G.
- Williams J. C.
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- Willmott C.
- Wimpenny S.
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- Wyslouch B.
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- Yetkin T.
- Yi K.
- Yilmaz Y.
- Yohay R.
- Yoo H. D.
- Yoon A. S.
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- Yumiceva F.
- Yun J. C.
- Yuste C.
- Zabi A.
- Zabi A.
- Zabolotny W.
- Zachariadou A.
- Zalewski P.
- Zampieri A.
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- Zarubin A.
- Zatzerklyany A.
- Zeidler C.
- Zeidler C.
- Zeinali M.
- Zeise M.
- Zelepoukine S.
- Zeuner W. D.
- Zeyrek M.
- Zhang J.
- Zhang L.
- Zhang Y.
- Zhang Z.
- Zheng Y.
- Zhiltsov V.
- Zhokin A.
- Zhu B.
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- Zhu R. Y.
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- Zhukova V.
- Ziebarth E. B.
- Zielinski M.
- Zilizi G.
- Zinonos Z.
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- 'IOP Publishing'
- Publication date
- 01/01/1
- Field of study
Get PDFThe operation and general performance of the CMS electromagnetic calorimeter
using cosmic-ray muons are described. These muons were recorded after the
closure of the CMS detector in late 2008. The calorimeter is made of lead
tungstate crystals and the overall status of the 75848 channels corresponding
to the barrel and endcap detectors is reported. The stability of crucial
operational parameters, such as high voltage, temperature and electronic noise,
is summarised and the performance of the light monitoring system is presented
Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis
- Author
- A De Grassi
- A Goel
- Amanda Ewart Toland
- Andrea Wunderlich
- Andreas W. Kuss
- Axel Fischer
- B Langmead
- Bernd Timmermann
- Bernhard G. Herrmann
- C Greenman
- Christian Barmeyer
- Christina Roehr
- D Fallik
- DJ Hedges
- ED Pleasance
- ED Pleasance
- ES Venkatraman
- F Kiefer
- Hans Lehrach
- HT Lynch
- IA Adzhubei
- Jana Koenig
- JM Schwarz
- JR Howe
- JR Howe
- JR Howe
- Kathrin Trappe
- Kurt Zatloukal
- L Shen
- LA Aaltonen
- Lars Bertram
- LD Wood
- LJ Jonk
- M Hampf
- M Stiller
- M Toyota
- MA Peinado
- Martin Kerick
- Martin Werber
- Masoud Garshasbi
- Melanie Isau
- Michael Lappe
- Michal R. Schweiger
- MR Schweiger
- Petra Seemann
- PM Krawitz
- S Jones
- S Markowitz
- SA Hahn
- SB Ng
- SM Lipkin
- SN Thibodeau
- SP Shah
- Stefan T. Boerno
- T Sjoblom
- TJ Ley
- U Pieper
- WF Bodmer
- Y Ionov
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Get PDFBACKGROUND: Colorectal cancer (CRC) is with approximately 1 million cases the third most common cancer worldwide. Extensive research is ongoing to decipher the underlying genetic patterns with the hope to improve early cancer diagnosis and treatment. In this direction, the recent progress in next generation sequencing technologies has revolutionized the field of cancer genomics. However, one caveat of these studies remains the large amount of genetic variations identified and their interpretation. METHODOLOGY/PRINCIPAL FINDINGS: Here we present the first work on whole exome NGS of primary colon cancers. We performed 454 whole exome pyrosequencing of tumor as well as adjacent not affected normal colonic tissue from microsatellite stable (MSS) and microsatellite instable (MSI) colon cancer patients and identified more than 50,000 small nucleotide variations for each tissue. According to predictions based on MSS and MSI pathomechanisms we identified eight times more somatic non-synonymous variations in MSI cancers than in MSS and we were able to reproduce the result in four additional CRCs. Our bioinformatics filtering approach narrowed down the rate of most significant mutations to 359 for MSI and 45 for MSS CRCs with predicted altered protein functions. In both CRCs, MSI and MSS, we found somatic mutations in the intracellular kinase domain of bone morphogenetic protein receptor 1A, BMPR1A, a gene where so far germline mutations are associated with juvenile polyposis syndrome, and show that the mutations functionally impair the protein function. CONCLUSIONS/SIGNIFICANCE: We conclude that with deep sequencing of tumor exomes one may be able to predict the microsatellite status of CRC and in addition identify potentially clinically relevant mutations
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Diet and exercise changes following direct-to-consumer personal genomic testing
- Author
- Braunstein Glenn
- Carere Deanna Alexis
- Chen Clara A.
- Christensen Kurt D.
- Couper Mick P.
- Crawford Scott D.
- Cupples L. Adrienne
- Gollust Sarah
- Gray Stacy W.
- Green Robert C.
- Kalia Sarah S.
- Kaphingst Kimberly
- Kiefer Amy K.
- Koenig Barbara A.
- Kraft Peter
- Krier Joel B.
- Le Lan Q.
- Lehmann Lisa S.
- Mountain Joanna L.
- Nielsen Daiva E.
- Nielsen Daiva Elena
- Ostergren Jenny
- Roberts J. Scott
- Ruffin Mack T.
- Uhlmann Wendy R.
- Wang Catharine
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 15/06/2017
- Field of study
Get PDFBackground: The impacts of direct-to-consumer personal genomic testing (PGT) on health behaviors such as diet and exercise are poorly understood. Our investigation aimed to evaluate diet and exercise changes following PGT and to determine if changes were associated with genetic test results obtained from PGT. Methods: Customers of 23andMe and Pathway Genomics completed a web-based survey prior to receiving PGT results (baseline) and 6 months post-results. Fruit and vegetable intake (servings/day), and light, vigorous and strength exercise frequency (days/week) were assessed. Changes in diet and exercise were examined using paired t-tests and linear regressions. Additional analyses examined whether outcomes differed by baseline self-reported health (SRH) or content of PGT results. Results: Longitudinal data were available for 1,002 participants. Significant increases were observed for vegetable intake (mean Î = 0.11 (95% CI = 0.05, 0.17), p = 0.0003) and strength exercise (Î = 0.14 (0.03, 0.25), p = 0.0153). When stratified by SRH, significant increases were observed for all outcomes among lower SRH participants: fruit intake, Î = 0.11 (0.02, 0.21), p = 0.0148; vegetable intake, Î = 0.16 (0.07, 0.25), p = 0.0005; light exercise, Î = 0.25 (0.03, 0.47), p = 0.0263; vigorous exercise, Î = 0.23 (0.06, 0.41), p = 0.0097; strength exercise, Î = 0.19 (0.01, 0.37), p = 0.0369. A significant change among higher SRH participants was only observed for light exercise, and in the opposite direction: Î = -0.2468 (-0.06, -0.44), p = 0.0111. Genetic results were not consistently associated with any diet or exercise changes. Conclusions: The experience of PGT was associated with modest, mostly positive changes in diet and exercise. Associations were independent of genetic results from PGT
Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses
- Author
- Afzal Shoaib
- Akwo Elvis A.
- Allara Elias
- Almeida Osvaldo
- Altay Servet
- Amiano Pilar
- Arndt Volker
- Arndt Volker
- Arnold Matthew
- Arriscado Cristina Martin
- Aspelund Thor
- Atkins Robert
- Baigent Colin
- Barr Elizabeth L.m.
- Bell Steven
- BjĂśrkelund Cecilia
- Boer Jolanda M.a.
- Bolton Thomas R.
- Brenner Hermann
- Burgess Stephen
- Butterworth Adam S.
- Can GĂźnay
- Casas Juan P.
- Casiglia Edoardo
- Casiglia Edoardo
- Chaker Layal
- Chen Lingyan
- Chetrit Angela
- Chiodini Paolo
- Cho Kelly
- Cooper Jackie A.
- Cooper Jackie A.
- Coresh Josef
- Cushman Mary
- Cushman Mary
- Damrauer Scott M.
- Danesh John
- Dankner Rachel
- Davidson Karina W.
- De Jongh Renate T.
- De La CĂĄmara AgustĂn GĂłmez
- Di Angelantonio Emanuele
- Donfrancesco Chiara
- Donfrancesco Chiara
- Edwards Todd L.
- EngstrĂśm Gunnar
- Ferreiro Carmen Romero
- Feskens Edith
- Flicker Leon
- Freisling Heinz
- Furuta Yoshihiko
- Gagnon David R.
- Garcia Jose RamĂłn QuirĂłs
- Gaziano J.michael
- Gaziano Liam
- Gaziano Thomas A.
- Geleijnse Johanna M
- Gudnason Vilmundur
- Hange Dominique
- Hankey Graeme J.
- Hansson Per-olof
- Harrison Seamus
- Hata Jun
- Hayama-terada Mina
- Heath Alicia K.
- Hedblad Bo
- Holleczek Bernd
- Honda Takanori
- Hoorn Ewout J.
- Hung Adriana M.
- Ikram Kamran M.
- Imano Hironori
- Inouye Michael
- Ishizaki Masao
- Iso Hiroyasu
- Iso Hiroyasu
- Jassal Simerjot
- Jassal Simerjot K.
- Joseph Jacob
- Kaaks Rudolf
- Kaptoge Stephen K.
- Katzke Verena
- Kauhanen Jussi
- Kavousi Maryam
- Kiechl Stefan
- Kitamura Akihiko
- Koenig Wolfgang
- Koenig Wolfgang
- Koettgen Anna
- Kromhout Daan
- Kronmal Richard
- Kronmal Richard A.
- Kyrø Cecilie
- Langenberg Claudia
- Lappas Georg
- Lawlor Deborah A.
- Leitner Christoph
- Lissner Lauren
- Ljungberg BĂśrje
- Lo Noce Cinzia
- Macdonald Conor
- Masala Giovanna
- Mason Amy M.
- Mehlig Kirsten
- Meisinger Christa
- Meisinger Christa
- Melander Olle
- Melander Olle
- Monique Verschuren W.m.
- Moreno Iribas Conchi
- Morikawa Yuko
- Mosconi Katja
- Muraki Isao
- Muralidhar Sumitra
- Nagel Dorothea
- Nakagawa Hideaki
- Nilsson Peter M.
- Ninomiya Toshiharu
- Nitsch Dorothea
- Nitsch Dorothea
- Nordestgaard Børge G.
- Norman Paul E.
- Onland-moret Charlotte
- Pablos David Lora
- Palmieri Luigi
- Palmieri Luigi
- Pennells Lisa
- Petrova Dafina
- Posner Daniel C.
- Pyarajan Saiju
- Riboli Elio
- Robinson-cohen Cassianne
- Rosengren Annika
- Sacerdote Carlotta
- Sakurai Masaru
- Salonen Jukka T.
- Santiuste Carmen
- Sato Shinichi
- Schnohr Peter
- Schubert Petra
- Schulze Matthias B.
- Schwartz Joseph
- SchĂśttker Ben
- Shaffer Jonathan
- Shaw Jonathan
- Shimbo Daichi
- Sieri Sabina
- Sigurdsson Gunnar
- Song Rebecca J.
- Staley James R.
- Staplin Natalie
- Stocker Hannah
- Sun Luanluan
- SundstrĂśm Johan
- Svärdsudd Kurt
- Svärdsudd Kurt
- Tao Ran
- Thorsson Bolli
- Tikhonoff ValĂŠrie
- Tikhonoff ValĂŠrie
- Tjønneland Anne
- Tong Tammy
- Tsao Philip S.
- Tumino Rosario
- Tunstall-pedoe Hugh
- Tuomainen Tomi-pekka
- Tybjaerg-hansen Anne
- Tzoulaki Ioanna
- Van Der Schouw Yvonne T.
- Van Schoor N. M.
- Van Zutphen E. M.
- VĂślzke Henry
- VĂślzke Henry
- Wallace Robert B.
- Wallace Robert B.
- Wannamethee S. Goya
- Wareham Nick
- Weiderpass Elisabete
- Welin Lennart
- Welin Lennart
- Whincup Peter
- Willeit Johann
- Willeit Peter
- Willeit Peter
- Wilson Peter W.f.
- Wood Angela M.
- Woodward Mark
- Woodward Mark
- Yamagishi Kazumasa
- YĂźksel HĂźsniye
- Zamora-ros Raul
- Zimmet Paul
- ĂrnlĂśv Johan
- ĂrnlĂśv Johan
- Ăzkan UÄur
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 16/01/2023
- Field of study
Full text linkBACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million personyears of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eG FR values 105 mL.min(-1).1.73 m(-2), compared with those with eG FR between 60 and 105 mL.min(-1).1.73 m(-2). Mendelian randomization analyses for CHD showed an association among participants with eGFR 105 mL.min(-1).1.73 m(-2). Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin Alc, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function
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