ヒトナチュラル・キラー（NK）細胞の電顕的考察

An electron microscopic study of human natural killer (NK) cells showed abundant cytoplasm and relatively large mitochondria. They also had various kinds of granules in their cytoplasm. The mode of binding to the tumor cell (K 562) was tight, and villi protruded from NK cells to the target cells. Some target cells were already lysed after incubation for 5 minutes at 4°C.This work was supported in parts by Grants-in-Aid for Scientific Research (Project Nos. 544050 and 56770468) from the Ministry of Education, Science and Culture of Japan

マイコプラスマ肺炎に合併した脳梗塞の1例

A 4-year-old boy developed right hemiplegia and aphasia during Mycoplasma pneumoniae (M. pneumoniae) infection. Computed tomography of the brain showed a large cerebral infarction of the left temporal area. Carotid angiography revealed an obstruction of a branch of the left middle cerebral artery. The possible pathogenesis of central nervous system (CNS) symptoms due to M pneumoniae infection is discussed

リンパ球活性化におけるコンカナバリンAの接触時間に対するノイラミニダーゼの作用

Neuraminidase-treatment greatly increased 3H-thymidine incorporation by human lymphocytes at lower concentrations of Con A. An irreversible sequence after 24 hr of incubation in the presence of the optimal concentration of Con A was found. However, at a suboptimal concantraiton of Con A, neuraminidase-treated lymphocytes exposed to Con A for 72 hr exhibited a greater magnitude of 3H-thymidine incorporation in contrast to the neuraminidase-treated lymphocytes exposed to Con A for 24 hr, indicating that the enancement effect of neuraminidase was not due to the increased binding of Con A to cell surfaces.This work was supported in part by Grant-in-Aid for Scientific Research (Project Nos. 544050 and 577401) from the Ministry of Education, Science and Culture of Japan

正常ヒト未梢血リンパ球のナチュラル・キラー活性について : I. アンモニウムクロライドによる活性抑制機序の検討

The inhibitory effect of ammonium choride pretreatment of human peripheral blood lymphocytes on natural killer (NK) activity to myeloid leukemic cell line K-562 was studied. The more dilute the ammonium chloride solution, the less was the inhibitory effect on NK activity. This inhibitory effect was weaker when effector cells were treated at 4°C than at 37°C. Inhibited NK activity recovered partially after incubation for 24 hours.This work was supported by a Research Grant (No. 544050) from the Ministry of Education, Science and Culture of Japan