30 research outputs found

    Negative Islands and obviation by 'wa' in Japanese degree questions

    Get PDF
    This paper aims to explain the observation (not previously reported) that -wa obviates Negative Island effects in Japanese degree questions. The explanation offered ties this obviation to epistemic implications associated with -wa, deriving the latter in a (Neo-)Gricean framework. The explanation relies on Fox & Hackl's (2006) view that Negative Islands in degree questions are due to the necessary failure of a Maximality Presupposition, but it abandons their proposal that such presuppositions must be calculated under the assumption that scales of degrees are invariably dense

    Strict and non-strict negative concord in Hungarian: A unified analysis

    Get PDF
    Surányi (2006) observed that Hungarian has a hybrid (strict + non-strict) negative concord system. This paper proposes a uniform analysis of that system within the general framework of Zeijlstra (2004, 2008) and, especially, Chierchia (2013), with the following new ingredients. Sentential negation NEM is the same full negation in the presence of both strict and non-strict concord items. Preverbal SENKI `n-one’ type negative concord items occupy the specifier position of either NEM `not' or SEM `nor'. The latter, SEM spells out IS `too, even’ in the immediate scope of negation; it is a focus-sensitive head on the clausal spine. SEM can be seen as an overt counterpart of the phonetically null head that Chierchia dubs NEG; it is capable of invoking an abstract (disembodied) negation at the edge of its projection

    Association between KCNJ6 (GIRK2) Gene Polymorphisms and Postoperative Analgesic Requirements after Major Abdominal Surgery

    Get PDF
    Opioids are commonly used as effective analgesics for the treatment of acute and chronic pain. However, considerable individual differences have been widely observed in sensitivity to opioid analgesics. We focused on a G-protein-activated inwardly rectifying potassium (GIRK) channel subunit, GIRK2, that is an important molecule in opioid transmission. In our initial polymorphism search, a total of nine single-nucleotide polymorphisms (SNPs) were identified in the whole exon, 5â€Č-flanking, and exon-intron boundary regions of the KCNJ6 gene encoding GIRK2. Among them, G-1250A and A1032G were selected as representative SNPs for further association studies. In an association study of 129 subjects who underwent major open abdominal surgery, the A/A genotype in the A1032G SNP and -1250G/1032A haplotype were significantly associated with increased postoperative analgesic requirements compared with other genotypes and haplotypes. The total dose (mean±SEM) of rescue analgesics converted to equivalent oral morphine doses was 20.45±9.27 mg, 10.84±2.24 mg, and 13.07±2.39 mg for the A/A, A/G, and G/G genotypes in the A1032G SNP, respectively. Additionally, KCNJ6 gene expression levels in the 1032A/A subjects were significantly decreased compared with the 1032A/G and 1032G/G subjects in a real-time quantitative PCR analysis using human brain tissues, suggesting that the 1032A/A subjects required more analgesics because of lower KCNJ6 gene expression levels and consequently insufficient analgesic effects. The results indicate that the A1032G SNP and G-1250A/A1032G haplotype could serve as markers that predict increased analgesic requirements. Our findings will provide valuable information for achieving satisfactory pain control and open new avenues for personalized pain treatment

    Indeterminate NPIs and Scope

    Get PDF
    From the Proceedings of SALT XVIII, 200

    On the Inverse Trace Conversion and maximal informativeness analysis of Japanese internally-headed relative clauses: A reply to Erlewine and Gould 2016

    No full text
    In this response to Erlewine & Gould (2016), we argue that an account of internally-headed relative clauses using Inverse Trace Conversion and the maximal informativeness semantics for definites of von Fintel et al. (2014) does not derive the observed interpretations when the internal head is quantified by certain downward entailing quantifiers and derives no interpretation at all for non-monotonic and some upward entailing quantifiers. We then argue that the cases that Erlewine & Gould (2016) claim to be a newly identified interpretation of internally-headed relatives are actually headless relatives
    corecore