The Antibacterial Effect of Some Medicinal Plant Extracts and their Synergistic Effect with Antibiotic and Non-antibiotic Drugs

The aim of the study was assess the antibacterial effect of some medicinal plant extracts and their synergistic antibiotic and non-antibiotic drugs against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The extract of medicinal plants were prepared using Soxhlet apparatus for alcoholic extract, and water reflux for aqueous extracts. The antibacterial activities of extracts were evaluated using the disk diffusion method as well as well diffusion method; the inhibitory zones were recorded in millimeters. The minimal inhibitory concentration (MIC) of the plant extracts against E. coli, S. aureus and P. aeruginosa were assessed using microdilution method. The synergistic effect between plants and extraction of antibiotics and / or Non-antibiotic drugs was assessed using disk diffusion method. The results of this study showed that ethanolic extracts used against E. coli, S. aureus and P. aeruginosa were showed antimicrobial and synergistic effect with most antibiotics better than methanolic and aquatic extracts.Water extracts were showed synergistic effect with the Paracetamol and Loperamide Hcl better than methanolic and ethanolic extracts against E. coli and S. aureus. Ethanolic extracts were showed synergistic effect with the Paracetamol and Loperamide Hcl better than methanolic and aquatic extracts against P. aeruginosa. The results of this study showed that there is a decrease in MIC in case of methanolic extract of E. camaldulensis against E. coli (3.125 mg/ml), and the methanol and aquatic extract of F. sycomorus (leaves) against S.aureus varying from 6.25 to 3.125 mg/ml, and the ethanol extract of E. camaldulensis against P. areuginosa (6.25 mg/ml). Thereby, our results indicate the possibility of using these extracts in the treatment of bacterial infections, and the results of this study was encouraging, despite the need for clinical studies to determine of the real effectiveness and potential toxic effects in vivo. These results was revealed the importance of plant extracts when associated with antibiotic and Non-antibiotic drugs in control of bacteria

التأثير المضاد للميكروبات لبعض المستخلصات النباتية و تفاعلاتها مع غير المضادات الحيوية

The aim of the study was to assess the synergistic effect of some medicinal plant with non-antibiotic drugs against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. We used loperamid HCl, paracetamol and vitamin C as non-antibiotic drugs. The synergistic effect between plant extrcts and Non-antibiotic drugs was assessed using disk diffusion method. The results of this study showed that ethanolic extracts used against E. coli, S. aureus and P. aeruginosa showed antimicrobial and synergistic effect with most antibiotics better than methanolic and aquatic extracts. Water extracts were showed synergistic effect with the Paracetamol and Loperamide HCl better than methanolic and ethanolic extracts against E. coli and S.aureus. Ethanolic extracts showed synergistic effect with the Paracetamol and Loperamide Hcl better than methanolic and aquatic extracts against P. aeruginosa. Thereby, the results of this study were encouraging, despite the need for clinical studies to determine the real effectiveness and potential toxic effects in vivo. These results were revealed the importance of plant extracts when associated with antibiotic and Non-antibiotic drugs in control of bacteria.The aim of the study was to assess the synergistic effect of some medicinal plant with non-antibiotic drugs against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. We used loperamid HCl, paracetamol and vitamin C as non-antibiotic drugs. The synergistic effect between plant extrcts and Non-antibiotic drugs was assessed using disk diffusion method. The results of this study showed that ethanolic extracts used against E. coli, S. aureus and P. aeruginosa showed antimicrobial and synergistic effect with most antibiotics better than methanolic and aquatic extracts. Water extracts were showed synergistic effect with the Paracetamol and Loperamide HCl better than methanolic and ethanolic extracts against E. coli and S.aureus. Ethanolic extracts showed synergistic effect with the Paracetamol and Loperamide Hcl better than methanolic and aquatic extracts against P. aeruginosa. Thereby, the results of this study were encouraging, despite the need for clinical studies to determine the real effectiveness and potential toxic effects in vivo. These results were revealed the importance of plant extracts when associated with antibiotic and Non-antibiotic drugs in control of bacteria

التأثير التآزري لمستخلصات أوراق و قشور ساق الجميز ضد بعض الكائنات الممرضة

The aim of the study was to assess the antibacterial effect of Ficus sycomorusextracts and their synergistic antibiotics against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The extract of medicinal plants were prepared using Soxhlet apparatus for alcoholic extract, and water reflux for aqueous extracts. The results of this study showed that ethanolic extracts of Ficus were showed against E. coli, S. aureusand P. aeruginosa, While Aquatic extract showed synergistic effect with some antibiotics better than organic solvent. The results of this study showed that there is a decrease in MIC in case of methanolic extract of F. sycomorusextracts against selected bacteria. Thereby, our results indicate the possibility of using these extracts in the treatment of bacterial infections, and the results of this study was encouraging, despite the need for clinical studies to determine of the real effectiveness and potential toxic effects in vivo. These results was revealed the importance of plant extracts when associated with antibiotic and in control of bacteria.The aim of the study was to assess the antibacterial effect of Ficus sycomorusextracts and their synergistic antibiotics against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The extract of medicinal plants were prepared using Soxhlet apparatus for alcoholic extract, and water reflux for aqueous extracts. The results of this study showed that ethanolic extracts of Ficus were showed against E. coli, S. aureusand P. aeruginosa, While Aquatic extract showed synergistic effect with some antibiotics better than organic solvent. The results of this study showed that there is a decrease in MIC in case of methanolic extract of F. sycomorusextracts against selected bacteria. Thereby, our results indicate the possibility of using these extracts in the treatment of bacterial infections, and the results of this study was encouraging, despite the need for clinical studies to determine of the real effectiveness and potential toxic effects in vivo. These results was revealed the importance of plant extracts when associated with antibiotic and in control of bacteri