145 research outputs found
湿度の最大化手法による可能最大降水量推定の不確実性分析
京都大学新制・課程博士博士(工学)甲第23164号工博第4808号新制||工||1752(附属図書館)京都大学大学院工学研究科社会基盤工学専攻(主査)教授 立川 康人, 准教授 KIM SUNMIN, 教授 中北 英一学位規則第4条第1項該当Doctor of Philosophy (Engineering)Kyoto UniversityDFA
Effect of Enhanced Grain Refinement in Friction Welded SUS316L Alloy
To investigate the solid state weldability on SUS316L alloy, this work was carried out. Friction welding as a solid state welding was introduced and conducted at a rotation speed of 2,000 rpm and a friction pressure of 25 MPa on tube typed specimens. After this work, the grain boundary characteristic distributions such a grain size, shape and misorientation angle of the welds were clarified by electron backscattering diffraction method. The application of friction welding on SUS316L resulted in a significant refinement of the grain size in the weld zone (6.03 μm) compared to that of the base material (57.55 μm). Despite the grain refinement, the mechanical properties of the welds indicate relatively low or similar to the base material. These mechanical properties are due to dislocation density in the initial material and grain refinement in the welds
Continuous particle separation using pressure-driven flow-induced miniaturizing free-flow electrophoresis
In this paper, we introduce pressure-driven flow-induced miniaturizing free-flow electrophoresis (PDF-induced mu-FFE), a novel continuous separation method. In our separation system, the external flow and electric field are applied to particles, such that particle movement is affected by pressure-driven flow, electroosmosis, and electrophoresis. We then analyzed the hydrodynamic drag force and electrophoretic force applied to the particles in opposite directions. Based on this analysis, micro-and nano-sized particles were separated according to their electrophoretic mobilities with high separation efficiency. Because the separation can be achieved in a simple T-shaped microchannel, without the use of internal electrodes, it offers the advantages of low-cost, simple device fabrication and bubble-free operation, compared with conventional mu-FFE methods. Therefore, we expect the proposed separation method to have a wide range of filtering/separation applications in biochemical analysis.open1185sciescopu
Reading Single DNA with DNA Polymerase Followed by Atomic Force Microscopy
The importance of DNA sequencing in the life sciences and personalized medicine is continually increasing. Single-molecule sequencing methods have been developed to analyze DNA directly without the need for amplification. Here, we present a new approach to sequencing single DNA molecules using atomic force microscopy (AFM). In our approach, four surface conjugated nucleotides were examined sequentially with a DNA polymerase immobilized AFM tip. By observing the specific rupture events upon examination of a matching nucleotide, we could determine the template base bound in the polymerase's active site. The subsequent incorporation of the complementary base in solution enabled the next base to be read. Additionally, we observed that the DNA polymerase could incorporate the surface-conjugated dGTP when the applied force was controlled by employing the force-clamp mode.X1114Ysciescopu
Two-qubit spectroscopy of spatiotemporally correlated quantum noise in superconducting qubits
Noise that exhibits significant temporal and spatial correlations across
multiple qubits can be especially harmful to both fault-tolerant quantum
computation and quantum-enhanced metrology. However, a complete spectral
characterization of the noise environment of even a two-qubit system has not
been reported thus far. We propose and experimentally validate a protocol for
two-qubit dephasing noise spectroscopy based on continuous control modulation.
By combining ideas from spin-locking relaxometry with a statistically motivated
robust estimation approach, our protocol allows for the simultaneous
reconstruction of all the single-qubit and two-qubit cross-correlation spectra,
including access to their distinctive non-classical features. Only single-qubit
control manipulations and state-tomography measurements are employed, with no
need for entangled-state preparation or readout of two-qubit observables. While
our experimental validation uses two superconducting qubits coupled to a shared
engineered noise source, our methodology is portable to a variety of
dephasing-dominated qubit architectures. By pushing quantum noise spectroscopy
beyond the single-qubit setting, our work paves the way to characterizing
spatiotemporal correlations in both engineered and naturally occurring noise
environments.Comment: total: 22 pages, 7 figures; main: 13 pages, 6 figures, supplementary:
6 pages, 1 figure; references: 3 page
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