the Interitance and Transformation of Traditional Huizhou Elements into New Forms: Redesigning Lu Village

The hardest part in the preservation of traditional culture is the inheritance of its spiritual meaning. Therefore, it is important to adhere to the creation of regional architecture through the interpretation of local environment and climate, ethnic culture and architecture influenced by traditional philosophies. In the context of global acculturation, it is necessary to revitalize domestic architectural expression by promoting the fusion of world culture and local traditional culture. The historic Huizhou region lies in what is now Anhui province. With all the tangible and intangible cultural heritage it bestows, it is not only one of the many cultural treasures of China, but also provides possible inspiration for modern architectural design. Therefore, by research of Huizhou area, this thesis defines the hidden order as well as the ethic and spiritual connotations of traditional culture and architecture of Huizhou by examining the intangible cultural factors affecting architecture. The ultimate goal is to apply these interpretations of intangible cultural heritage hidden behind the tangible cultural heritage to a contemporary architectural expression in Huizhou in addition to preserving existing historical buildings. After the research part, the Section 2 demonstrates preservation and redesign of a particular case in Huizhou, namely the Lu Village. By exploring the tangible and intangible characteristics of Lu Village, the aim is to find the harmonious relationship between past, present and future. Therefore, the rehabilitation and redevelopment plan of Lu Village is based on the discussion on Huizhou in general (section1) and special features of Lu Village in order to preserve old when appropriate and to design new in accordance to the spirit of place, and to improve the living conditions which ensures life of future generation

Vibration-modal analysis model for multi-span pipeline with different support conditions

Abstract Vibration characteristics analysis is important in the design of multi-span pipeline with different support conditions. In order to analyze the natural frequency and the vibration modal of the multi-span pipeline, a matrix transfer method is proposed in this paper. With the multi-span pipeline divided into single-span pipes, the transmission formulas for the deflection, angle, bending and shear between two adjacent spans are deduced, in combination with the Krylov function solution of the free vibration equation for the single-span pipe, and the constraint condition between the two adjacent spans of the multi-span pipeline. According to the boundary conditions on the starting and ending spans, the natural frequency equation and the vibration modal function between two adjacent spans of the multi-span pipeline are presented. The FORTRAN program based on the above principle is written, and the natural vibration frequencies and the vibration modals of two typical multi-span pipelines are investigated and compared with the results from ABAQUS. It is shown that the model presented in this paper is efficient in the analysis of multi-span pipeline and has the advantages of high computational efficiency and convenience for engineering practice application

Assessing Distributional and Perceived Equity of Urban Green Spaces in Qingdao’s Historic Urban Area

Urban green spaces (UGSs) satisfy citizens’ physical and psychological demands and are considered an integral part of sustainable urban development. However, the distribution of UGS is often uneven, especially in historic urban areas with high building density and limited facilities, thus leading to issues of green inequity. This study examines two dimensions of green equity in Qingdao’s historic urban area, distributional equity and perceived equity, based on a fine-grained division of units and districts. Distributional equity is analyzed using the Gaussian two-step floating catchment area (G2SFCA) method and Gini coefficient to accurately calculate the equity in distribution and accessibility of UGSs. The perceived equity is assessed through the green view index (GVI) and location quotient of the streets, which represents citizens’ visual perception of green quality. Based on these analyses, a dual-perspective evaluation model of green equity is conducted, and the results show a significant imbalance of greenery supply and population demand in the historical urban area of Qingdao. This disequilibrium in green spaces leads to 62.20% of people living with low green equity, while only 8.12% experience high green equity. To maximize social justice, priority should be given to improving the 15 districts with low green equity; doing so could effectively reduce green inequity within historic urban areas where facilities and resources are relatively scarce, thereby improving the efficiency of urban renewal efforts

An Experimental and Numerical Study of the Winter Outdoor Wind Environment in High-Rise Residential Complexes in a Coastal City in Northern China

In recent years, residents in high-rise residential complexes (HRCs) in China have been placing an increasing demand on the living quality in HRCs. Particularly, the outdoor wind conditions are garnering more attention; however, few studies on the wind conditions within HRCs with densely arranged buildings and high plot ratios have been reported. Therefore, this study investigated the relation between the buildings’ layouts in HRCs and their wind conditions and it proposes optimization strategies to enhance body comfort in their outdoor environments. The research methods in this work involved field surveys, computational fluid dynamics (CFD) simulations, and field monitoring. The field surveys were used to determine the types of activities undertaken by the residents in the selected HRCs and their perceptions of the wind conditions within the HRCs. Field monitoring was primarily conducted to measure the present wind conditions in the HRCs. The CFD simulations were performed to analyze the interactions between individual buildings and the wind as well as the performance of the wind conditions in the HRCs before and after a building layout optimization. The simulation results and monitoring data showed that the present wind conditions in the HRCs were uncomfortable due to high wind speeds (exceeding 5 m/s) and large windless areas. To achieve a comfortable outdoor wind environment, future HRCs should adopt a point-to-point building layout and the buildings should be oriented south. Moreover, the ratios of the height to width (Hb/Wb) for individual buildings should be kept at approximately 1.33. For existing HRCs, landscape walls, trees, and moveable windbreak panels can be used to reduce the wind speeds, especially in open exit/entrance areas and windward areas

An Experimental and Numerical Study of the Winter Outdoor Wind Environment in High-Rise Residential Complexes in a Coastal City in Northern China

In recent years, residents in high-rise residential complexes (HRCs) in China have been placing an increasing demand on the living quality in HRCs. Particularly, the outdoor wind conditions are garnering more attention; however, few studies on the wind conditions within HRCs with densely arranged buildings and high plot ratios have been reported. Therefore, this study investigated the relation between the buildings’ layouts in HRCs and their wind conditions and it proposes optimization strategies to enhance body comfort in their outdoor environments. The research methods in this work involved field surveys, computational fluid dynamics (CFD) simulations, and field monitoring. The field surveys were used to determine the types of activities undertaken by the residents in the selected HRCs and their perceptions of the wind conditions within the HRCs. Field monitoring was primarily conducted to measure the present wind conditions in the HRCs. The CFD simulations were performed to analyze the interactions between individual buildings and the wind as well as the performance of the wind conditions in the HRCs before and after a building layout optimization. The simulation results and monitoring data showed that the present wind conditions in the HRCs were uncomfortable due to high wind speeds (exceeding 5 m/s) and large windless areas. To achieve a comfortable outdoor wind environment, future HRCs should adopt a point-to-point building layout and the buildings should be oriented south. Moreover, the ratios of the height to width (Hb/Wb) for individual buildings should be kept at approximately 1.33. For existing HRCs, landscape walls, trees, and moveable windbreak panels can be used to reduce the wind speeds, especially in open exit/entrance areas and windward areas

A pilot trial of consolidation bevacizumab after hypo‐fractionated concurrent chemoradiotherapy in patients with unresectable locally advanced non‐squamous non‐small‐cell lung cancer

Abstract Purpose To determine the feasibility of incorporating bevacizumab consolidation into hypo‐fractionated concurrent chemoradiotherapy (hypo‐CCRT) for patients with unresectable locally advanced non‐squamous non‐small‐cell lung cancer (LA‐NS‐NSCLC). Patients and Methods Eligible patients were treated with hypo‐RT (40Gy in 10 fractions) followed by hypo‐boost (24‐28Gy in 6–7 fractions), along with concurrent weekly chemotherapy. Patients who completed the hypo‐CCRT without experiencing ≥G2 toxicities received consolidation bevacizumab every 3 weeks for up to 1 year, until disease progression or unacceptable treatment‐related toxicities. The primary endpoint was the risk of G4 or higher hemorrhage. Secondary endpoints included progression‐free survival (PFS), overall survival (OS), locoregional failure‐free survival (LRFS), distant metastasis‐free survival (DMFS), and objective response rate (ORR). All time‐to‐event endpoints (OS, PFS, LRFS, and DMFS) were measured from the start of radiotherapy. Results Between December 2017 and July 2020, a total of 27 patients were included in the analysis, with a median follow‐up duration of 28.0 months. One patient (3.7%) developed G5 hemorrhage during bevacizumab consolidation. Additionally, seven patients (25.9%) had G3 cough and three patients (11.1%) experienced G3 pneumonitis. The ORR for the entire cohort was 92.6%. The median OS was 37.0 months (95% confidence interval, 8.9–65.1 months), the median PFS was 16.0 months (95% confidence interval, 14.0–18.0 months), the median LRFS was not reached, and the median DMFS was 18.0 months. Conclusions This pilot study met its goal of demonstrating the tolerability of consolidation bevacizumab after hypo‐CCRT. Further investigation of antiangiogenic and immunotherapy combinations in LA‐NSCLC is warranted, while the potential for grade 3 respiratory toxicities should be taken into consideration

Comparative Transcriptomes Analysis of Red- and White-Fleshed Apples in an F1 Population of Malus sieversii f. niedzwetzkyana Crossed with M. domestica 'Fuji'.

Transcriptome profiles of the red- and white-fleshed apples in an F1 segregating population of Malus sieversii f.Niedzwetzkyana and M.domestica 'Fuji' were generated using the next-generation high-throughput RNA sequencing (RNA-Seq) technology and compared. A total of 114 differentially expressed genes (DEGs) were obtained, of which 88 were up-regulated and 26 were down-regulated in red-fleshed apples. The 88 up-regulated genes were enriched with those related to flavonoid biosynthetic process and stress responses. Further analysis identified 22 genes associated with flavonoid biosynthetic process and 68 genes that may be related to stress responses. Furthermore, the expression of 20 up-regulated candidate genes (10 related to flavonoid biosynthesis, two encoding MYB transcription factors and eight related to stress responses) and 10 down-regulated genes were validated by quantitative real-time PCR. After exploring the possible regulatory network, we speculated that flavonoid metabolism might be involved in stress responses in red-fleshed apple. Our findings provide a theoretical basis for further enriching gene resources associated with flavonoid synthesis and stress responses of fruit trees and for breeding elite apples with high flavonoid content and/or increased stress tolerances

Functional categories of genes with changed expression between red- and white-fleshed apples.

<p>Functional categories of genes with changed expression between red- and white-fleshed apples.</p

Up-regulated genes involved in both the flavonoid biosynthetic process and stress response in red-fleshed apples.

<p>Up-regulated genes involved in both the flavonoid biosynthetic process and stress response in red-fleshed apples.</p

Comparative Transcriptomes Analysis of Red- and White-Fleshed Apples in an F₁ Population of <i>Malus sieversii f</i>. <i>niedzwetzkyana</i> Crossed with <i>M</i>. <i>domestica</i> ‘Fuji’

<div><p>Transcriptome profiles of the red- and white-fleshed apples in an F₁segregating population of <i>Malus sieversii f</i>.<i>Niedzwetzkyana</i> and <i>M</i>.<i>domestica</i> ‘Fuji’ were generated using the next-generation high-throughput RNA sequencing (RNA-Seq) technology and compared. A total of 114 differentially expressed genes (DEGs) were obtained, of which 88 were up-regulated and 26 were down-regulated in red-fleshed apples. The 88 up-regulated genes were enriched with those related to flavonoid biosynthetic process and stress responses. Further analysis identified 22 genes associated with flavonoid biosynthetic process and 68 genes that may be related to stress responses. Furthermore, the expression of 20 up-regulated candidate genes (10 related to flavonoid biosynthesis, two encoding MYB transcription factors and eight related to stress responses) and 10 down-regulated genes were validated by quantitative real-time PCR. After exploring the possible regulatory network, we speculated that flavonoid metabolism might be involved in stress responses in red-fleshed apple. Our findings provide a theoretical basis for further enriching gene resources associated with flavonoid synthesis and stress responses of fruit trees and for breeding elite apples with high flavonoid content and/or increased stress tolerances.</p></div