13 research outputs found

    Business plan

    Full text link
    1. Business project - function, choice of legal form, founding budget. 2. Setting up own business - subject information, marketing, financial information, hazards of projec

    Business plan

    Full text link
    1. Podnikatelský plán, podnikatelský záměr - funkce podnikatelského plánu, volba právní formy, zakladatelský rozpočet, zdroje financování podnikatelské činnosti 2. Vlastní podnikatelský záměr - věcná stránka, marketing, finanční stránka, rizika projektu1. Business project - function, choice of legal form, founding budget. 2. Setting up own business - subject information, marketing, financial information, hazards of projec

    Governors of the Chrudim Region in the years 1650-1750 (1751), their property background and construction activities

    Full text link
    Bakalářská práce se zabývá majetkovou základnou a podobou sídel deseti hejtmanů Chrudimského kraje za panský stav v letech 1650-1750 (1751). Práce porovnává rezidenční objekty a sleduje, zda jmenování do funkce krajského hejtmana a s tím spojená existence sídla krajského hejtmana mohla mít vliv na stavební podobu rezidenčního sídla, jeho zvelebení či rozšíření nebo jej přímo motivovala k výstavbě či zakoupení nového sídla blíže ke krajskému městu Chrudim. Případně zda se za funkcí do Chrudimského kraje přistěhovali.The barchelor thesis deals with the property base and the form of the residensis of ten governors of the Chrudim region under the lordly state in the years 1650-1750 (1751). The thesis compares the residential buildings and investigates whether the appoitment to the office of the regional governor and the associated existence of the regional governor´s residence could have influenced the building form of the residence, its improvement or extension, or directly motivated him to build or purchase a new residence closer to the regional town of Chrudim. Alternatively, whether they moved to the Chrudim region to take up the post.Fakulta filozofickápředstavení práce - téma hejtmanů nezpracováno, cíl popsat sídlo hejtmanů postup - rozshal - období po konci 30leté války, omezeno na pánský stav - lepší prameny Přečtení posudků - vedoucí B. Šeda - klasifikace B-C (navrhováno) oponnet P. Vorel - klasifikace E /navrhuje) Rozprava - věcná reakce na posudek oponenta Debata o časovém a obsahovém vymezení tématu práce.Dokončená práce s úspěšnou obhajobo

    Project management with the specifics of tourism

    Full text link
    The thesis focuses on issues of project management and the project life cycle in tourism. It answers the question what specifics are reflected in projects financed by the European Union in the tourism sector. The thesis evaluated the benefits of selected projects financed by EU funds for the development of tourism and the development of the Czech Republic through the tourism sector

    Employee training and development in the organization

    Get PDF
    Tato bakalářská práce se zabývá Vzděláváním a rozvojem pracovníků v organizaci. Cílem práce bylo teoreticky popsat oblasti, které se tohoto tématu týkají, a následně je ověřit v praxi neziskové organizace Diakonie Západ. V praktické části bylo provedeno dotazníkové šetření mezi zaměstnanci jmenované organizace. Výsledky šetření prokázaly, že Diakonie Západ se vzdělávání a rozvoji svých zaměstnanců věnuje cílevědomě a klade na ně velký důraz. V závěrečné části práce je formulované konkrétní doporučení, které bylo předáno také vedení Diakonie Západ s cílem tuto oblast ještě vylepšit.ObhájenoThe bachelor thesis focused on Employee training and development in the organization. The objective of this bachelor thesis was to describe the areas related to this topic in a theoretical way and verify them in practice in Diakonie Západ. In the practical part, a questionnaire survey was conducted among the company's employees. The results show that Diakonie Západ devotes to education and growth of their employees purposefully and put emphasis on them. In conclusion, of this bachelor thesis there is the specific recommendation which was handed to Diakonie Západ with the purpose of improvement in that area

    Business plan

    Get PDF
    1. Business project - function, choice of legal form, founding budget. 2. Setting up own business - subject information, marketing, financial information, hazards of projec

    Occurrence of Two 5-Aminolevulinate Biosynthetic Pathways in Streptomyces nodosus subsp. asukaensis Is Linked with the Production of Asukamycin

    Full text link
    We report the results of cloning genes for two key biosynthetic enzymes of different 5-aminolevulinic acid (ALA) biosynthetic routes from Streptomyces. The genes encode the glutamyl-tRNA(Glu) reductase (GluTR) of the C(5) pathway and the ALA synthase (ALAS) of the Shemin pathway. While Streptomyces coelicolor A3(2) synthesizes ALA via the C(5) route, both pathways are operational in Streptomyces nodosus subsp. asukaensis, a producer of asukamycin. In this strain, the C(5) route produces ALA for tetrapyrrole biosynthesis; the ALA formed by the Shemin pathway serves as a precursor of the 2-amino-3-hydroxycyclopent-2-enone moiety (C(5)N unit), an antibiotic component. The growth of S. nodosus and S. coelicolor strains deficient in the GluTR genes (gtr) is strictly dependent on ALA or heme supplementation, whereas the defect in the ALAS-encoding gene (hemA-asuA) abolishes the asukamycin production in S. nodosus. The recombinant hemA-asuA gene was expressed in Escherichia coli and in Streptomyces, and the encoded enzyme activity was demonstrated both in vivo and in vitro. The hemA-asuA gene is situated within a putative cluster of asukamycin biosynthetic genes. This is the first report about the cloning of genes for two different ALA biosynthetic routes from a single bacterium

    Polyenic Antibiotics and Other Antifungal Compounds Produced by Hemolytic <i>Streptomyces</i> Species

    Full text link
    Streptomyces are of great interest in the pharmaceutical industry as they produce a plethora of secondary metabolites that act as antibacterial and antifungal agents. They may thrive on their own in the soil, or associate with other organisms, such as plants or invertebrates. Some soil-derived strains exhibit hemolytic properties when cultivated on blood agar, raising the question of whether hemolysis could be a virulence factor of the bacteria. In this work we examined hemolytic compound production in 23 β-hemolytic Streptomyces isolates; of these 12 were soil-derived, 10 were arthropod-associated, and 1 was plant-associated. An additional human-associated S. sp. TR1341 served as a control. Mass spectrometry analysis suggested synthesis of polyene molecules responsible for the hemolysis: candicidins, filipins, strevertene A, tetrafungin, and tetrin A, as well as four novel polyene compounds (denoted here as polyene A, B, C, and D) in individual liquid cultures or paired co-cultures. The non-polyene antifungal compounds actiphenol and surugamide A were also identified. The findings indicate that the ability of Streptomyces to produce cytolytic compounds (here manifested by hemolysis on blood agar) is an intrinsic feature of the bacteria in the soil environment and could even serve as a virulence factor when colonizing available host organisms. Additionally, a literature review of polyenes and non-polyene hemolytic metabolites produced by Streptomyces is presented
    corecore