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Clinical Decision Support Functions and Digitalization of Clinical Documents of Electronic Medical Record Systems
Objectives
The objective of this study was to investigate the clinical decision support (CDS) functions and digitalization of clinical documents of Electronic Medical Record (EMR) systems in Korea. This exploratory study was conducted focusing on current status of EMR systems.
Methods
This study used a nationwide survey on EMR systems conducted from July 25, 2018 to September 30, 2018 in Korea. The unit of analysis was hospitals. Respondents of the survey were mainly medical recorders or staff members in departments of health insurance claims or information technology. This study analyzed data acquired from 132 hospitals that participated in the survey.
Results
This study found that approximately 80% of clinical documents were digitalized in both general and small hospitals. The percentages of general and small hospitals with 100% paperless medical charts were 33.7% and 38.2%, respectively. The EMR systems of general hospitals are more likely to have CDS functions of warnings regarding drug dosage, reminders of clinical schedules, and clinical guidelines compared to those of small hospitals; this difference was statistically significant. For the lists of digitalized clinical documents, almost 93% of EMR systems in general hospitals have the inpatient progress note, operation records, and discharge summary notes digitalized.
Conclusions
EMRs are becoming increasingly important. This study found that the functions and digital documentation of EMR systems still have a large gap, which should be improved and made more sophisticated. We hope that the results of this study will contribute to the development of more sophisticated EMR systems
Physical properties of transparent perovskite oxides (Ba,La)SnO3 with high electrical mobility at room temperature
Transparent electronic materials are increasingly in demand for a variety of
optoelectronic applications. BaSnO3 is a semiconducting oxide with a large band
gap of more than 3.1 eV. Recently, we discovered that La doped BaSnO3 exhibits
unusually high electrical mobility of 320 cm^2(Vs)^-1 at room temperature and
superior thermal stability at high temperatures [H. J. Kim et al. Appl. Phys.
Express. 5, 061102 (2012)]. Following that work, we report various physical
properties of (Ba,La)SnO3 single crystals and films including
temperature-dependent transport and phonon properties, optical properties and
first-principles calculations. We find that almost doping-independent mobility
of 200-300 cm^2(Vs)^-1 is realized in the single crystals in a broad doping
range from 1.0x10^19 to 4.0x10^20 cm^-3. Moreover, the conductivity of ~10^4
ohm^-1cm^-1 reached at the latter carrier density is comparable to the highest
value. We attribute the high mobility to several physical properties of
(Ba,La)SnO3: a small effective mass coming from the ideal Sn-O-Sn bonding,
small disorder effects due to the doping away from the SnO2 conduction channel,
and reduced carrier scattering due to the high dielectric constant. The
observation of a reduced mobility of ~70 cm^2(Vs)^-1 in the film is mainly
attributed to additional carrier-scatterings which are presumably created by
the lattice mismatch between the substrate SrTiO3 and (Ba,La)SnO3. The main
optical gap of (Ba,La)SnO3 single crystals remained at about 3.33 eV and the
in-gap states only slightly increased, thus maintaining optical transparency in
the visible region. Based on these, we suggest that the doped BaSnO3 system
holds great potential for realizing all perovskite-based, transparent
high-frequency high-power functional devices as well as highly mobile
two-dimensional electron gas via interface control of heterostructured films.Comment: 31 pages, 7 figure
Dual priming oligonucleotide system for the multiplex detection of respiratory viruses and SNP genotyping of CYP2C19 gene
Successful PCR starts with proper priming between an oligonucleotide primer and the template DNA. However, the inevitable risk of mismatched priming cannot be avoided in the currently used primer system, even though considerable time and effort are devoted to primer design and optimization of reaction conditions. Here, we report a novel dual priming oligonucleotide (DPO) which contains two separate priming regions joined by a polydeoxyinosine linker. The linker assumes a bubble-like structure which itself is not involved in priming, but rather delineates the boundary between the two parts of the primer. This structure results in two primer segments with distinct annealing properties: a longer 5ā²-segment that initiates stable priming, and a short 3ā²-segment that determines target-specific extension. This DPO-based system is a fundamental tool for blocking extension of non-specifically primed templates, and thereby generates consistently high PCR specificity even under less than optimal PCR conditions. The strength and utility of the DPO system are demonstrated here using multiplex PCR and SNP genotyping PCR
High Mobility in a Stable Transparent Perovskite Oxide
We discovered that La-doped BaSnO3 with the perovskite structure has an
unprecedentedly high mobility at room temperature while retaining its optical
transparency. In single crystals, the mobility reached 320 cm^2(Vs)^-1 at a
doping level of 8x10^19 cm^-3, constituting the highest value among
wide-band-gap semiconductors. In epitaxial films, the maximum mobility was 70
cm^2(Vs)^-1 at a doping level of 4.4x10^20 cm^-3. We also show that resistance
of (Ba,La)SnO3 changes little even after a thermal cycle to 530 Deg. C in air,
pointing to an unusual stability of oxygen atoms and great potential for
realizing transparent high-frequency, high-power functional devices.Comment: 15 pages, 3 figure
HER2, estrogen receptor-negative metastatic hidradenocarcinoma: identification of TP53 mutation in both primary and cell-free DNA
Hidradenocarcinoma is an extremely rare cutaneous skin carcinoma which arise from the sweat gland. There are several report about potential targets in this rare disease including estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2). A 53-year-old man who presented with a slowly growing mass on the left thumb which was pathologically confirmed of HER2 negative, ER negative hidradenocarcinoma. At the time of presentation, the patient had metastatic lesions to lung and axillary lymph nodes. The patient received several lines of palliative chemotherapy and radiotherapy, but died of the disease progression. We identified TP53 G245S mutation in both primary tumor specimen and cell-free based targeted sequencing. Herein, we report on a very rare case of metastatic hidradenocarcinoma with TP53 G245S mutation but no other treatable targets from clinical sequencing, which pursued an aggressive clinical course
Intraductal Tubular Carcinoma of the Pancreas: a Case Report with the Imaging Findings
We describe here a case of intraductal tubular carcinoma of the main pancreatic duct. Gadolinium-enhanced pancreas magnetic resonance (MR) imaging showed an enhancing mass that was confined in the dilated main pancreatic duct of the pancreatic body, along with dilatation of the upstream main pancreatic duct and chronic pancreatitis that was due to obstruction. MR cholangiopancreatography and an endoscopic retrograde pancreatogram showed a filling defect that was due to an intraductal mass of the pancreatic body, along with dilatation of the upstream main pancreatic duct and no dilatation of the downstream main pancreatic duct. The pathological findings demonstrated an intraductal nodular appearance without papillary projection or mucin hypersecretion
Bronchus-Associated Lymphoid Tissue (BALT) Lymphoma of the Lung Showing Mosaic Pattern of Inhomogeneous Attenuation on Thin-section CT: A Case Report
The authors present a case of histologically proven bronchus-associated lymphoid tissue (BALT) lymphoma of the lung in a patient with primary Sjƶgren's syndrome that manifested on thin-section CT scan as a mosaic pattern of inhomogeneous attenuation due to mixed small airway and infiltrative abnormalitie
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