524 research outputs found
Self-heating of Strongly Interacting Massive Particles
It was recently pointed out that semi-annihilating dark matter (DM) may
experience a novel temperature evolution dubbed as self-heating. Exothermic
semi-annihilation converts the DM mass to the kinetic energy. This yields a
unique DM temperature evolution, , in contrast to for free-streaming non-relativistic particles.
Self-heating continues as long as self-scattering sufficiently redistributes
the energy of DM particles. In this paper, we study the evolution of
cosmological perturbations in self-heating DM. We find that sub-GeV
self-heating DM leaves a cutoff on the subgalactic scale of the matter power
spectrum when the self-scattering cross section is . Then we present a particle
physics realization of the self-heating DM scenario. The model is based on
recently proposed strongly interacting massive particles with pion-like
particles in a QCD-like sector. Pion-like particles semi-annihilate into an
axion-like particle, which is thermalized with dark radiation. The dark
radiation temperature is smaller than the standard model temperature, evading
the constraint from the effective number of neutrino degrees of freedom. It is
easily realized when the dark sector is populated from the standard model
sector through a small coupling.Comment: 25 pages, 5 figures; minor corrections, version accepted in PR
Late-time magnetogenesis driven by ALP dark matter and dark photon
We propose a mechanism generating primordial magnetic fields after the
annihilations. Our mechanism involves an ultra-light axion-like
particle (ALP) which constitutes the dark matter, and a dark gauge
boson introduced to bypass the obstacle placed by the conductivity of cosmic
plasma. In our scheme, a coherently oscillating ALP amplifies the dark photon
field, and part of the amplified dark photon field is concurrently converted to
the ordinary magnetic field through the ALP-induced magnetic mixing. For the
relevant ALP mass range , our mechanism can generate with a coherent length kpc, which is large enough to provide a seed of the galactic
magnetic fields. The mechanism also predicts a dark electromagnetic
field , which
can result in interesting astrophysical/cosmological phenomena by inducing the
mixings between the ALP, ordinary photon, and dark photon states.Comment: 6 pages, 2 figures; discussions rearranged, minor numerical errors
fixed, conclusion unchanged; discussion improved, accepted for publication in
PR
Regulation of BAX/BAK-Dependent Cell Death Program
Mammals have evolved an intricate regulation of a genetically programmed apoptotic cell death that involves mitochondria. Diverse apoptotic signals converge on mitochondria, which causes the release of cytochrome c into the cytosol to activate Apaf-1. This initiates caspase activation, which results in irreversible cellular demise. The BCL-2 family proteins constitute a critical checkpoint in mitochondrion-dependent apoptosis. Multidomain proapoptotic BAX/BAK promotes mitochondrial outer membrane permeabilization, whereas anti-apoptotic BCL-2/BCL-XL/MCL-1 protects mitochondrial integrity and prevents cytochrome c release. The proapoptotic activity of BAX/BAK is triggered by BH3-only molecules: BH3s) which are upregulated by upstream death signals. However, how these subfamilies interact with one another to execute mitochondrial cell death remains unclear. Thus, this thesis aims at elucidating the mechanism regarding how the interplay between BCL-2 subfamilies determines cellular commitment to survival versus death and how BAX/BAK activation is triggered by BH3s. Our laboratory showed that BH3s can be further classified into two subclasses- `activator\u27 tBID/BIM/PUMA that directly activates BAX/BAK to induce cytochrome c release and `inactivator\u27 BH3s that antagonize the function of anti-apoptotic BCL-2 members. Here, a BAX/BAK mutagenesis study indicated that anti-apoptotic BCL-2 members prevent BAX/BAK activation by sequestering activator BH3s rather than by directly binding to BAX/BAK. I further demonstrated that inactivator BH3s are able to displace activator BH3s from anti-apoptotic BCL-2 members with unique specificity, thus preventing their sequestration of activator BH3s. Activator BH3s were shown to act downstream of inactivator BH3s to trigger BAX/BAK activation, establishing the hierarchy of BCL-2 subfamilies in regulating mitochondrial apoptosis. Then, I investigated the molecular mechanism whereby BAX/BAK is activated by activator BH3s. I demonstrated that BAX undergoes stepwise structural reorganization leading to two activation processes-mitochondrial targeting and homo-oligomerization. Activator BH3s initiate BAX activation by attacking and exposing Ξ±1 helix of BAX leading to the secondary disengagement of the Ξ±9 helix and mitochondrial translocation. Activator BH3s remain associated with BAX to drive homo-oligomerization at the mitochondria. BAK has bypassed the first activation step, but requires activator BH3s for homo-oligomerization. This study further emphasizes the direct engagement of activator BH3s in BAX/BAK-dependent mitochondrial apoptotic pathway. Lastly, our laboratory showed that BH3s trigger caspase-independent mitochondrial dysfunction only in the presence of BAX/BAK. I found that BAK exists as several distinct complexes at the mitochondria, one of which is functionally different from cytochrome c-releasing BAK oligomers but instead includes VDAC/ANT channels that regulate ATP/ADP transport to support ATP production by oxidative phosphorylation. tBID overexpression induces cell death in the absence of Apaf-1 by inhibiting VDAC-mediated ADP import into the mitochondria in a BAK-dependent manner, suggesting that activated BAK antagonizes VDAC activity to initiate mitochondrial dysfunction. This study provides novel insights into how BAK activation couples apoptosis and mitochondrial dysfunction to trigger cell death
Self-heating dark matter via semi-annihilation
The freeze-out of dark matter (DM) depends on the evolution of the DM
temperature. The DM temperature does not have to follow the standard model one,
when the elastic scattering is not sufficient to maintain the kinetic
equilibrium. We study the temperature evolution of the semi-annihilating DM,
where a pair of the DM particles annihilate into one DM particle and another
particle coupled to the standard model sector. We find that the kinetic
equilibrium is maintained solely via semi-annihilation until the last stage of
the freeze-out. After the freeze-out, semi-annihilation converts the mass
deficit to the kinetic energy of DM, which leads to non-trivial evolution of
the DM temperature. We argue that the DM temperature redshifts like radiation
as long as the DM self-interaction is efficient. We dub this novel temperature
evolution as self-heating. Notably, the structure formation is suppressed at
subgalactic scales like keV-scale warm DM but with GeV-scale self-heating DM if
the self-heating lasts roughly until the matter-radiation equality. The long
duration of the self-heating requires the large self-scattering cross section,
which in turn flattens the DM density profile in inner halos. Consequently,
self-heating DM can be a unified solution to apparent failures of cold DM to
reproduce the observed subgalactic scale structure of the Universe.Comment: 6 pages, 4 figures. v2: discussed improved, matches published versio
Axion-like particle assisted strongly interacting massive particle
We propose a new realization of strongly interacting massive particles (SIMP)
as self-interacting dark matter, where SIMPs couple to the Standard Model
sector through an axion-like particle. Our model gets over major obstacles
accompanying the original SIMP model, such as a missing mechanism of
kinetically equilibrating SIMPs with the SM plasma as well as marginal
perturbativity of the chiral Lagrangian density. Remarkably, the parameter
region realizing is within the reach of future beam dump experiments such as
the Search for Hidden Particles (SHiP) experiment.Comment: 11 pages, 1 figure. v2: figure updated, discussions improve
Dynamics of the cosmological relaxation after reheating
We examine if the cosmological relaxation mechanism, which was proposed
recently as a new solution to the hierarchy problem, can be compatible with
high reheating temperature well above the weak scale. As the barrier potential
disappears at high temperature, the relaxion rolls down further after the
reheating, which may ruin the successful implementation of the relaxation
mechanism. It is noted that if the relaxion is coupled to a dark gauge boson,
the new frictional force arising from dark gauge boson production can
efficiently slow down the relaxion motion, which allows the relaxion to be
stabilized after the electroweak phase transition for a wide range of model
parameters, while satisfying the known observational constraints.Comment: 10 pages, 4 figures; minor revisions, version published in PR
Gravitational Interaction of Ultralight Dark Matter with Interferometers
Ultralight dark matter exhibits an order-one density fluctuation over the
spatial scale of its wavelength. These fluctuations gravitationally interact
with gravitational wave interferometers, leading to an additional noise floor
or signals. We investigate the ultralight dark matter-induced effects in the
gravitational wave interferometers. We perform a systematic computation of the
power spectrum of ultralight dark matter in interferometers. We show that the
ultralight dark matter-induced effect is most relevant for the interferometers
with long baseline and that it only constitutes a sub-leading noise floor
compared to the estimated noise level in the case of Laser Interferometer Space
Antenna or future interferometers with an arm-length comparable to a few
astronomical units. Gravitational wave interferometers can then place upper
limits on the ultralight dark matter density in the solar system. We find that,
under certain assumptions, future interferometers with AU-scale arm-length
might probe the dark matter density a few hundred times the local dark matter
density, which is measured over a much larger spatial scale.Comment: 20 pages, 5 figure
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