The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse

Numerous studies have investigated how bulk lipid metabolism is influenced in obesity and in particular how the composition of triglycerides found in the cytosol change with increased adipocyte expansion. However, in part reflecting the analytical challenge the composition of cell membranes, and in particular glycerophospholipids, an important membrane component, have been seldom investigated. Cell membrane components contribute to a variety of cellular processes including maintaining organelle functionality, providing an optimized environment for numerous proteins and providing important pools for metabolites, such as choline for one-carbon metabolism and S-adenosylmethionine for DNA methylation. Here, I have conducted a comprehensive lipidomic and transcriptomic study of white adipose tissue in mice that become obese either through genetic modification (ob/ob genotype), diet (high-fat diet) or a combination of the two across the life course. Specifically, I demonstrated that the changes in triglyceride metabolism that dominate the overall lipid composition of white adipose tissue were distinct from the compositional changes of glycerophospholipids. These latter lipids became more unsaturated to maintain the fluidity and normal function of the membrane in the initiation of obesity but then turned saturated after long-term administration of HFD and aging. This suggests that while triglycerides within the adipose tissue may be a relatively inert store of lipids, the compositional changes occur in cell membranes with more far-reaching functional consequences in both obesity and aging. The two-phase change of phospholipids can be correlated well with transcriptional and one-carbon metabolic changes within the adipocytes. The transcriptomic study demonstrated that the lipid metabolic pathways regulated by the peroxisome, AMPK, insulin and PPARγ signaling were activated in the initiation of obesity but inhibited in the adipose tissue of old ob/ob mice along with up-regulated inflammation pathways. The brown and white adipose tissue of PPARα-knock-out mice were also studied by lipidomic tools to get a deeper understanding of the effect of the peroxisome and PPAR system on adipose tissue and lipid metabolism during obesity. Most of the lipids were increased and became more saturated and shorter in adipose tissues of PPARα null mice, which is in good accordance with the results of the former animal study. In conclusion, my work using different rodent models and multi-omics techniques demonstrated a protective metabolic mechanism activated in the initiation but impaired at the end of the processes of obesity and aging, which could be an explanation of the similarity of obesity and aging in terms of high incidence of the metabolic syndrome and related diseases

Domain wall brane in a reduced Born-Infeld-f(T)f(T) theory

The Born-Infeld $f(T)$ theory is reduced from the Born-Infeld determinantal gravity in Weitzenb\"ock spacetime. We investigate a braneworld scenario in this theory and obtain an analytic domain wall solution by utilizing the first-order formalism. The model is stable against the linear tensor perturbation. It is shown that the massless graviton is localized on the brane, but the continuous massive gravitons are non-localized and will generate a tiny correction with the behavior of ${1}/{(k r)^{3}}$ to the Newtonian potential. The four-dimensional teleparallel gravity is recovered as an effective infrared theory on the brane. As a physical application, we consider the (quasi-)localization property of spin-1/2 Dirac fermion in this model.Comment: 9 pages, 2 figures, published versio

Mode of anesthesia for cesarean delivery with pernicious placenta previa — a retrospective study

Objectives: Anesthesia for cesarean delivery in parturients diagnosed with pernicious placenta previa remains controversial. This study aimed to review pernicious placenta previa cases to evaluate anesthetic management strategies. Material and methods: This retrospective analysis included patients who underwent cesarean delivery (CD) for pernicious placenta previa at the Affiliated Hospital of Zunyi Medical University between December 1, 2012 and November 31, 2017. Patient demographic data, obstetric characteristics, anesthetic management, and maternal outcomes were extracted from the hospital’s computerized database. Results: In all, 61 consecutive cases of pernicious placenta previa were identified among 9512 cesarean deliveries. General anesthesia was performed on 27 of the 61 patients (44.3%). Among GA group, 16 (59.3%) had placenta accreta, 8 of whom required cesarean hysterectomy. Also, 13 of the 27 (48.1%) GA patients required transfer to the intensive care unit. The other 34 patients (55.7%) were given regional anesthesia, 9 of whom were converted to general anesthesia due to excessive bleeding and prolonged operation times. Statistical results indicated that regional anesthesia was associated with a significantly shorter operation time, less perioperative blood loss, fewer intraoperative red blood cell transfusions, and a lower incidence of complications. Conclusions: Anesthetic management is important for parturients with pernicious placenta previa. Although regional anesthesia was our preferred method for these patients, general anesthesia is safe for patients with pernicious placenta previa who experience massive blood loss and prolonged operation times

Ethyl 6-amino-5-cyano-2-methyl-4-propyl-4H-pyran-3-carboxyl­ate

The pyran ring of the title compound, C13H18N2O3, is almost planar (r.m.s. deviation = 0.059 Å). The crystal packing is stabilized by N—H⋯O and N—H⋯N hydrogen bonds

Varying magnetism in the lattice distorted Y2NiIrO6 and La2NiIrO6

We investigate the electronic and magnetic properties of the newly synthesized double perovskites Y$_{2}$NiIrO$_{6}$ and La$_{2}$NiIrO$_{6}$, using density functional calculations, crystal field theory, superexchange pictures, and Monte Carlo simulations. We find that both systems are antiferromagnetic (AFM) Mott insulators, with the high-spin Ni$^{2+}$ $t_{2g}$$^{6}e_{g}$$^{2}$ ($S=1$) and the low-spin Ir$^{4+}$ $t_{2g}$$^{5}$ ($S=1/2$) configurations. We address that their lattice distortion induces $t_{2g}$-$e_{g}$ orbital mixing and thus enables the normal Ni$^{+}$-Ir$^{5+}$ charge excitation with the electron hopping from the Ir `$t_{2g}$' to Ni `$e_g$' orbitals, which promotes the AFM Ni$^{2+}$-Ir$^{4+}$ coupling. Therefore, the increasing $t_{2g}$-$e_{g}$ mixing accounts for the enhanced $T_{\rm N}$ from the less distorted La$_{2}$NiIrO$_{6}$ to the more distorted Y$_{2}$NiIrO$_{6}$. Moreover, our test calculations find that in the otherwise ideally cubic Y$_{2}$NiIrO$_{6}$, the Ni$^{+}$-Ir$^{5+}$ charge excitation is forbidden, and only the abnormal Ni$^{3+}$-Ir$^{3+}$ excitation gives a weakly ferromagnetic (FM) behavior. Furthermore, we find that owing to the crystal field splitting, Hund exchange, and broad band formation in the highly coordinated fcc sublattice, Ir$^{4+}$ ions are not in the $j_{\rm eff}=1/2$ state but in the $S=1/2$ state carrying a finite orbital moment by spin-orbit coupling (SOC). This work clarifies the varying magnetism in Y$_{2}$NiIrO$_{6}$ and La$_{2}$NiIrO$_{6}$ associated with the lattice distortions.Comment: 7 pages, 7 figures, 1 tabl