Shame and psychopathology. Its role in the genesis and perpetuation of different disorders

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Electroconvulsive therapy for Patients with Intellectual Disability. When and how?

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Electroconvulsive therapy for Depression in Anorexia Nervosa. A review

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Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve

Background—Contrast fractional flow reserve (cFFR) is a method for assessing functional significance of coronary stenoses, which is more accurate than resting indices and does not require adenosine. However, contrast media volume and osmolality may affect the degree of hyperemia and therefore diagnostic performance. Methods and Results—cFFR, instantaneous wave–free ratio, distal pressure/aortic pressure at rest, and FFR were measured in 763 patients from 12 centers. We compared the diagnostic performance of cFFR between patients receiving low or iso-osmolality contrast (n=574 versus 189) and low or high contrast volume (n=341 versus 422) using FFR≤0.80 as a reference standard. The sensitivity, specificity, and overall accuracy of cFFR for the low versus iso-osmolality groups were 73%, 93%, and 85% versus 87%, 90%, and 89%, and for the low versus high contrast volume groups were 69%, 99%, and 83% versus 82%, 93%, and 88%. By receiver operating characteristics (ROC) analysis, cFFR provided better diagnostic performance than resting indices regardless of contrast osmolality and volume (P<0.001 for all groups). There was no significant difference between the area under the curve of cFFR in the low- and iso-osmolality groups (0.938 versus 0.957; P=0.40) and in the low- and high-volume groups (0.939 versus 0.949; P=0.61). Multivariable logistic regression analysis showed that neither contrast osmolality nor volume affected the overall accuracy of cFFR; however, both affected the sensitivity and specificity. Conclusions—The overall accuracy of cFFR is greater than instantaneous wave–free ratio and distal pressure/aortic pressure and not significantly affected by contrast volume and osmolality. However, contrast volume and osmolality do affect the sensitivity and specificity of cFFR

Geodynamic context for the deposition of coarse-grained deep-water axial channel systems in the Patagonian Andes

We present field and seismic evidence for the existence of Coniacian–Campanian syntectonic angular unconformities within basal foreland basin sequences of the Austral or Magallanes Basin, with implications for the understanding of deformation and sedimentation in the southern Patagonian Andes. The studied sequences belong to the mainly turbiditic Upper Cretaceous Cerro Toro Formation that includes a world-class example of conglomerate-filled deep-water channel bodies deposited in an axial foredeep depocentre. We present multiple evidence of syntectonic deposition showing that the present internal domain of the fold-thrust belt was an active Coniacian–Campanian wedge-top depozone where deposition of turbidites and conglomerate channels of Cerro Toro took place. Cretaceous synsedimentary deformation was dominated by positive inversion of Jurassic extensional structures that produced elongated axial submarine trenches separated by structural highs controlling the development and distribution of axial channels. The position of Coniacian-Campanian unconformities indicates a ca. 50–80 km advance of the orogenic front throughout the internal domain, implying that Late Cretaceous deformation was more significant in terms of widening the orogenic wedge than all subsequent Andean deformation stages. This south Patagonian orogenic event can be related to compressional stresses generated by the combination of both the collision of the western margin of Rocas Verdes Basin during its closure, and Atlantic ridge push forces due to its accelerated opening, during a global-scale plate reorganization event.Fil: Ghiglione, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos; ArgentinaFil: Likerman, Jeremias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos; ArgentinaFil: Barberon, Vanesa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos; ArgentinaFil: Giambiagi, Laura Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Aguirre-Urreta, Maria Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos; ArgentinaFil: Suarez, F.

PEMANFAATAN LIMBAH STRAPPING BAND dan STYROFOAM dengan MENGGUNAKAN PASIR MOJOKERTO untuk BATA RINGAN

Limbah strapping band dan styrofoam dari bekas kemasan untuk makanan dan pengikat kemasan elektronik saat ini banyak digunakan di pusat pembelanjaan, hal ini akan berdampak terhadap pencemaran lingkungan ,  karena limbah strapping band dan styrofoam yang berbahan dasar plastik dan sulit diurai oleh tanah. Dalam rangka mengurangi limbah yang berbahan plastic untuk menjaga pelestarian lingkungan dengan upaya memanfaatkan limbah tersebut sebagai bahan penyusun dalam campuran bata ringan. Penelitian ini bertujuan untuk pemamfaatan limbah fiber strapping band dan styrofoam untuk campuran penyusun bata ringan dengan menguji terhadap Kuattekan dan berat volume bata ringan. Dalam penelitian ini penambahan fiber Strapping Band dengan panjang 40 mm dan 50 mm dan komposisi0%, 3%, 6%, 9% terhadap berat semen, styrofoam 20 % dan foam agent 0,6 l/m3. Metode yang digunakan adalah metode eksperimental yang dilaksanakan di Laboratorium material beton. Benda uji Berbentuk silinder dengan diameter 15 cm dan tinggi 30 cm dengan jumlah benda uji 72 untuk pengujian kuat tekan, kuat tarikbelah dan Berat Volume pada umur 21 dan 28 hari. Dari hasil penelitian ,terjadi peningkatan terhadap kuat tekan dan  kuat tarik belah , sedangkan berat volume mengalami penurunan yang signifikan setelah penambahan serat fiber strapping band, Kuat tekan maksimum terjadi pada komposisi serat fiber strapping band 9% sebesar 7,445  Mpa (meningkat139,4%) dan kuat tarik belah sebesar 0,94  Mpa (meningkat54,1%), sedangkan berat volume hasilnya 1421 kg/m3 (lebihringan2,34%), bila dibandingkan dengan bata ringan tanpa serat. Berat volume standart beton ringan antara 600 - 1600 kg/m

The effect of amoxicillin on dental enamel development in vivo

The exposure to amoxicillin has been associated with molar incisor hypomineralization. This study aimed to determine if amoxicillin disturbs the enamel mineralization in in vivo experiments. Fifteen pregnant rats were randomly assigned into three groups to received daily phosphatase-buffered saline or amoxicillin as either 100 or 500 mg/kg. Mice received treatment from day 13 of pregnancy to day 40 postnatal. After birth, the offsprings from each litter continued to receive the same treatment according to their respective group. Calcium (Ca) and phosphorus (P) content in the dental hard tissues were analyzed from 60 upper first molars and 60 upper incisors by the complexometric titration method and colorimetric analysis using a spectrophotometer at 680 nm, respectively. Lower incisors were analyzed by X-ray microtomography, it was measured the electron density of lingual and buccal enamel, and the enamel and dentin thickness. Differences in Ca and P content and electron density among the groups were analyzed by one-way ANOVA. There was no significant difference on enamel electron density and thickness among the groups (p > 0.05). However, in incisors, the higher dose of amoxicillin decreased markedly the electron density in some rats. There were no statistically significant differences in Ca (p = 0.180) or P content (p = 0.054), although the higher dose of amoxicillin could affect the enamel in some animals. The amoxicillin did not significantly alter the enamel mineralization and thickness in rats. © 2020Peer reviewe

Adding Student Video Projects to Physics Courses

Physics students have traditionally prepared many kinds of reports—laboratory, activity, project, and even book or article reports. Smartphones and YouTube videos are familiar cultural objects to current students, and our students use smartphone cameras to include photographs of apparatus, phenomena, hand-sketched figures, graphs, and mathematical equations in their physics reports. Here we present basic techniques for physics students to use smartphones and tablets to create short (\u3c 5 min) end-of-semester video projects. Our students mainly use Apple Computer’s iPad1 tablets, but also other tablets and various smartphones. Finally we discuss appropriate instructor expectations and grading. Similar non-physics student video reporting efforts were reported using video cameras by Kearney,2 and Hechter and Guy.

Continuum of vasodilator stress from rest to contrast medium to adenosine hyperemia for fractional flow reserve assessment

Objectives: This study compared the diagnostic performance with adenosine-derived fractional flow reserve (FFR) ≤0.8 of contrast-based FFR (cFFR), resting distal pressure (Pd)/aortic pressure (Pa), and the instantaneous wave-free ratio (iFR). Background: FFR objectively identifies lesions that benefit from medical therapy versus revascularization. However, FFR requires maximal vasodilation, usually achieved with adenosine. Radiographic contrast injection causes submaximal coronary hyperemia. Therefore, intracoronary contrast could provide an easy and inexpensive tool for predicting FFR. Methods: We recruited patients undergoing routine FFR assessment and made paired, repeated measurements of all physiology metrics (Pd/Pa, iFR, cFFR, and FFR). Contrast medium and dose were per local practice, as was the dose of intracoronary adenosine. Operators were encouraged to perform both intracoronary and intravenous adenosine assessments and a final drift check to assess wire calibration. A central core lab analyzed blinded pressure tracings in a standardized fashion. Results: A total of 763 subjects were enrolled from 12 international centers. Contrast volume was 8 ± 2 ml per measurement, and 8 different contrast media were used. Repeated measurements of each metric showed a bias <0.005, but a lower SD (less variability) for cFFR than resting indexes. Although Pd/Pa and iFR demonstrated equivalent performance against FFR ≤0.8 (78.5% vs. 79.9% accuracy; p = 0.78; area under the receiver-operating characteristic curve: 0.875 vs. 0.881; p = 0.35), cFFR improved both metrics (85.8% accuracy and 0.930 area; p < 0.001 for each) with an optimal binary threshold of 0.83. A hybrid decision-making strategy using cFFR required adenosine less often than when based on either Pd/Pa or iFR. Conclusions: cFFR provides diagnostic performance superior to that of Pd/Pa or iFR for predicting FFR. For clinical scenarios or health care systems in which adenosine is contraindicated or prohibitively expensive, cFFR offers a universal technique to simplify invasive coronary physiological assessments. Yet FFR remains the reference standard for diagnostic certainty as even cFFR reached only ∼85% agreement

Agreement of the resting distal to aortic coronary pressure with the instantaneous wave-free ratio

Background: Recently, 2 randomized controlled trials showed that the instantaneous wave-free ratio (iFR), a resting coronary physiological index, is noninferior to fractional flow reserve for guiding revascularization. The resting distal to aortic coronary pressure (Pd/Pa) measured at rest is another adenosine-free index widely available in the cardiac catheterization laboratory; however, little is known about the agreement of Pd/Pa using iFR as a reference standard. Objectives: The goal of this study was to investigate the agreement of Pd/Pa with iFR. Methods: A total of 763 patients were prospectively enrolled from 12 institutions. iFR and Pd/Pa were measured under resting conditions. Using iFR ≤0.89 as a reference standard, the agreement of Pd/Pa and its best cutoff value were assessed. Results: According to the independent core laboratory analysis, iFR and Pd/Pa were analyzable in 627 and 733 patients (82.2% vs. 96.1%; p < 0.001), respectively. The median iFR and Pd/Pa were 0.90 (interquartile range: 0.85 to 0.94) and 0.92 (interquartile range: 0.88 to 0.95), and the 2 indices were highly correlated (R2 = 0.93; p < 0.001; iFR = 1.31 * Pd/Pa –0.31). According to the receiver-operating characteristic curve analysis, Pd/Pa showed excellent agreement (area under the curve: 0.98; 95% confidence interval: 0.97 to 0.99; p < 0.001) with a best cutoff value of Pd/Pa ≤0.91. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 93.0%, 91.4%, 94.4%, 93.3%, and 92.7%, respectively. These results were similar in patients with acute coronary syndrome and stable angina. Conclusions: Pd/Pa was analyzable in a significantly higher number of patients than iFR. Pd/Pa showed excellent agreement with iFR, suggesting that it could be applied clinically in a similar fashion. (Can Contrast Injection Better Approximate FFR Compared to Pure Resting Physiology? [CONTRAST]; NCT02184117)