Editorial: Type I and Type III Interferon Immune Responses in Asthma

Editorial on the Research Topic Type I and Type III Interferon Immune Responses in Asthm

Food allergy in a child with de novo KAT6A mutation

Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet. The present case does not establish proof of cause, but highlights the importance of careful clinical diagnostics despite other possible causes for feeding problems. Recognizing that early feeding problems these patients regularly have might be caused by food allergy is important for outcome and quality of life for these patients

Systemic T-helper and T-regulatory cell type cytokine responses in rhinovirus vs. respiratory syncytial virus induced early wheezing: an observational study

<p>Abstract</p> <p>Background</p> <p>Rhinovirus (RV) associated early wheezing has been recognized as an independent risk factor for asthma. The risk is more important than that associated with respiratory syncytial virus (RSV) disease. No comparative data are available on the immune responses of these diseases.</p> <p>Objective</p> <p>To compare T-helper₁(Th₁), Th₂and T-regulatory (T_reg) cell type cytokine responses between RV and RSV induced early wheezing.</p> <p>Methods</p> <p>Systemic Th₁-type (interferon [IFN] -gamma, interleukin [IL] -2, IL-12), Th₂-type (IL-4, IL-5, IL-13) and T_reg-type (IL-10) cytokine responses were studied from acute and convalescence phase serum samples of sole RV (n = 23) and RSV affected hospitalized wheezing children (n = 27). The pre-defined inclusion criteria were age of 3-35 months and first or second wheezing episode. Analysis was adjusted for baseline differences. Asymptomatic children with comparable demographics (n = 11) served as controls for RV-group.</p> <p>Results</p> <p>RV-group was older and had more atopic characteristics than RSV-group. At acute phase, RV-group had higher (fold change) IL-13 (39-fold), IL-12 (7.5-fold), IFN-gamma (6.0-fold) and IL-5 (2.8-fold) concentrations than RSV-group and higher IFN-gamma (27-fold), IL-2 (8.9-fold), IL-5 (5.6-fold) and IL-10 (2.6-fold) than the controls. 2-3 weeks later, RV-group had higher IFN-gamma (>100-fold), IL-13 (33-fold) and IL-10 (6.5-fold) concentrations than RSV-group and higher IFN-gamma (15-fold) and IL-2 (9.4-fold) than the controls. IL-10 levels were higher in acute phase compared to convalescence phase in both infections (p < 0.05 for all).</p> <p>Conclusion</p> <p>Our results support a hypothesis that RV is likely to trigger wheezing mainly in children with a predisposition. IL-10 may have important regulatory function in acute viral wheeze.</p

Merkel cell polyomavirus and trichodysplasia spinulosa-associated polyomavirus DNAs and antibodies in blood among the elderly

Peer reviewe

No Correlation Between Nasopharyngeal Human Bocavirus 1 Genome Load and mRNA Detection or Serology in Adeno-/Tonsillectomy Patients

Human bocavirus 1 (HBoV1) can persist in nasopharynx and tonsils. Using HBoV1 serology, reverse-transcription polymerase chain reaction (PCR) for detecting messenger RNA (mRNA) and quantitative PCR for HBoV1 genome load count, we studied to what extent the HBoV1 DNA loads in nasopharynx correlate with acute infection markers. Tonsillar tissue, nasopharyngeal aspirate, and serum were obtained from 188 elective adeno-/tonsillectomy patients. Relatively high loads of HBoV1 DNA were detected in the nasopharynx of 14 (7%) primarily asymptomatic subjects with negative mRNA and/or serodiagnostic results. Quantitative HBoV1 DNA PCR may have lower specificity than HBoV1 mRNA detection for diagnosing symptomatic infection.Peer reviewe

Biotin IgM Antibodies in Human Blood: A Previously Unknown Factor Eliciting False Results in Biotinylation-Based Immunoassays

Peer reviewe

Observational study of inhaled corticosteroid treatment for improved expiratory variability index in steroid-naive asthmatic children

Non peer reviewe

Flunssaisen vauvan uloshengitys vinkuu - mistä taudista on kyse?

Bronkioliitti on viruksen aiheuttama pienten hengitysteiden tulehdussairaus, joka johtaa ensimmäiseen uloshengitysvaikeuskohtaukseen tiukan määritelmän mukaisesti alle 6 kuukauden ikäisellä ja laajan määritelmän mukaisesti alle 2-vuotiaalla lapsella. RSV-bronkioliitti ja ”rinovirus-atopiavinkuna” ovat erilaiset sairaudet, joiden riskitekijät, patogeneesi, taudinkulku, hoito ja ennuste eroavat toisistaan