Effect of edaravone on lungs and small intestine in rats with induced radiotherapy

Radiotherapy is a frequently used method for treatment of cancer which is regarded as one of the top two diseases causing premature death worldwide. However, radiotherapy is known to have many side effects. In this study, we evaluated biologically and histologically the possible protective effects of edaravone, the free radical scavenger and neuroprotective agent used to treat amyotrophic lateral sclerosis, on lung and small intestine against radiation-induced early side effects of 15 Gy total body irradiation in single fraction. Thirty-two rats were divided randomly into four equal groups. Groups were administered 15 Gy of external ionizing radiation to the whole body after 30 minutes of EDA administration (a dose of 500 and 50 mg/kg). Rats were sacrified at 72 h of the experiment. Tissues were separated to investigate levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPX) and malondialdehyde (MDA); and evealuate histopathological changings. The protective effect of EDA showed statistically significant in MDA, SOD and GSHPX values of lungs except CAT and statistically significant effect was observed in MDA in small intestine. Also, we showed statistically significant values with histopathological changings. Pediatric cancer patients who have a longer life expectancy are as important as their recovery from their normal life. We are expecting that EDA as a modulator of free radical scavenging pathways in many organs can reduce the side effects of radiation damage on lungs and small intestine

Behavior of watching sports media and playing betting games for high School and college students

Bu araştırmanın amacı, lise ve üniversitelerde öğrenim gören öğrencilerin spor medyasını izleme ve bahis oyunu oynama alışkanlıklarının belirlenmesidir. Bolu ve Sakaryada genel lise, Anadolu lisesi ve meslek liselerinde öğrenim gören 554 öğrenci ile Abant İzzet Baysal Üniversitesi ve Sakarya Üniversitesinde öğrenim gören 521 öğrenci araştırmanın örneklemini oluşturmuştur. Ankete katılan lise öğrencilerinin % 42si hiç bahis oyunu oynamadığını bildirirken, % 38i ara sıra, % 11i ise düzenli olarak oynadığını bildirmiştir. Bu sonuç, 18 yaşından küçüklerin bahis oyunu oynamasının yasak olduğu Türkiye için üzerinde düşünülmesi gereken bir durumdur. Üniversite öğrencilerin % 80.4ü spor medyasını takip etmektedir. Spor medyasını takip eden öğrenciler, en çok televizyondaki spor haberlerini ile spor programlarını takip etmektedir. Katılımcıların % 33ü ara sıra, % 9.2si de düzenli olarak bahis oyunu oynamaktadırlar. Bahis oyunlarını yoğun olarak erkek öğrenciler oynamaktadır. Aileleri dar gelirli üniversite ve lise öğrencileri, para kazanmak amacıyla bahis oyunu oynamaktadır.The purpose of this study is to determine the habits of high school and college students related to watching sports media and playing betting games. The sample of the universe is made up of a total of 554 students, randomly selected form general, Anatolian and vocational high schools and 521 students Abant Izzet Baysal University and Sakarya University in Bolu and Sakarya provinces. 42% of the high school students participating in the survey expressed that they had never played betting games whereas 38% played them sometimes and 11% played regularly. This result is striking in a country in which minors fewer than 18 are not allowed to play betting games by law. 80.4% of the university students are following the sports media. The college students who watch the sports media mostly prefer the sports news and programs on TV. 33% of the participants expressed that they sometimes played betting games whereas 9.2% played them regularly. Male college students play betting games more commonly. University and high school students with lower socio-economic parental income play these games to get some extra money