Multiple Lives of The Products: An Investigation Of Products’ Journey in Freecycle Community

In today's needs, it is not enough to imagine products who have only one owner in their entire lives. To create more sustainable futures, designers might increase their ability to imagine multiple lives for things. To enable it, scale is the matter of concern. By increasing the usage scale, and examining the exchange of second-hand products informs designers by imagining multiple scenarios related to things lifes. In this paper we focus on local freecycle groups on Facebook in the context of the second-hand product’s circulation. In the field research, we identify significant usage cases of second-hand products that have multiple owners. We classify them under four sections, which are student house, permanent house, families with a baby, and repurposers according to their concerns, criteria and behaviors related to handed-over products. Finally, we present insights about users’ expectations and concerns that has decisive role in determining the life cycle of the product. We propose thinking for larger usage scales through examples that we provide, guide designers and companies in terms of products' journeys in circulation

SEED STRUCTURE AND EMBRYO DEVELOPMENT OF SESELI RESINOSUM (APIACEAE)

The male and female gametophyte development in Seseli resinosum Freyn et Sint were studied with a-light microscope. In order to study the embryology of Seseli resinosum Freyn & Synth that an endemic plant spreading in Zonguldak-Bartin region development of the seed and embryo have been examined. Embryo development of Seseli resinosum was solanad type. In the sections taken zygote, proembryo, 4-cell embryo, 8-cell embryo, spherical embryo, heart-shaped embryo stages were observed. There are differences in the participation of the integument in the formation of the testa. In Apiaceae, only the epidermis of the outer integument forms the seed coat. Since the fruit type is a schizocarp, the testa and the pericarp are inseparable. Testa was seen as 3 or 6 layers. The layers consist of thin-walled cells. The outermost layer is single row and its thickness is less than the other layers

Teachers and school administrators’ perceptions of characteristics of an effective school: A study of Anatolian high schools (exam-based entrance high schools) in Turkey

The aim of the research reported on here was to determine the perceptions of school administrators and teachers working at Anatolian high schools on the characteristics of effective schools. The determined perceptions of teachers and administrators were important for creating more efficient educational domains by sharing leadership among stakeholders in education management. We used the Relational Survey Model to study a group composed of teachers and school administrators working at Anatolian high schools in the Ankara province of Turkey. The sample for this research consisted of 300 teachers selected through proper sampling from within the population. Data obtained from participants using the Effective School Scale were tested by t-test and one-way ANOVA. A significant difference was found between the views of school administrators and teachers regarding the effectiveness of Anatolian high schools in the Ankara province. This study found that the school administrators deemed the Anatolian high schools of Ankara to be a lot more effective than the teachers thought they were. As a conclusion, suggestions for increasing the effectiveness of schools are presented

Coexistence of three malignancies: Two different lung cancers synchronous with lymphoma

Epithelial tumors synchronous with hematologic malignancies are very rare. The hystopathologic type and stage of synchronous tumors are very important for prognosis. A 77-year-old male patient was diagnosed with lymphoma after an excisional biopsy was taken from the retroauricular region. Positron emission tomography, performed for lymphoma staging, revealed a positive solid nodule (SUVmax: 24.3) in the posterobasal segment of the right lower lobe and a negative subsolid nodule in the anterior segment of the upper lobe. Right lower lobectomy and wedge resection for subsolide nodule in the upper lobe were performed. Histopathological examination revealed mildly differentiated squamous cell carcinoma for the solid nodule and mildly differentiated adenocarcinoma with lepidic pattern for the subsolid nodule. The patient was treated for only lymphoma according to the decision of the tumor board, and his condition is stable for 1 year without any evidence of lung cancer recurrence. This case presents the treatment approach and the fact that triple synchronic malignant cases are rare in the literature

The role of hepcidin and its related genes (BMP6, GDF-15, and HJV) in rats exposed to ischemia and reperfusion

Background/aim: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), and hemojuvelin (HJV)] were also measured by RT-PCR technique. In addition, the tissues were evaluated histopathologically. Results: No significant association was found between renal dysfunction and I/R when compared to biochemical parameters (P > 0.05). However, differences in platelet values were statistically significant (P < 0.05). Expression levels of GDF-15, BMP6, and HJV genes increased, but this increase was not statistically significant. In addition, histopathological evaluation was performed using hematoxylin and eosin stain. This showed a significant relationship between the control group and I/R group for ischemic and nonischemic kidney scoring. Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R.Background/aim: To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. Materials and methods: A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats and then the I/R-treated kidneys were removed. The levels of serum biochemical markers were evaluated after renal I/R. The expression levels of hepcidin-linked genes [growth differentiation factor 15 (GDF-15), bone morphogenetic protein 6 (BMP6), and hemojuvelin (HJV)] were also measured by RT-PCR technique. In addition, the tissues were evaluated histopathologically. Results: No significant association was found between renal dysfunction and I/R when compared to biochemical parameters (P > 0.05). However, differences in platelet values were statistically significant (P < 0.05). Expression levels of GDF-15, BMP6, and HJV genes increased, but this increase was not statistically significant. In addition, histopathological evaluation was performed using hematoxylin and eosin stain. This showed a significant relationship between the control group and I/R group for ischemic and nonischemic kidney scoring. Conclusion: Hepcidin and BMP6, HJV, and GDF-15 should be taken into account when investigating the process of I/R

Welcome to the December 2023 Issue (Vol:29, No:4) and Current News of the European Journal of Therapeutics

Dear Colleagues, In this editorial, we would like to share with you important developments in the European Journal of Therapeutics (Eur J Ther). First of all, as the editorial team, we would like you to know that we hold frequent meetings to benefit our esteemed colleagues and continue to work with great devotion in line with our goal of taking the journal further. We have previously shared with you that we have applied to many indexes. It is with great pleasure that we would like to inform you that in the last few months, more of our index applications have been approved. Index Copernicus, as a result of this application, the ICV 2022 value of our journal was determined to be 100 (approved 2023-10-31) [1] BASE (Bielefeld Academic Search Engine) (approved 2023-11-30) [2] Sherpa Romeo (approved 2023-09-27) [3] MIAR (approved 2023-10-16) [4] All indexes in our journal are currently included on the journal web page [5]. As the editorial team, we would like to inform you that we have determined a policy on this issue for our journal [6], taking into account the recommendations of important international ethics committees such as the Committee on Publication Ethics (COPE) [7] and the World Association of Medical Editors (WAME) [8], which have recently become a trendy topic of discussion about AI chatbots and academic studies prepared with the support of such tools. As you know, when our journal was founded in 1990 [9], it was published in two yearly issues. It is an essential responsibility for us to carry our journal, which continued its publication life with three issues a year in 2009 [10] and four issues a year in 2014 [11]. With your valuable support, we would like to announce that we will increase our journal to 6 issues a year as of 2024 (February, April, June, August, October and December) with the rapidly growing progress of our journal. Unfortunately, we cannot share the names of the referees who made significant contributions to our journal in 2023 due to the changes in the article submission interface during the year and the inaccessibility of some data in the previous interface. However, we would like to emphasize again that we are grateful to all of them for their valuable contributions. Moreover, to expand our journal's referee list, we would like to remind you that competent academics who volunteer in this regard can fill out the “Become a Reviewer for the European Journal of Therapeutics” form [12]. Finally, we would like to point out that we have strengthened our editorial team with an academician competent in dentistry, Fatih Sari, DDS, PhD. Fatih Sari, DDS, PhD, is a new Editorial Board Member of the Eur J Ther. Dr. Sari is an Associate Professor in the Department of Prosthodontics at the Gaziantep University Faculty of Dentistry. He is a Vice Dean of the Faculty of Dentistry and Head of Clinical Departments. Dr. Sari is a prosthodontist and a member of the Turkish Dental Association. He has experience in implant-supported fixed prostheses, Cad/Cam applications and dental materials. We look forward to being able to offer you a large number of high-quality and valuable articles over the coming year. In addition, we would like to thank the readers, authors and reviewers of the Eur J Ther for their continuous support. Sincerely yours

Cardiometabolic risk factors in pediatric kidney transplant recipients

Objective: There is an increased risk of obesity and metabolic syndrome among kidney transplant recipients, which adversely affects cardiovascular and renal outcomes in these patients. The present study aims to investigate the prevalence of metabolic syndrome in pediatric kidney transplant recipients and the associations of metabolic syndrome with cardiovascular disease and graft function. Materials and Methods: This cross-sectional, single-center study included 52 kidney transplant recipients (27 males) transplanted before 18 years of age. All subjects underwent a comprehensive assessment that included anthropometric and blood pressure measurements and laboratory tests. Metabolic syndrome was defined based on the recent recommendations of the Pediatric Renal Nutrition Taskforce. Left ventricular hypertrophy was assessed as a risk factor for cardiovascular disease, and estimated glomerular filtration rate was assessed to determine graft function. Results: The median age of patients was 15.9 (13.8;18.4) years, and the median follow-up time was 35.5 (20.0;62;0) months after transplantation. Nineteen patients (36.5%) were obese or overweight, 43 (83%) had hypertension or controlled hypertension, 23 (44%) had dyslipidemia, and 9 (17%) had hyperglycemia. Ten patients (19.2%) were diagnosed with metabolic syndrome. Twenty-eight patients (54%) had left ventricular hypertrophy. The prevalence of left ventricular hypertrophy was higher in patients with metabolic syndrome than in those without metabolic syndrome (90% vs. 45%, P =.014), whereas estimated glomerular filtration rate did not differ between the 2 groups. Conclusion: Cardiometabolic risk factors are common in pediatric kidney transplant recipients. Approximately one-fifth of patients have metabolic syndrome, and left ventricular hypertrophy is much more common among patients with metabolic syndrome. However, there is no relationship between metabolic syndrome and graft dysfunction

Production of Bovine Colostrum for Human Consumption to Improve Health

Colostrum contains all essential nutrients for the neonate during the first days of life, with impacts that continue far beyond these first days. Bovine colostrum has been used for human consumption due to the high concentrations of bioactive proteins, vitamins, minerals, growth factors, as well as free and conjugated oligosaccharides. Processes involved in the preparation of bovine colostrum for human consumption play a pivotal role in preserving and maintaining the activity of the bioactive molecules. As bovine colostrum is a multifunctional food that offers a myriad of benefits for human health, assessing the main processes used in preparing it with both advantages and disadvantages is a crucial point to discuss. We discuss major processes effects for colostrum production on the nutritional value, some advanced technologies to preserve processed bovine colostrum and the endproduct forms consumed by humans whether as dairy products or dietary supplements

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

The Ottoman Court On The Road: Royal Mobility And The Imperial Residences Between Edirne And Istanbul, 1657-1703

This dissertation, while focusing on the itinerant character and rule of the court of Mehmed IV on the one hand, takes as its subject matter the Ottoman palaces, gardens, estates and pavilions that were built, renovated and/or repaired and used around Edirne and particularly between Edirne and Istanbul between 1657 and 1703. It introduces to scholarship, through the use of a vast body of primarily expenserelated archival documents, a number of such royal residences for the first time. While doing this, rather than focusing on the formal and architectural natures of these edifices, it contextualizes them through the perspective of early modern court studies. Known as “the hunter” in classical Turkish historiography, Sultan Mehmed IV is acclaimed for his mobility foremost for this reason, while this mobility manifests itself most clearly in the court’s relocation to Edirne in the second half of the seventeenth century. This study acknowledges itinerancy as an essential characteristic of the Ottoman court in a comparable manner to their contemporary European, Safavid and Mughal courts, and analyses the royal residences it is concerned with in this context. It argues that, beyond simply being hunting lodges, the royal residences in question were built as a result of the court’s needs –foremost of which was that of accommodation while on the road– and thus were a direct and organic outcome of the court’s peripatetic lifestyle. On the other hand, analysis of the court’s itinerancy at this period also uncovers underlying patterns of mobility that hinge on the year 1676, before and after which the court’s movements display differing trajectories. Finally, the dissertation demonstrates further that the construction activities around Edirne at this time display a strong geographical and temporal parallel with the court’s mobility patterns between the two cities, thus underscoring the close relationship between the two phenomena