Motion sickness susceptibility under weightless and hypergravity conditions generated by parabolic flight

Motion sickness susceptibility under weightless and hypergravity conditions generated by parabolic fligh

The X-ray R Aquarii: A Two-sided Jet and Central Source

We report Chandra ACIS-S3 x-ray imaging and spectroscopy of the R Aquarii binary system that show a spatially resolved two-sided jet and an unresolved central source. This is the first published report of such an x-ray jet seen in an evolved stellar system comprised of ~2-3 solar masses. At E < 1 keV, the x-ray jet extends both to the northeast and southwest relative to the central binary system. At 1 < E < 7.1 keV, R Aqr is a point-like source centered on the star system. While both 3.5-cm radio continuum emission and x-ray emission appear coincident in projection and have maximum intensities at ~7.5" northeast of the central binary system, the next strongest x-ray component is located \~30" southwest of the central binary system and has no radio continuum counterpart. The x-ray jets are likely shock heated in the recent past, and are not in thermal equilibrium. The strongest southwest x-ray jet component may have been shocked recently since there is no relic radio emission as expected from an older shock. At the position of the central binary, we detect x-ray emission below 1.6 keV consistent with blackbody emission at T ~2 x 10^6 K. At the central star there is also a prominent 6.4 keV feature, a possible fluorescence or collisionally excited Fe K-alpha line from an accretion disk or from the wind of the giant star. For this excitation to occur, there must be an unseen hard source of x-rays or particles in the immediate vicinity of the hot star. Such a source would be hidden from view by the surrounding edge-on accretion disk.Comment: PS, 20 pages, including 3 figures PNG, JPG - accepted for publication in ApJ Letters. Subject headings: stars: individual (R Aquarii) -- binaries: symbiotic -- circumstellar matter -- stars: white dwarfs -- stars: winds, outflows -- radio continuum: stars -- x-rays: genera

Vanishing Hall Resistance at High Magnetic Field in a Double Layer Two-Dimensional Electron System

At total Landau level filling factor $\nu_{tot}=1$ a double layer two-dimensional electron system with small interlayer separation supports a collective state possessing spontaneous interlayer phase coherence. This state exhibits the quantized Hall effect when equal electrical currents flow in parallel through the two layers. In contrast, if the currents in the two layers are equal, but oppositely directed, both the longitudinal and Hall resistances of each layer vanish in the low temperature limit. This finding supports the prediction that the ground state at $\nu_{tot}=1$ is an excitonic superfluid.Comment: 4 pages, 4 figure

Stainless super p-branes

The elementary and solitonic supersymmetric p-brane solutions to supergravity theories form families related by dimensional reduction, each headed by a maximal (`stainless') member that cannot be isotropically dimensionally oxidized into higher dimensions. We find several new families, headed by stainless solutions in various dimensions D\le 9. In some cases, these occur with dimensions (D,p) that coincide with those of descendants of known families, but since the new solutions are stainless, they are necessarily distinct. The new stainless supersymmetric solutions include a 6-brane and a 5-brane in D=9, a string in D=5, and particles in all dimensions 5\le D\le 9

Exploring affective design for physical controls

Physical controls such as knobs, sliders, and buttons are experiencing a revival as many computing systems progress from personal computing architectures towards ubiquitous computing architectures. We demonstrate a process for measuring and comparing visceral emotional responses of a physical control to performance results of a target acquisition task. In our user study, participants experienced mechanical and rendered friction, inertia, and detent dynamics as they turned a haptic knob towards graphical targets of two different widths and amplitudes. Together, this process and user study provide novel affect- and performance-based design guidance to developers of physical controls for emerging ubiquitous computing environments. Our work bridges extensive human factors work in mechanical systems that peaked in the 1960’s, to contemporary trends, with a goal of integrating mechatronic controls into emerging ubiquitous computing systems. Author Keywords Haptic display, physical control, design process, affect

Optimization algorithms for functional deimmunization of therapeutic proteins

<p>Abstract</p> <p>Background</p> <p>To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the response is the recognition and surface display by antigen-presenting cells of epitopes, short peptide fragments derived from the foreign protein. Thus, developing minimal-epitope variants represents a powerful approach to deimmunizing protein therapeutics. Critically, mutations selected to reduce immunogenicity must not interfere with the protein's therapeutic activity.</p> <p>Results</p> <p>This paper develops methods to improve the likelihood of simultaneously reducing the anti-biotherapeutic immune response while maintaining therapeutic activity. A dynamic programming approach identifies optimal and near-optimal sets of conservative point mutations to minimize the occurrence of predicted T-cell epitopes in a target protein. In contrast with existing methods, those described here integrate analysis of immunogenicity and stability/activity, are broadly applicable to any protein class, guarantee global optimality, and provide sufficient flexibility for users to limit the total number of mutations and target MHC alleles of interest. The input is simply the primary amino acid sequence of the therapeutic candidate, although crystal structures and protein family sequence alignments may also be input when available. The output is a scored list of sets of point mutations predicted to reduce the protein's immunogenicity while maintaining structure and function. We demonstrate the effectiveness of our approach in a number of case study applications, showing that, in general, our best variants are predicted to be better than those produced by previous deimmunization efforts in terms of either immunogenicity or stability, or both factors.</p> <p>Conclusions</p> <p>By developing global optimization algorithms leveraging well-established immunogenicity and stability prediction techniques, we provide the protein engineer with a mechanism for exploring the favorable sequence space near a targeted protein therapeutic. Our mechanism not only helps identify designs more likely to be effective, but also provides insights into the interrelated implications of design choices.</p

Spacecraft charging and ion wake formation in the near-Sun environment

A three-dimensional (3-D), self-consistent code is employed to solve for the static potential structure surrounding a spacecraft in a high photoelectron environment. The numerical solutions show that, under certain conditions, a spacecraft can take on a negative potential in spite of strong photoelectron currents. The negative potential is due to an electrostatic barrier near the surface of the spacecraft that can reflect a large fraction of the photoelectron flux back to the spacecraft. This electrostatic barrier forms if (1) the photoelectron density at the surface of the spacecraft greatly exceeds the ambient plasma density, (2) the spacecraft size is significantly larger than local Debye length of the photoelectrons, and (3) the thermal electron energy is much larger than the characteristic energy of the escaping photoelectrons. All of these conditions are present near the Sun. The numerical solutions also show that the spacecraft's negative potential can be amplified by an ion wake. The negative potential of the ion wake prevents secondary electrons from escaping the part of spacecraft in contact with the wake. These findings may be important for future spacecraft missions that go nearer to the Sun, such as Solar Orbiter and Solar Probe Plus.Comment: 25 pages, 7 figures, accepted for publication in Physics of Plasma

Mapping the Pareto Optimal Design Space for a Functionally Deimmunized Biotherapeutic Candidate

The immunogenicity of biotherapeutics can bottleneck development pipelines and poses a barrier to widespread clinical application. As a result, there is a growing need for improved deimmunization technologies. We have recently described algorithms that simultaneously optimize proteins for both reduced T cell epitope content and high-level function. In silico analysis of this dual objective design space reveals that there is no single global optimum with respect to protein deimmunization. Instead, mutagenic epitope deletion yields a spectrum of designs that exhibit tradeoffs between immunogenic potential and molecular function. The leading edge of this design space is the Pareto frontier, i.e. the undominated variants for which no other single design exhibits better performance in both criteria. Here, the Pareto frontier of a therapeutic enzyme has been designed, constructed, and evaluated experimentally. Various measures of protein performance were found to map a functional sequence space that correlated well with computational predictions. These results represent the first systematic and rigorous assessment of the functional penalty that must be paid for pursuing progressively more deimmunized biotherapeutic candidates. Given this capacity to rapidly assess and design for tradeoffs between protein immunogenicity and functionality, these algorithms may prove useful in augmenting, accelerating, and de-risking experimental deimmunization efforts

Measurement of the cross-section ratio 3H(d,γ)5He/3H(d,α)n at 100 keV

The cross-section ratio for 3H(d,γ)5He relative to 3H(d,α)n has been measured at an effective deuteron bombarding energy of 100 keV with a NaI pair spectrometer and a tritiated-titanium target. The ratio was determined to be (1.2±0.3)×10^-4 by comparing the spectra and count rates for 3H(d,γ)5He and 3H(d,α)n with 2H(3He,γ)5Li and 2H(3He,α)1H