Comparison of 68Ga-DOTANOC with 18F-FDG using PET/MRI imaging in patients with pulmonary tuberculosis

We compared the somatostatin analog radioligand, DOTANOC, with FDG, to determine whether there was increased detection of active or sub-clinical lesions in pulmonary tuberculosis (TB) with DOTANOC. Three groups were recruited: (1) active pulmonary TB; (2) IGRA-positive household TB contacts; (3) pneumonia (non-TB). DOTANOC PET/MRI followed by FDG PET/MRI was performed in active TB and pneumonia groups. TB contacts underwent FDG PET/MRI, then DOTANOC PET/MRI if abnormalities were detected. Quantitative and qualitative analyses were performed for total lung and individual lesions. Eight active TB participants, three TB contacts and three pneumonia patients had paired PET/MRI scans. In the active TB group, median SUVmax[FDG] for parenchymal lesions was 7.69 (range 3.00–15.88); median SUVmax[DOTANOC] was 2.59 (1.48–6.40). Regions of tracer uptake were fairly similar for both radioligands, albeit more diffusely distributed in the FDG scans. In TB contacts, two PET/MRIs had parenchymal lesions detected with FDG (SUVmax 5.50 and 1.82), with corresponding DOTANOC uptake < 1. FDG and DOTANOC uptake was similar in pneumonia patients (SUVmax[FDG] 4.17–6.18; SUVmax[DOTANOC] 2.92–4.78). DOTANOC can detect pulmonary TB lesions, but FDG is more sensitive for both active and sub-clinical lesions. FDG remains the preferred ligand for clinical studies, although DOTANOC may provide additional value for pathogenesis studies

Imaging brachial plexus pathology

10.37549/ar2610Applied Radiology486Oct-2

State-of-the-Art Imaging Techniques in Metastatic Spinal Cord Compression

10.3390/cancers14133289Cancers14133289

Ventriculoperitoneal shunt related meningioma: a case report

Meningiomas are the most common primary, non-glial tumours of the brain and spine, and represent the most common extra-axial lesions. The typical meningioma is a dural-based, markedly enhancing extra-axial mass; they exhibit cortical buckling with trapped cerebrospinal fluid clefts or cortical vessels. There are factors strongly associated with risk of developing meningioma, as in the case of exposure to ionizing radiation, or exogenous or endogenous hormones, as in this case, the presence of shunt material as a foreign body may have contributed to oncogenesis on the basis of a chronic inflammatory reaction. The aim of this report is to present the clinical case of a meningioma, which enveloped the proximal catheter of ventriculoperitoneal shunt valve

Deep Learning Model for Grading Metastatic Epidural Spinal Cord Compression on Staging CT

10.3390/cancers14133219Cancers14133219