126 research outputs found
Rethinking the Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy.
The Core List of Journals for Libraries that Serve Schools and Colleges of Pharmacy is a guide for developing and maintaining pharmacy-affiliated library collections. A work group was created to update the list and design a process for updating that will streamline future revisions. Work group members searched the National Library of Medicine catalog for an initial list of journals and then applied inclusion criteria to narrow the list. The work group finalized the fifth edition of the list with 225 diverse publications and produced a sustainable set of criteria for journal inclusion, providing a structured, objective process for future updates
Profiles in Science: John Bennett Fenn
âDonât ever try to be a scientist or engineer!â Had John Bennett Fenn listened to this advice given by his ninth grade teacher, he might not have gone on to pursue a career in analytical chemistry which would culminate in the attainment of the Nobel Prize in 2002. Gathered from interviews, publication analyses, glowing tributes, and his reminiscences, this paper outlines the academic and professional life of John Fenn from childhood through the end of his career in 2010
Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity
The plant homeodomain (PHD) finger is found in many chromatin-associated proteins and functions to recruit effector proteins to chromatin through its ability to bind both methylated and unmethylated histone residues. Here, we show that the dual PHD fingers of Rco1, a member of the Rpd3S histone deacetylase complex recruited to transcribing genes, operate in a combinatorial manner in targeting the Rpd3S complex to histone H3 in chromatin. Although mutations in either the first or second PHD finger allow for Rpd3S complex formation, the assembled complexes from these mutants cannot recognize nucleosomes or function to maintain chromatin structure and prevent cryptic transcriptional initiation from within transcribed regions. Taken together, our findings establish a critical role of combinatorial readout in maintaining chromatin organization and in enforcing the transcriptional fidelity of genes
Recommended from our members
The utilization of an ocular wound chamber on corneal epithelial wounds
Purpose Currently available ocular moisture chambers are not adequate to manage the treatment of periocular burns, corneal injuries, and infection. The purpose of these studies was to demonstrate that a flexible, semi-transparent ocular wound chamber device adapted from technology currently used on dermal wounds is safe for use on corneal epithelial injuries. Materials and methods A depilatory cream (Nairâą, 30 seconds) was utilized to remove the excess hair surrounding the left eyes of anesthetized Institute Armand Frappier (IAF) hairless, female guinea pigs (Crl:HA-Hrhr). A 4 mm corneal epithelium defect was created using a corneal rust ring remover (AlgerbrushÂźII). Epithelial defects were either left untreated or the eyes were fitted with an ocular wound chamber and 0.5 mL of hydroxypropyl methylcellulose (HPMC) gel (GenTealÂź) or HPMC liquid (GenTealÂź) was injected into each chamber (N=5 per group). At 0, 24, 48, and 72 hours fluorescein and optical coherence tomography imaging was collected and the intraocular pressure (IOP) was measured. H&E staining was performed on corneal and eyelid skin samples and evaluated by a veterinary pathologist. Results: Corneal epithelial wounds demonstrated 100% closure rates when left untreated or treated with an ocular wound chamber containing HPMC gel at 72 hours while wounds treated with an ocular wound chamber containing HPMC liquid were 98% healed. No significant differences were found in corneal thickness and wound healing, IOP, or eyelid skin pathology in any treatment group when compared to controls. Conclusions: This study indicates that adapted wound chamber technology can be safely used on sterile, corneal epithelial wounds without adverse effects on periocular or ocular tissue when filled with a liquid or gel
Toward a Quantitative Estimate of Future Heat Wave Mortality under Global Climate Change
Background: Climate change is anticipated to affect human health by changing the distribution of known risk factors. Heat waves have had debilitating effects on human mortality, and global climate models predict an increase in the frequency and severity of heat waves. The extent to which climate change will harm human health through changes in the distribution of heat waves and the sources of uncertainty in estimating these effects have not been studied extensively. Objectives: We estimated the future excess mortality attributable to heat waves under global climate change for a major U.S. city. Methods: We used a database comprising daily data from 1987 through 2005 on mortality from all nonaccidental causes, ambient levels of particulate matter and ozone, temperature, and dew point temperature for the city of Chicago, Illinois. We estimated the associations between heat waves and mortality in Chicago using Poisson regression models. Results: Under three different climate change scenarios for 2081â2100 and in the absence of adaptation, the city of Chicago could experience between 166 and 2,217 excess deaths per year attributable to heat waves, based on estimates from seven global climate models. We noted considerable variability in the projections of annual heat wave mortality; the largest source of variation was the choice of climate model. Conclusions: The impact of future heat waves on human health will likely be profound, and significant gains can be expected by lowering future carbon dioxide emissions
Metagenomic Analysis of Lysogeny in Tampa Bay: Implications for Prophage Gene Expression
Phage integrase genes often play a role in the establishment of lysogeny in temperate phage by catalyzing the integration of the phage into one of the host's replicons. To investigate temperate phage gene expression, an induced viral metagenome from Tampa Bay was sequenced by 454/Pyrosequencing. The sequencing yielded 294,068 reads with 6.6% identifiable. One hundred-three sequences had significant similarity to integrases by BLASTX analysis (eâ€0.001). Four sequences with strongest amino-acid level similarity to integrases were selected and real-time PCR primers and probes were designed. Initial testing with microbial fraction DNA from Tampa Bay revealed 1.9Ă107, and 1300 gene copies of Vibrio-like integrase and Oceanicola-like integrase Lâ1 respectively. The other two integrases were not detected. The integrase assay was then tested on microbial fraction RNA extracted from 200 ml of Tampa Bay water sampled biweekly over a 12 month time series. Vibrio-like integrase gene expression was detected in three samples, with estimated copy numbers of 2.4-1280 Lâ1. Clostridium-like integrase gene expression was detected in 6 samples, with estimated copy numbers of 37 to 265 Lâ1. In all cases, detection of integrase gene expression corresponded to the occurrence of lysogeny as detected by prophage induction. Investigation of the environmental distribution of the two expressed integrases in the Global Ocean Survey Database found the Vibrio-like integrase was present in genome equivalents of 3.14% of microbial libraries and all four viral metagenomes. There were two similar genes in the library from British Columbia and one similar gene was detected in both the Gulf of Mexico and Sargasso Sea libraries. In contrast, in the Arctic library eleven similar genes were observed. The Clostridium-like integrase was less prevalent, being found in 0.58% of the microbial and none of the viral libraries. These results underscore the value of metagenomic data in discovering signature genes that play important roles in the environment through their expression, as demonstrated by integrases in lysogeny
The Vehicle, Spring 1993
1993 Commemorative Edition: Celebrating 35 Years
Table of Contents
The Vehicle Editors\u27 Lineagepage 5
Milestonespage 6
THE SIXTIES
Coverspage 7
Editors\u27 Notespage 8
Sureness is Never - excerptDon Shepardsonpage 9
SophisticationBenjamin Polkpage 10
A SonnetMignon Stricklandpage 11
The Twenty-Third ChannelBen Polkpage 11
Opposite AttractionsC.E.M. (Christine McColl)page 12
John F. KennedyJoel E. Hendrickspage 13
The Girl on the White PonyLarry Gatespage 14
The TimesW.D.M. (William Moser)page 16
Home ThoughtsJane Careypage 17
1966Roger Zulaufpage 18
Nagging ThoughtJanet Andrewspage 18
THE SEVENTIES
Coverspage 19
Editors\u27 Notespage 20
RevolutionsSteve Siegelpage 21
UntitledKristine Kirkhampage 23
The Arithmetic ProblemJanice Forbuspage 23
Willie Seeverson Threw a Worm at MeMary Pipekpage 24
a love poem (by approximation)Ted Baldwinpage 25
Night and Summer in Two WorldsBarry Smithpage 26
Story of a Teenage PickleTerry Louis Schultzpage 27
Danny Lonely, Danny WildDevin Brownpage 28
Always TomorrowMary McDanielpage 29
THE EIGHTIES
Coverspage 31
Having ChildrenDevon Flesorpage 33
What is Unnatural Is Sometimes MagicAngelique Jenningspage 34
If My Father Were A Writer, He Would Still BuildAngelique Jenningspage 35
Photo AlbumPatrick Peterspage 36
Poet Born in Pearl HarborAngelique Jenningspage 37
The History of High School BasketballPatrick Peterspage 38
Banana BreadGail Bowerpage 39
Cover LetterBob Zordanipage 40
Home MoviesBob Zordanipage 41
MigrationPatrick Peterspage 42
THE NINETIES
Ba, Ba, Black SheepVictoria Bennettpage 45
Daily LessonsJennifer Moropage 49
Folding My OwnLaurie Ann Malispage 51
About the Authorspage 53
Editors\u27 Notespage 56https://thekeep.eiu.edu/vehicle/1062/thumbnail.jp
The Vehicle, Spring 1993
1993 Commemorative Edition: Celebrating 35 Years
Table of Contents
The Vehicle Editors\u27 Lineagepage 5
Milestonespage 6
THE SIXTIES
Coverspage 7
Editors\u27 Notespage 8
Sureness is Never - excerptDon Shepardsonpage 9
SophisticationBenjamin Polkpage 10
A SonnetMignon Stricklandpage 11
The Twenty-Third ChannelBen Polkpage 11
Opposite AttractionsC.E.M. (Christine McColl)page 12
John F. KennedyJoel E. Hendrickspage 13
The Girl on the White PonyLarry Gatespage 14
The TimesW.D.M. (William Moser)page 16
Home ThoughtsJane Careypage 17
1966Roger Zulaufpage 18
Nagging ThoughtJanet Andrewspage 18
THE SEVENTIES
Coverspage 19
Editors\u27 Notespage 20
RevolutionsSteve Siegelpage 21
UntitledKristine Kirkhampage 23
The Arithmetic ProblemJanice Forbuspage 23
Willie Seeverson Threw a Worm at MeMary Pipekpage 24
a love poem (by approximation)Ted Baldwinpage 25
Night and Summer in Two WorldsBarry Smithpage 26
Story of a Teenage PickleTerry Louis Schultzpage 27
Danny Lonely, Danny WildDevin Brownpage 28
Always TomorrowMary McDanielpage 29
THE EIGHTIES
Coverspage 31
Having ChildrenDevon Flesorpage 33
What is Unnatural Is Sometimes MagicAngelique Jenningspage 34
If My Father Were A Writer, He Would Still BuildAngelique Jenningspage 35
Photo AlbumPatrick Peterspage 36
Poet Born in Pearl HarborAngelique Jenningspage 37
The History of High School BasketballPatrick Peterspage 38
Banana BreadGail Bowerpage 39
Cover LetterBob Zordanipage 40
Home MoviesBob Zordanipage 41
MigrationPatrick Peterspage 42
THE NINETIES
Ba, Ba, Black SheepVictoria Bennettpage 45
Daily LessonsJennifer Moropage 49
Folding My OwnLaurie Ann Malispage 51
About the Authorspage 53
Editors\u27 Notespage 56https://thekeep.eiu.edu/vehicle/1062/thumbnail.jp
Bioavailability of Macro and Micronutrients Across Global Topsoils: Main Drivers and Global Change Impacts
Understanding the chemical composition of our planet\u27s crust was one of the biggest questions of the 20th century. More than 100 years later, we are still far from understanding the global patterns in the bioavailability and spatial coupling of elements in topsoils worldwide, despite their importance for the productivity and functioning of terrestrial ecosystems. Here, we measured the bioavailability and coupling of thirteen macro- and micronutrients and phytotoxic elements in topsoils (3â8 cm) from a range of terrestrial ecosystems across all continents (âŒ10,000 observations) and in response to global change manipulations (âŒ5,000 observations). For this, we incubated between 1 and 4 pairs of anionic and cationic exchange membranes per site for a mean period of 53 days. The most bioavailable elements (Ca, Mg, and K) were also amongst the most abundant in the crust. Patterns of bioavailability were biome-dependent and controlled by soil properties such as pH, organic matter content and texture, plant cover, and climate. However, global change simulations resulted in important alterations in the bioavailability of elements. Elements were highly coupled, and coupling was predictable by the atomic properties of elements, particularly mass, mass to charge ratio, and second ionization energy. Deviations from the predictable coupling-atomic mass relationship were attributed to global change and agriculture. Our work illustrates the tight links between the bioavailability and coupling of topsoil elements and environmental context, human activities, and atomic properties of elements, thus deeply enhancing our integrated understanding of the biogeochemical connections that underlie the productivity and functioning of terrestrial ecosystems in a changing world
Recommended from our members
Linking soil microbial community structure to potential carbon mineralization: A continental scale assessment of reduced tillage
Potential carbon mineralization (Cmin) is a commonly used indicator of soil health, with greater Cmin values interpreted as healthier soil. While Cmin values are typically greater in agricultural soils managed with minimal physical disturbance, the mechanisms driving the increases remain poorly understood. This study assessed bacterial and archaeal community structure and potential microbial drivers of Cmin in soils maintained under various degrees of physical disturbance. Potential carbon mineralization, 16S rRNA sequences, and soil characterization data were collected as part of the North American Project to Evaluate Soil Health Measurements (NAPESHM). Results showed that type of cropping system, intensity of physical disturbance, and soil pH influenced microbial sensitivity to physical disturbance. Furthermore, 28% of amplicon sequence variants (ASVs), which were important in modeling Cmin, were enriched under soils managed with minimal physical disturbance. Sequences identified as enriched under minimal disturbance and important for modeling Cmin, were linked to organisms which could produce extracellular polymeric substances and contained metabolic strategies suited for tolerating environmental stressors. Understanding how physical disturbance shapes microbial communities across climates and inherent soil properties and drives changes in Cmin provides the context necessary to evaluate management impacts on standardized measures of soil microbial activity
- âŠ