3,562 research outputs found
Ion-Pairing Limits Crystal Growth in Metal-Oxygen Batteries
Aprotic alkali metal-oxygen batteries are widely considered to be promising
high specific energy alternatives to Li-ion batteries. The growth and
dissolution of alkali metal oxides such as Li2O2 in Li-O2 batteries and NaO2
and KO2 in Na- and K-O2 batteries, respectively, is central to the discharge
and charge processes in these batteries. However, crystal growth and
dissolution of the discharge products, especially in aprotic electrolytes, is
poorly understood. In this work, we chose the growth of NaO2 in Na-O2 batteries
as a model system and show that there is a strong correlation between the
electrolyte salt concentration and the NaO2 crystal size. With a combination of
experiments and theory, we argue that the correlation is a direct manifestation
of the strong cation-anion interactions leading to decreased crystal growth
rate at high salt concentrations. Further, we propose and experimentally
demonstrate that cation-coordinating crown molecules are suitable
electrochemically stable electrolyte additives that weaken ion-pairing and
enhance discharge capacities in metal-oxygen batteries while not negatively
affecting their rechargeability.Comment: 13 Pages, 4 Figures, 14 pages of Supplementary Informatio
The psychological-type profile of clergywomen in ordained local ministry in the Church of England : pioneers or custodians?
This study employs psychological-type theory to compare the psychological profile of 144 clergywomen serving in ordained local ministry in the Church of England alongside the established profile of 237 professional mobile clergywomen serving in the Church of England published by Francis, Craig, Whinney, Tilley, and Slater. The data found no significant differences between these two groups of clergywomen in terms of orientations (introversion and extraversion) or in terms of the judging process (thinking and feeling). In terms of the perceiving process, there was a significantly higher proportion of sensing types among those serving in ordained local ministry (70% compared with 35%). In terms of the attitudes, there was a significantly higher proportion of judging types among those serving in ordained local ministry (83% compared with 65%). The combined sensing judging (SJ) temperament accounted for 65% of the clergywomen serving in ordained local ministry, compared with 29% of the clergywomen serving in professional mobile ministry in the earlier study. It is argued that the SJ temperament characterises a custodian style of ministry
On the Potts model partition function in an external field
We study the partition function of Potts model in an external (magnetic)
field, and its connections with the zero-field Potts model partition function.
Using a deletion-contraction formulation for the partition function Z for this
model, we show that it can be expanded in terms of the zero-field partition
function. We also show that Z can be written as a sum over the spanning trees,
and the spanning forests, of a graph G. Our results extend to Z the well-known
spanning tree expansion for the zero-field partition function that arises
though its connections with the Tutte polynomial
Cosmic Ray Electrons in Groups and Clusters of Galaxies: Primary and Secondary Populations from a Numerical Cosmological Simulation
We study the generation and distribution of high energy electrons in cosmic
environment and their observational consequences by carrying out the first
cosmological simulation that includes directly cosmic ray (CR) particles.
Starting from cosmological initial conditions we follow the evolution of
primary and secondary electrons (CRE), CR ions (CRI) and a passive magnetic
field. CRIs and primary CREs are injected and accelerated at large scale
structure shocks. Secondary CREs are continuously generated through inelastic
p-p collisions. We include spatial transport, adiabatic expansion/compression,
Coulomb collisions, bremsstrahlung, synchrotron (SE)and inverse Compton (IC)
emission. We find that, from the perspective of cosmic shock energy and
acceleration efficiency, the few detections of hard X-ray radiation excess
could be explained in the framework of IC emission of primary CREs in clusters
undergoing high accretion/merger phase. Instead, IC emission from both primary
and secondary CREs accounts at most for a small fraction of the radiation
excesses detected in the extreme-UV (except for the Coma cluster as reported by
Bowyer et al.1999). Next, we calculate the SE after normalizing the magnetic
field so that for a Coma-like cluster ^1/2~3 \muG. Our results indicate
that the SE from secondary CREs reproduces several general properties of radio
halos, including the recently found P_1.4GHz vs T relation, the morphology and
polarization of the emitting region and, to some extent, the spectral index.
Moreover, SE from primary CREs turns out sufficient to power extended regions
resembling radio relics observed at the outskirts of clusters. Again we find
striking resemblance between morphology, polarization and spectral index of our
synthetic maps and those reported in the literature.Comment: emulateapj, 27 pages, 10 figures, 5 tables; ApJ in pres
Small cell carcinoma of the anus: a case report
Small cell carcinoma of the anus is a very rare but aggressive tumour. We present a case of a 60-year old lady with small cell carcinoma of the anus. She had no metastatic disease on presentation. She had chemotherapy and radiotherapy but developed distant metastasis after completion of treatment. Immunohistochemistry is required to make a diagnosis. Chemotherapy remains the mainstay of treatment for small cell carcinoma of the anus with or without metastatic disease. Radiotherapy is for local control and relief of symptoms
Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study
Psychosis is a common presenting feature in antibody-mediated encephalitis, for which prompt recognition and treatment usually leads to remission. We aimed to investigate whether people with circumscribed schizophrenia-like illnesses have such antibodies—especially antibodies against the N-methyl-D-aspartate receptor (NMDAR)—more commonly than do healthy controls.
We recruited patients aged 14–35 years presenting to any of 35 mental health services sites across England with first-episode psychosis, less than 6 weeks of treatment with antipsychotic medication, and a score of 4 or more on at least one selected Positive and Negative Syndrome Scale (PANSS) item. Patients and controls provided venous blood samples. We completed standardised symptom rating scales (PANSS, ACE-III, GAF) at baseline, and tested serum samples for antibodies against NMDAR, LGI1, CASPR2, the GABAA receptor, and the AMPA receptor using live cell-based assays. Treating clinicians assessed outcomes of ICD diagnosis and functioning (GAF) at 6 months. We included healthy controls from the general population, recruited as part of another study in Cambridge, UK.
Between Feb 1, 2013, and Aug 31, 2014, we enrolled 228 patients with first-episode psychosis and 105 healthy controls. 20 (9%) of 228 patients had serum antibodies against one or more of the neuronal cell surface antibodies compared with four (4%) of 105 controls (unadjusted odds ratio 2·4, 95% CI 0·8–7·3). These associations remained non-significant when adjusted for current cigarette smoking, alcohol consumption, and illicit drug use. Seven (3%) patients had NMDAR antibodies compared with no controls (p=0·0204). The other antibodies did not differ between groups. Antibody-positive patients had lower PANSS positive, PANSS total, and catatonia scores than did antibody-negative patients. Patients had comparable scores on other PANSS items, ACE-III, and GAF at baseline, with no difference in outcomes at 6 months.
Some patients with first-episode psychosis had antibodies against NMDAR that might be relevant to their illness, but did not differ from patients without NMDAR antibodies in clinical characteristics. Our study suggests that the only way to detect patients with these potentially pathogenic antibodies is to screen all patients with first-episode psychosis at first presentation.Medical Research Counci
The structure of the PapD-PapGII pilin complex reveals an open and flexible P5 pocket
P pili are hairlike polymeric structures that mediate binding of uropathogenic Escherichia coli to the surface of the kidney via the PapG adhesin at their tips. PapG is composed of two domains: a lectin domain at the tip of the pilus followed by a pilin domain that comprises the initial polymerizing subunit of the 1,000-plus-subunit heteropolymeric pilus fiber. Prior to assembly, periplasmic pilin domains bind to a chaperone, PapD. PapD mediates donor strand complementation, in which a beta strand of PapD temporarily completes the pilin domain's fold, preventing premature, nonproductive interactions with other pilin subunits and facilitating subunit folding. Chaperone-subunit complexes are delivered to the outer membrane usher where donor strand exchange (DSE) replaces PapD's donated beta strand with an amino-terminal extension on the next incoming pilin subunit. This occurs via a zip-in-zip-out mechanism that initiates at a relatively accessible hydrophobic space termed the P5 pocket on the terminally incorporated pilus subunit. Here, we solve the structure of PapD in complex with the pilin domain of isoform II of PapG (PapGIIp). Our data revealed that PapGIIp adopts an immunoglobulin fold with a missing seventh strand, complemented in parallel by the G1 PapD strand, typical of pilin subunits. Comparisons with other chaperone-pilin complexes indicated that the interactive surfaces are highly conserved. Interestingly, the PapGIIp P5 pocket was in an open conformation, which, as molecular dynamics simulations revealed, switches between an open and a closed conformation due to the flexibility of the surrounding loops. Our study reveals the structural details of the DSE mechanism
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Purification and functional characterisation of rhiminopeptidase A, a novel aminopeptidase from the venom of Bitis gabonica rhinoceros
This study describes the discovery and characterisation of a novel aminopeptidase A from the venom of B. g. rhinoceros and highlights its potential biological importance. Similar to mammalian aminopeptidases, rhiminopeptidase A might be capable of playing roles in altering the blood pressure and brain function of victims. Furthermore, it could have additional effects on the biological functions of other host proteins by cleaving their N-terminal amino acids. This study points towards the importance of complete analysis of individual components of snake venom in order to develop effective therapies for snake bites
Effect on nursery and field performance of Pinus patula seedlings after inoculation with Fusarium circinatum
Fusarium circinatum is an important fungal pathogen of Pinus species. In South Africa, it is the most significant
pathogen of Pinus patula seedlings in forestry nurseries where it presents a substantial constraint to productivity
and can continue to cause mortality in-field for up to two years after establishment. This study describes
the results from two trials where P. patula seedlings were inoculated with F. circinatum to determine the impact
of the pathogen on nursery and field performance. Seedlings were also subjected to water stress treatments to
ascertain whether this would trigger the onset of disease symptoms. Inoculum load and timing of inoculation
had significant effects on seedling survival in both the nursery and field. High inoculum concentrations caused
greater levels of mortality and, where seedlings were inoculated at a young age, they showed higher levels of
susceptibility to F. circinatum. Temporary water-stress in the nursery produced smaller plants and improved
in-field survival, but this treatment did not trigger higher mortality in inoculated treatments. On the other hand,
transplant stress was a major contributor to the higher levels of mortality observed in inoculated treatments.
Overall, these studies confirmed that infection in the nursery leads to the disease problems observed during early
plant establishment in the field.Forestry South Africa provided funding via the South African Pitch Canker Control
Programmehttp://www.tandfonline.com/loi/tsfs202015-05-30hb201
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