271 research outputs found
Ultra-Sensitive Hot-Electron Nanobolometers for Terahertz Astrophysics
The background-limited spectral imaging of the early Universe requires
spaceborne terahertz (THz) detectors with the sensitivity 2-3 orders of
magnitude better than that of the state-of-the-art bolometers. To realize this
sensitivity without sacrificing operating speed, novel detector designs should
combine an ultrasmall heat capacity of a sensor with its unique thermal
isolation. Quantum effects in thermal transport at nanoscale put strong
limitations on the further improvement of traditional membrane-supported
bolometers. Here we demonstrate an innovative approach by developing
superconducting hot-electron nanobolometers in which the electrons are cooled
only due to a weak electron-phonon interaction. At T<0.1K, the electron-phonon
thermal conductance in these nanodevices becomes less than one percent of the
quantum of thermal conductance. The hot-electron nanobolometers, sufficiently
sensitive for registering single THz photons, are very promising for
submillimeter astronomy and other applications based on quantum calorimetry and
photon counting.Comment: 19 pages, 3 color figure
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a community-based sample. We report on 5 longevity and aging traits in up to 1345 Framingham Study participants from 330 families. Multivariable-adjusted residuals were computed using appropriate models (Cox proportional hazards, logistic, or linear regression) and the residuals from these models were used to test for association with qualifying SNPs (70, 987 autosomal SNPs with genotypic call rate [greater than or equal to]80%, minor allele frequency [greater than or equal to]10%, Hardy-Weinberg test p [greater than or equal to] 0.001).RESULTS:In family-based association test (FBAT) models, 8 SNPs in two regions approximately 500 kb apart on chromosome 1 (physical positions 73,091,610 and 73, 527,652) were associated with age at death (p-value < 10-5). The two sets of SNPs were in high linkage disequilibrium (minimum r2 = 0.58). The top 30 SNPs for generalized estimating equation (GEE) tests of association with age at death included rs10507486 (p = 0.0001) and rs4943794 (p = 0.0002), SNPs intronic to FOXO1A, a gene implicated in lifespan extension in animal models. FBAT models identified 7 SNPs and GEE models identified 9 SNPs associated with both age at death and morbidity-free survival at age 65 including rs2374983 near PON1.
In the analysis of selected candidate genes, SNP associations (FBAT or GEE p-value < 0.01) were identified for age at death in or near the following genes: FOXO1A, GAPDH, KL, LEPR, PON1, PSEN1, SOD2, and WRN. Top ranked SNP associations in the GEE model for age at natural menopause included rs6910534 (p = 0.00003) near FOXO3a and rs3751591 (p = 0.00006) in CYP19A1. Results of all longevity phenotype-genotype associations for all autosomal SNPs are web posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007. CONCLUSION: Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging
Wave Function of a Brane-like Universe
Within the mini-superspace model, brane-like cosmology means performing the
variation with respect to the embedding (Minkowski) time before fixing
the cosmic (Einstein) time . The departure from Einstein limit is
parameterized by the 'energy' conjugate to , and characterized by a
classically disconnected Embryonic epoch. In contrast with canonical quantum
gravity, the wave-function of the brane-like Universe is (i) -dependent,
and (ii) vanishes at the Big Bang. Hartle-Hawking and Linde proposals dictate
discrete 'energy' levels, whereas Vilenkin proposal resembles -particle
disintegration.Comment: Revtex, 4 twocolumn pages, 3 eps figures (accepted for publication in
Class. Quan. Grav.
Genetics of Bone and Muscle Interactions in Humans
Purpose of Review To summarize the evidence from recent studies on the shared genetics between bone and muscle in humans.
Recent Findings Genome-wide association studies (GWAS) have successfully identified a multitude of loci influencing the
variability of different bone or muscle parameters, with multiple loci overlapping between the traits. In addition, joint analyses
of multiple correlated musculoskeletal traits (i.e., multivariate GWAS) have underscored several genes with possible pleiotropic
effects on both bone and muscle including MEF2C and SREBF1. Notably, several of the proposed pleiotropic genes have been
validated using human cells or animal models.
Summary It is clear that the study of pleiotropy may provide novel insights into disease pathophysiology potentially leading to
the identification of new treatment strategies that simultaneously prevent or treat both osteoporosis and sarcopenia. However, the
role of muscle factors (myokines) that stimulate bone metabolism, as well as osteokines that affect muscles, is in its earliest stage
of understandin
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