Griess Test Affection (A and B) by Transmission of Contaminants Inside the Barrel of the Shotgun Brand Benelli Super Nova Model

The present investigation arises from the need to investigate and to experiment scientifically if the contaminants established as controlled variable and not contralada can affect performing the procedure described in clause 4 1 of guide 2DC-GU-0024 on performing ballistic testing on weapons firearms pneumatic gas black powder detonating electrical etc and entering ballistic identification systems It can be reasonably inferred that by performing the forty-two tests manipulating solutions A and B of the Griess reagent it is evident that the pollutants transferred to the Interior of the Cannon 4-stroke oil diesel and gasoline do not affect the results for the identification of nitrites Product of combustion during the Shooting phenomenon Case contrary It happens with rainwater since it is observed that the same it affects the elaboration of the test taking into account that without coming into contact with the gunpowder results in a faint pink coloration indicating in a preliminary way that it is Positive for presence of nitrite

Antigen-specific primed cytotoxic T cells eliminate tumour cells in vivo and prevent tumour development, regardless of the presence of anti-apoptotic mutations conferring drug resistance

Cytotoxic CD8+ T (Tc) cells are the main executors of transformed and cancer cells during cancer immunotherapy. The latest clinical results evidence a high efficacy of novel immunotherapy agents that modulate Tc cell activity against bad prognosis cancers. However, it has not been determined yet whether the efficacy of these treatments can be affected by selection of tumoural cells with mutations in the cell death machinery, known to promote drug resistance and cancer recurrence. Here, using a model of prophylactic tumour vaccination based on the LCMV-gp33 antigen and the mouse EL4 T lymphoma, we analysed the molecular mechanism employed by Tc cells to eliminate cancer cells in vivo and the impact of mutations in the apoptotic machinery on tumour development. First of all, we found that Tc cells, and perf and gzmB are required to efficiently eliminate EL4.gp33 cells after LCMV immunisation during short-term assays (1-4 h), and to prevent tumour development in the long term. Furthermore, we show that antigen-pulsed chemoresistant EL4 cells overexpressing Bcl-XL or a dominant negative form of caspase-3 are specifically eliminated from the peritoneum of infected animals, as fast as parental EL4 cells. Notably, antigen-specific Tc cells control the tumour growth of the mutated cells, as efficiently as in the case of parental cells. Altogether, expression of the anti-apoptotic mutations does not confer any advantage for tumour cells neither in the short-term survival nor in long-term tumour formation. Although the mechanism involved in the elimination of the apoptosis-resistant tumour cells is not completely elucidated, neither necroptosis nor pyroptosis seem to be involved. Our results provide the first experimental proof that chemoresistant cancer cells with mutations in the main cell death pathways are efficiently eliminated by Ag-specific Tc cells in vivo during immunotherapy and, thus, provide the molecular basis to treat chemoresistant cancer cells with CD8 Tc-based immunotherapy.This work was supported in part by Fondo Social Europeo (JP) and Ministerio de Economia y Competitividad (SAF2011-25390 (JP), SAF2014-54763-C2-1 (JP) and SAF2017‐83120‐C2‐1‐R). Predoctoral grants/contracts from Fundación Santander/Universidad de Zaragoza (LS and MA), Gobierno de Aragon (DM, LS and PJS) and FPU/Ministerio de Educación, Cultura y Deportes (PML). IUM was supported by Fondo Garantía Empleo Juvenil/INAEM. Julián Pardo was supported by Fundación Aragon I + D (ARAID). Authors would like to acknowledge the use of Servicios Científico Técnicos del CIBA (IACS-Universidad de Zaragoza) and Servicios Apoyo Investigación de la Universidad de Zaragoza.Peer reviewe

El reto de conservar y producir: biodiversidad y sistemas productivos en la cuenca media y baja del río cravo sur

El proyecto “Cravo Sur: río vital: estrategias para la conservación y recuperación de los bosques de la cuenca media y baja del río Cravo Sur en Yopal, San Luis de Palenque y Orocué, Casanare”, fue liderado por la Fundación Palmarito Casanare y la Fundación Cunaguaro, teniendo como socio estratégico al grupo de investigación CAZAO de la Escuela de Ciencias Agrícolas, Pecuarias y del Medio Ambiente –ECAPMA, de la Uni-versidad Nacional Abierta y a Distancia –UNAD CEAD Yopal, sede para Casanare. Esta iniciativa fue financiada por el Fondo Acción a través del Acuerdo para la Conservación de Bosques Tropicales TFCA.Como producto de la investigación, así como de los trabajos realizados por investi-gadores en esta cuenca, nace el libro El reto de conservar y producir: Biodiversidad y Sistemas Productivos de la cuenca media y baja del río Cravo Sur, que corresponde a la expresión de tres aspectos concatenados, para mostrarle al lector la bondad de utilizar la figura de conservación-producción de los ecosistemas de la cuenca media y baja del río Cravo Sur. En el libro se resalta su extraordinaria biodiversidad, los siste-mas productivos presentes y las estrategias de conservación planteadas para mitigar los factores negativos que inciden en la conservación de los paisajes del río Cravo Sur.Se describe en detalle la gran biodiversidad de la cuenca, más de 1000 especies de flo-ra, 400 especies de aves, artrópodos, peces, anfibios, reptiles y mamíferos de la cuen-ca media y baja del Cravo Sur. También se incluyen capítulos dedicados a los felinos y el morrocoy (Chelonoidis carbonarius), en la cuenca del río Cravo Sur y otras cuencas de la Orinoquía, finalizando con las mariposas.Se dedica una segunda parte del libro a la descripción de los sistemas productivos, se analiza para la cuenca del Cravo Sur la ganadería bovina, los cultivos de arroz, el panorama ambiental, social y económico del cultivo de palma de aceite (Elaeis gui-neensis), los sistemas de producción piscícola de pequeña escala y el estado actual de la minería, resaltando las experiencias positivas de producción sostenible y los retos hacia delante.Finalmente, se presentan estrategias de conservación, relacionando experiencias e iniciativas que buscan el fortalecimiento de capacidades territoriales, con miras a con-servar los bosques del río Cravo Sur, descritas en los capítulos de la iniciativa privada, una poderosa herramienta de conservación en la Orinoquía Colombiana; restauración en la cuenca media y baja del río Cravo Sur; fortalecimiento de capacidades locales y finaliza con el capítulo de acuerdos de conservación voluntarios en la cuenca

Spatial variability of the relationships of runoff and sediment yield with weather types throughout the Mediterranean basin

Este artículo contiene 16 páginas, 6 figuras, 2 tablas.Soil degradation by water is a serious environmental problem worldwide, with specific climatic factors being the major causes. We investigated the relationships between synoptic atmospheric patterns (i.e. weather types, WTs) and runoff, erosion and sediment yield throughout the Mediterranean basin by analyzing a large database of natural rainfall events at 68 research sites in 9 countries. Principal Component Analysis (PCA) was used to identify spatial relationships of the different WTs including three hydro-sedimentary variables: rainfall, runoff, and sediment yield (SY, used to refer to both soil erosion measured at plot scale and sediment yield registered at catchment scale). The results indicated 4 spatial classes of rainfall and runoff: (a) northern sites dependent on North (N) and North West (NW) flows; (b) eastern sites dependent on E and NE flows; (c) southern sites dependent on S and SE flows; and, finally, (d) western sites dependent on W and SW flows. Conversely, three spatial classes are identified for SY characterized by: (a) N and NE flows in northern sites (b) E flows in eastern sites, and (c) Wand SW flows in western sites. Most of the rainfall, runoff and SY occurred during a small number of daily events, and just a few WTs accounted for large percentages of the total. Our results confirm that characterization by WT improves understanding of the general conditions under which runoff and SY occur, and provides useful information for understanding the spatial variability of runoff, and SY throughout the Mediterranean basin. The approach used here could be useful to aid of the design of regional water management and soil conservation measures.This research was supported by projects funded by the MINECOFEDER: CGL2014-52135-C3-3-R, CGL2014-59946-R, CGL2015-65569- R, CGL2015-64284-C2-2-R, and PCIN-2017-061/AEI. When this manuscript was first submitted Estela Nadal-Romero and Damià Vericat received a “Ramón y Cajal” postdoctoral contract (RYC-2013-14371 and RYC‐2010‐06264, Spanish Ministry of Economy and Competitiveness, MEC). Damià Vericat is now a Serra Húnter Fellow at the University of Lleida. María Fernández-Raga received a “José Castillejo” postdoctoral grant (Spanish Ministry of Education, Culture and Sports). Carla Ferreira was supported by a post-doctoral research grant from the Portuguese Science and Technology Foundation (SFRH/ BPD/120093/2016). Mariano Moreno-de las Heras received a Juan de la Cierva postdoctoral contract (IJCI-2015-26463) from the MEC. José Andrés López-Tarazón received a Vicenç Mut postdoctoral fellowship from the Autonomous Balearic Government (CAIB PD/038/2016). José Andrés López-Tarazón and Ramon Batalla also acknowledge the Secretariat for Universities and Research of the Department of the Economy and Knowledge of the Autonomous Government of Catalonia for supporting the Consolidated Research Group 2014 SGR 645 (RIUSFluvial Dynamics Research Group), and the CERCA Programme. This paper has benefited from the Lab and Field Data Pool created within the framework of the COST action CONNECTEUR (ES1306).Peer reviewe

Analysis of the spatial variability of the relationships between rainfall, runoff, erosion and sediment yield and synoptic atmospheric patterns around the Mediterranean basin

Trabajo presentado en TERRAenVISION Environmental Issues Today: Scientific Solutions for Societal Issues, celebrado en Barcelona (España) del 27 de enero al 2 de febrero de 2018This contribution results from international collaborative efforts of different research groups around the Mediterranean basin focusing on soil conservation and water management. We will present the most complete database of runoff and soil erosion information and analyze the records from 68 locations, including more than 22458 detail events between 1985-2015. Soil conservation and water planning are two of the most challenging problems around the Mediterranean basin due to climate conditions and human activity. We believe that future advances on understanding soil degradation by water should be developed under global approaches. In this contribution, we will present an analysis of atmospheric conditions, expressed by weather types and the resulted rainfall, runoff, and erosion and sediment yield around the Mediterranean basin. The weather types compile daily information about the different air masses responsible for rainfall, runoff and eventually erosion and sediment yield, and their analyses let us know the synchrony of the response at different sites around the Mediterranean basin. The analyses of the global dataset display different spatial patterns for rainfall, runoff, and sediment yield, related to different atmospheric patterns. This research will be a valuable tool for understanding the evolution of these environmental variables, and therefore it will allow future planning to design regional water management and soil conservation measuresPeer reviewe

A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic

International audiencePolitical responses to the COVID-19 pandemic led to changes in city soundscapes around the globe. From March to October 2020, a consortium of 261 contributors from 35 countries brought together by the Silent Cities project built a unique soundscape recordings collection to report on local acoustic changes in urban areas. We present this collection here, along with metadata including observational descriptions of the local areas from the contributors, open-source environmental data, open-source confinement levels and calculation of acoustic descriptors. We performed a technical validation of the dataset using statistical models run on a subset of manually annotated soundscapes. Results confirmed the large-scale usability of ecoacoustic indices and automatic sound event recognition in the Silent Cities soundscape collection. We expect this dataset to be useful for research in the multidisciplinary field of environmental sciences

A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic

International audiencePolitical responses to the COVID-19 pandemic led to changes in city soundscapes around the globe. From March to October 2020, a consortium of 261 contributors from 35 countries brought together by the Silent Cities project built a unique soundscape recordings collection to report on local acoustic changes in urban areas. We present this collection here, along with metadata including observational descriptions of the local areas from the contributors, open-source environmental data, open-source confinement levels and calculation of acoustic descriptors. We performed a technical validation of the dataset using statistical models run on a subset of manually annotated soundscapes. Results confirmed the large-scale usability of ecoacoustic indices and automatic sound event recognition in the Silent Cities soundscape collection. We expect this dataset to be useful for research in the multidisciplinary field of environmental sciences

Revista Temas Agrarios Volumen 26; Suplemento 1 de 2021

1st International and 2nd National Symposium of Agronomic Sciences: The rebirth of the scientific discussion space for the Colombian Agro.1 Simposio Intenacional y 2 Nacional de Ciencias Agronómicas: El renacer del espacio de discusión científica para el Agro colombiano