Ice Scours in the Sediments of Glacial Lake Iroquois, Prince Edward County, Eastern Ontario

Straight or slightly curved ice scours are found in thin glacilacustrine sediment of eastern Lake Iroquois, especially near the crest of an escarpment in Prince Edward County. They are large (to 3.57 km long and 174 m wide), shallow (about 1 m deep) and oriented in a nearly westerly direction. Irregular ridges of sediment have been pushed up along the sides and at the western end of some scours. Bedrock is near the ground surface, but had little influence on the formation of the scours. Based on their shape, location and pattern, we conclude that the scours were most likely formed in shallow water of the short-lived Sydney phase of Lake Iroquois by lake ice driven by prevailing northeasterly winds from the retreating Laurentide Ice Sheet.On trouve des sillons glaciels, rectilignes ou courbes, dans des sédiments lacustres de l'est du Lac Iroquois, en particulier près du sommet d'un escarpement dans le comté de Prince Edward. Ces sillons sont larges (jusqu'à 3,57 km de longueur et 174 m de largeur), peu profonds (environ 1 m) et orientés vers l'ouest. Des bourrelets irréguliers de sédiments apparaissent en bordure et à l'extrémité ouest de quelques dépressions. Le substratrum affleure presque, mais a eu peu d'influence sur la formation des sillons. En se fondant sur leur forme, leur emplacement et leur agencement, on en conclut que les sillons ont été formés dans les eaux peu profondes du Lac Iroquois au cours de la courte phase de Sydney, par les glaces du lac poussées par les vents dominants du nord-est, en provenance de l'Inlandsis laurentidien alors en retrait.,1EZlOBbIE B0P03Zlbl B HAHOCAX 3AMEP3lilErO HP0KE3CK0r0 03EPA. TPAOCTBO nPMHU 3ZtBAPZl. BOCTOMHbM OHTAPHO. B TOHKHX JieaOBblX HaHOCaX B BOCTOi-lHOH HacTH Hpok-e3Ckoro 03epa ocoôeHHO pa/ioM c rpefiHeM KpyToro ck'JioHa rpa(|)CTBa flpnnu dnsapn MOAHO na6^ioziaTb npSMbie tum cnerka HSBHBaiolilnecn .neaoBbie 6opo3AU. OHM HMeioT fkyibunie pa3Mepw (no 3.57 KM B JWHHy H 174 M B mnpnHyi. MCAKM H opueH TnpoBanbi npenMylilecTBeHHO Ha 3anaa. HepeperyjiapHbie rpefJHH HaHocoB HaxoflflT-CJi no fjoKaM H B 3anaziHbix OKOHLiaHiiax HeKOTopwx 6opo3/j. HecMOTpa Ha TO. MTO nopo/ia HaxoziHTCfi 6^H3KO OT noBepxHocTH rpyHTa. eë B^nflnne Ha (|K>pMnpoBaHHe mix 6opo34 HeBCiHKO. Ha ocHOBaHiin (tjopMbl, pacnano*eHHfl H piicyHKa 5opo3/t /icnaeTC" BUBO/1, MTO OHH. CKOpee BCerO. f)W/lH ClpOpMHpOBaHbl B MeJIKHX BOZiaX MpOKe3CKOrO 03epa BO BpeMfl KopoTkOH (ba3bi Cn/iHeiï nozi B03,aeHCTBi(eM 03ëpnoro j\t>j\a, HaitccetiHoro /lOMHHHpyiOlilHMH CeBepOBOCTOMHhlMH BeTpaMH OT OTcTynaioUJero /laBpenTHitcKoro MaTepnKOBoro neaHHKa

APX001 Is Effective in the Treatment of Murine Invasive Pulmonary Aspergillosis.

Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are needed. The novel antifungal APX001A targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of APX001A against A. fumigatus and the in vivo activity of its prodrug APX001 in an immunosuppressed mouse model of IPA. APX001A inhibited the growth of A. fumigatus with a minimum effective concentration of 0.03 μg/ml. The use of 50 mg/kg 1-aminobenzotriazole (ABT), a suicide inhibitor of cytochrome P450 enzymes, enhanced APX001A exposures (area under the time-concentration curve [AUC]) 16- to 18-fold and enhanced serum half-life from ∼1 to 9 h, more closely mimicking human pharmacokinetics. We evaluated the efficacy of APX001 (with ABT) in treating murine IPA compared to posaconazole treatment. Treatment of mice with 78 mg/kg once daily (QD), 78 mg/kg twice daily, or 104 mg/kg QD APX001 significantly enhanced the median survival time and prolonged day 21 postinfection overall survival compared to the placebo. Furthermore, administration of APX001 resulted in a significant reduction in lung fungal burden (4.2 to 7.6 log10 conidial equivalents/g of tissue) versus the untreated control and resolved the infection, as judged by histopathological examination. The observed survival and tissue clearance were comparable to a clinically relevant posaconazole dose. These results warrant the continued development of APX001 as a broad-spectrum, first-in-class treatment of invasive fungal infections

Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis.

There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to Fusarium and Scedosporium Manogepix (MGX; APX001A) is a novel antifungal that targets the conserved Gwt1 enzyme required for localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi. We evaluated the in vitro activity of MGX and the efficacy of the prodrug fosmanogepix (APX001) in immunosuppressed murine models of hematogenously disseminated fusariosis and pulmonary scedosporiosis. The MGX minimum effective concentration (MEC) for Scedosporium isolates was 0.03 μg/ml and ranged from 0.015 to 0.03 μg/ml for Fusarium isolates. In the scedosporiosis model, treatment of mice with 78 mg/kg and 104 mg/kg of body weight fosmanogepix, along with 1-aminobenzotriazole (ABT) to enhance the serum half-life of MGX, significantly increased median survival time versus placebo from 7 days to 13 and 11 days, respectively. Furthermore, administration of 104 mg/kg fosmanogepix resulted in an ∼2-log10 reduction in lung, kidney, or brain conidial equivalents/gram tissue (CE). Similarly, in the fusariosis model, 78 mg/kg and 104 mg/kg fosmanogepix plus ABT enhanced median survival time from 7 days to 12 and 10 days, respectively. A 2- to 3-log10 reduction in kidney and brain CE was observed. In both models, reduction in tissue fungal burden was corroborated with histopathological data, with target organs showing reduced or no abscesses in fosmanogepix-treated mice. Survival and tissue clearance were comparable to a clinically relevant high dose of liposomal amphotericin B (10 to 15 mg/kg). Our data support the continued development of fosmanogepix as a first-in-class treatment for infections caused by these rare molds

The Use of a Non-Point Source Pollution Self-Assessment for Greenhouse and Nursery Operators in California

Water quality rules adopted in 2001 in San Diego, California, created new requirements for greenhouse and plant nursery growers to manage surface run-off that could potentially affect drinking water, recreational locations, and wildlife habitat. A Run-off and Non-Point Source Pollution Self-Assessment for Greenhouse and Container Nurseries was developed as a series of worksheets that translated technical information for growers to meet legal requirements, maintain their property value, and enhance the quality of their environment. Self-assessment results determined a need for additional training on run-off management and prevention pollution through more site-specific fertilization and pest management techniques based on routine monitoring