Quenching Performance of Surfactant-Containing and Surfactant-Free Fluorophore-Doped Mesoporous Silica Films for Nitroaromatic Compound Detection

Various surfactant-templated, mesoporous silica thin films containing a phenyl-substituted pyrene fluorophore were prepared and tested as sensors for the nitroaromatic compound 2,4-dinitrotoluene (DNT). The effects of materials parameters on quenching efficiency were evaluated, including the influence of mesopore architecture (wormlike, cubic, or hexagonal mesopores), the presence or absence of the templating surfactant in the mesopores, and the mode of fluorophore incorporation (doping, impregnating, or grafting). Among films with similar components, films with wormlike mesopore architecture exhibited a better quenching performance than those with 2D-hexagonal or 3D-hexagonal mesopore structure. Surfactant-free, fluorophore-bridged films with wormlike mesopores showed the best quenching performance (43% after 5 s and 88% after 60 s), which compares favorably with state-of-the-art sensors based on fluorescent conjugated polymers. Surfactant-containing, fluorophore-doped films with wormlike mesopores were also effectively quenched by DNT, with 39% quenching after 45 s and 94% of quenching after 405 s. It is notable that the surfactant blocks the diffusion of DNT only slightly while it enhances the binding of DNT to the film, boosting the quenching performance

E_tynerensis_190_genomic_regions

This nexus file contains a concatenated alignment of 190 nuclear gene regions from 121 loci collected from 28 populations of the Oklahoma Salamanders (Eurycea tynerensis) using anchored-hybrid enrichment (AHE)

The effects of water injection dredging on low-salinity estuarine ecosystems: implications for fish and macroinvertebrate communities

Subaqueous dredging is a management activity undertaken globally to improve navigation, remove contaminants, mitigate flood risk and/or generate aggregate. Water Injection Dredging (WID) is a hydrodynamic technique involving the turbation and downstream displacement of fine sediments using vessel-mounted water jets. Despite the technique being widely applied internationally, the environmental and ecological effects of WID are poorly understood. For the first time, this study used a Before-After-Control-Impact (BACI) experimental design to assess the effects of WID on water physicochemistry, and macroinvertebrate and fish communities within a 5.7 km-long reach of tidal river. WID targeted the central channel (thalweg) to avoid disturbance of the channel margins and banks. Mean but not peak turbidity levels were substantially elevated, and dissolved oxygen levels were reduced during periods of WID, although effects were relatively short-lived (≈3 h on average). Dredging resulted in significant reductions in benthic macroinvertebrate community abundance (particularly taxa that burrow into fine sediments), taxonomic richness and diversity. In contrast, minor changes were detected in marginal macroinvertebrate communities within and downstream of the dredged reach following WID. Reductions in fish taxonomic richness and diversity were recorded downstream of the dredged reach most likely due to behavioural avoidance of the sediment plume. No visibly stressed or dead fish were sampled during dredging. Results suggest that mobile organisms and marginal communities were largely unaffected by thalweg WID and that the technique represents a more ecologically sensitive alternative to traditional channel margin mechanical dredging techniques

Characterising the geomorphological and physicochemical effects of water injection dredging on estuarine systems

Dredging is a globally important aquatic system management activity, used for navigation improvement, contamination removal, aggregate production and/or flood risk mitigation. Despite widespread application, understanding of the environmental effects of some dredging types remains limited. Field campaigns in 2016 and 2017 in the River Parrett estuary, UK, therefore investigated the geomorphic and physicochemical effects of Water Injection Dredging (WID), a poorly studied hydrodynamic dredging technology. WID, applied to restore channel capacity for the maintenance of flood water conveyance in the tidal River Parrett, influenced surface elevations but not grain-size characteristics of dredged bed sediments. Topographic alterations due to the 2016 WID operation were short-lived, lasting less than 10 months, although benefits of the 2017 WID operation, in terms of volumetric change, outlasted the ≈12-month study period. Dredging had a significant impact on water physicochemistry (pH, dissolved oxygen, total suspended solids and turbidity) when comparing pre- and during-dredging conditions within the dredge reach, although time-series analysis found dredging effects were comparable in magnitude to tidal effects for some parameters. WID is typically targeted at the thalweg and not the banks, rendering the geomorphic signature of the method different to those of other, often more invasive dredging technologies (e.g. mechanical dredging methods). Further, thalweg not bankside dredging may have potential positive ecological implications, particularly where the majority of biomass is located within the channel margins, as in the tidal River Parrett. Collectively, data suggest WID can be an effective method for sediment dispersal within tidal systems although regular application may be required to maintain cross sectional areas, particularly where management precedes periods of low flows and/or high rates of sediment accumulation. In future, more work is required to better understand both the physical and ecological implications of WID as a flood risk management tool in estuaries and rivers

Additional file 3: of Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia

Mutagenesis data and RTEL1-mapping for Fan et al. and Kuper et al. XPD variants. (XLSX 13 kb

Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (<i>Capnodium</i> sp.)

Drug-resistant bacteria continue to make many existing antibiotic classes ineffective. In order to avoid a future epidemic from drug-resistant bacterial infections, new antibiotics with new modes of action are needed. In an antibiotic screening program for new drug leads with new modes of action using antisense <i>Staphylococcus aureus</i> Fitness Test screening, we discovered a new tetramic acid, methiosetin, from a tropical sooty mold, <i>Capnodium</i> sp. The fungus also produced epicorazine A, a known antibiotic. The structure and relative configuration of methiosetin was elucidated by 2D NMR and ESIMS techniques. Methiosetin and epicorazine A showed weak to modest antibacterial activity against <i>S. aureus</i> and <i>Haemophilus influenzae</i>. The isolation, structure elucidation, and antibacterial activity of both compounds are described