Smart Load-Based Resource Optimization Model to Enhance the Performance of Device-to-Device Communication in 5G-WPAN

In wireless personal area networks (WPANs), devices can communicate with each other without relying on a central router or access point. They can improve performance and efficiency by allowing devices to share resources directly; however, managing resource allocation and optimizing communication between devices can be challenging. This paper proposes an intelligent load-based resource optimization model to enhance the performance of device-to-device communication in 5G-WPAN. Intelligent load-based resource optimization in device-to-device communication is a strategy used to maximize the efficiency and effectiveness of resource usage in device-to-device (D2D) communications. This optimization strategy is based on optimizing the network’s resource load by managing resource utilization and ensuring that the network is not overloaded. It is achieved by monitoring the current load on the network and then adjusting the usage of resources, such as bandwidth and power, to optimize the overall performance. This type of optimization is essential in D2D communication since it can help reduce costs and improve the system’s performance. The proposed model has achieved 86.00% network efficiency, 93.74% throughput, 91.94% reduced latency, and 92.85% scalability

Resistance Profiles to Second-Line Anti-Tuberculosis Drugs and Their Treatment Outcomes: A Three-Year Retrospective Analysis from South India

Background: Patients with first-line drug resistance (DR) to rifampicin (RIF) or isoniazid (INH) as a first-line (FL) line probe assay (LPA) were subjected to genotypic DST using second-line (SL) LPA to identify SL-DR (including pre-XDR) under the National TB Elimination Program (NTEP), India. SL-DR patients were initiated on different DR-TB treatment regimens and monitored for their outcomes. The objective of this retrospective analysis was to understand the mutation profile and treatment outcomes of SL-DR patients. Materials and Methods: A retrospective analysis of mutation profile, treatment regimen, and treatment outcome was performed for SL-DR patients who were tested at ICMR-NIRT, Supra-National Reference Laboratory, Chennai between the years 2018 and 2020. All information, including patient demographics and treatment outcomes, was extracted from the NTEP Ni-kshay database. Results: Between 2018 and 2020, 217 patients out of 2557 samples tested were identified with SL-DR by SL-LPA. Among them, 158/217 were FQ-resistant, 34/217 were SLID-resistant, and 25/217 were resistant to both. D94G (Mut3C) of gyrA and a1401g of rrs were the most predominant mutations in the FQ and SLID resistance types, respectively. Favorable (cured and treatment complete) and unfavorable outcomes (died, lost to follow up, treatment failed, and treatment regimen changed) were recorded in a total of 82/217 and 68/217 patients in the NTEP Ni-kshay database. Conclusions: As per the testing algorithm, SL- LPA is used for genotypic DST following identification of first-line resistance, for early detection of SL-DR in India. The fluoroquinolone resistance pattern seen in this study population corelates with the global trend. Early detection of fluoroquinolone resistance and monitoring of treatment outcome can help achieve better patient management