Predictive direct flux control - a new control method of voltage source inverters in distributed generation applications

Version of RecordPublishe

Predictive control of power electronics converters in renewable energy systems

Version of RecordPublishe

Robust design optimization of PM-SMC motors for six sigma quality manufacturing

In our previous work, soft magnetic composite (SMC) material was employed to design cores for two kinds of permanent magnet (PM) motors, namely transverse flux machine (TFM) and claw pole motor. Compared with motors designed by traditional silicon steel sheets, these motors require 3D flux design with new material and new manufacturing method. Meanwhile, the performances of these motors highly depend on the material and manufacturing parameters besides structure parameters. Therefore, we present a robust design optimization method for high quality manufacturing of these PM-SMC motors to improve their industrial applications. Thereafter, from the design analysis of a PM-SMC TFM, it can be found that the proposed method can significantly improve the manufacturing quality and reliability of the motor, and reduce the manufacturing cost. © 1965-2012 IEEE

The effect of clozapine on mRNA expression for genes encoding G protein-coupled receptors and the protein components of clathrin-mediated endocytosis.

Clathrin-mediated endocytosis (CME) is an intracellular trafficking mechanism for packaging cargo, including G protein-coupled receptors (GPCRs), into clathrin-coated vesicles (CCVs). The antipsychotic chlorpromazine inhibits CCV assembly of adaptor protein AP2 whereas clozapine increases serotonin2A receptor internalization. We hypothesized that clozapine alters the expression of CME genes modulating vesicle turnover and GPCR internalization

The impacts of the trade liberalization of environmental goods on power system and CO2 emissions

The trade liberalization of Environmental Goods (EG), through as Environmental Goods Agreement (EGA), is crucial in low carbon electricity technology diffusion. However, there is a big gap of the EG definition lists and the integrated effectiveness analysis of EGA. This paper analyses the effects of the trade liberalization of EG based on macroeconomic and electricity sector models and attempts to find a more efficient EG trade policy by comparing different EG lists, considering end-use control and combining the EG policy with a carbon tax. The results show that the trade liberalization of EG does not necessarily benefit the environment without other policies, as the effects of the multiple end-uses of EG on conventional energy might result in environmental damage. We find that merging an EGA into a global carbon tax system would enhance the effects of carbon tax on CO2 reduction by 33%, and simultaneously lower the GDP loss due to the carbon tax by 75%. The economic benefits from the EGA could offset the costs of other environmental policies. Thus, end-use control and other environmental policies should be considered at both the global and regional levels in the setting of international trade agreements that target EG

Structural phase transition in IrTe2_2: A combined study of optical spectroscopy and band structure calculations

Ir$_{1-x}$Pt$_x$Te$_2$ is an interesting system showing competing phenomenon between structural instability and superconductivity. Due to the large atomic numbers of Ir and Te, the spin-orbital coupling is expected to be strong in the system which may lead to nonconventional superconductivity. We grew single crystal samples of this system and investigated their electronic properties. In particular, we performed optical spectroscopic measurements, in combination with density function calculations, on the undoped compound IrTe$_2$ in an effort to elucidate the origin of the structural phase transition at 280 K. The measurement revealed a dramatic reconstruction of band structure and a significant reduction of conducting carriers below the phase transition. We elaborate that the transition is not driven by the density wave type instability but caused by the crystal field effect which further splits/separates the energy levels of Te (p$_x$, p$_y$) and Te p$_z$ bands.Comment: 16 pages, 5 figure

Synthesis, structure, and magnetism in the ferromagnet La_{3}MnAs_{5}: Well-separated spin chains coupled via itinerant electrons

In this work, we systematically report the synthesis, structure, and magnetism of a compound of filled anti-Mn3Si5 type La3MnAs5. It crystallizes in a hexagonal structure with the space group of P63/mcm (193). The structure consists of face-sharing MnAs6 octahedral chains along the c axis, which are well separated by a large distance of 8.9913 Å, demonstrating a strong one-dimensional (1D) structural character. Physical property measurements indicate that La3MnAs5 is a ferromagnetic metal with TC ∼ 112 K. Due to the short-range intrachain spin coupling, the susceptibility deviates from the Curie-Weiss behavior in a wide temperature window and the magnetic entropy corresponding to the ferromagnetic transition is significantly lower than that expected from the fully saturated state. The magnetic critical behavior studies show that La3MnAs5 can be described by the three-dimensional Heisenberg model. The orbital hybridization between the 1D MnAs6 chain and intermediate La atom near the Fermi level reveals that the itinerant electrons play a key role in transmitting spin interaction among the MnAs6 spin chains. Our results indicate that La3MnAs5 is a rare ferromagnetic metal with well-separated spin chains, which provides a good opportunity to study the mechanism of interchain spin coupling via itinerant electrons

Risk of lung cancer associated with domestic use of coal in Xuanwei, China: retrospective cohort study

Objective: To estimate the risk of lung cancer associated with the use of different types of coal for household cooking and heating. Setting: Xuanwei County, Yunnan Province, China. Design: Retrospective cohort study (follow-up 1976-96) comparing mortality from lung cancer between lifelong users of “smoky coal” (bituminous) and “smokeless coal” (anthracite). Participants: 27 310 individuals using smoky coal and 9962 individuals using smokeless coal during their entire life. Main outcome measures: Primary outcomes were absolute and relative risk of death from lung cancer among users of different types of coal. Unadjusted survival analysis was used to estimate the absolute risk of lung cancer, while Cox regression models compared mortality hazards for lung cancer between smoky and smokeless coal users. Results: Lung cancer mortality was substantially higher among users of smoky coal than users of smokeless coal. The absolute risks of lung cancer death before 70 years of age for men and women using smoky coal were 18% and 20%, respectively, compared with less than 0.5% among smokeless coal users of both sexes. Lung cancer alone accounted for about 40% of all deaths before age 60 among individuals using smoky coal. Compared with smokeless coal, use of smoky coal was associated with an increased risk of lung cancer death (for men, hazard ratio 36 (95% confidence interval 20 to 65); for women, 99 (37 to 266)). Conclusions: In Xuanwei, the domestic use of smoky coal is associated with a substantial increase in the absolute lifetime risk of developing lung cancer and is likely to represent one of the strongest effects of environmental pollution reported for cancer risk. Use of less carcinogenic types of coal could translate to a substantial reduction of lung cancer risk

Amplicon-based next-generation sequencing of plasma cell-free DNA for detection of driver and resistance mutations in advanced non-small cell lung cancer

BACKGROUND: Genomic analysis of plasma cell-free DNA is transforming lung cancer care; however, available assays are limited by cost, turnaround time, and imperfect accuracy. Here, we study amplicon-based plasma next-generation sequencing (NGS), rather than hybrid-capture-based plasma NGS, hypothesizing this would allow sensitive detection and monitoring of driver and resistance mutations in advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: Plasma samples from patients with NSCLC and a known targetable genotype (EGFR, ALK/ROS1, and other rare genotypes) were collected while on therapy and analyzed blinded to tumor genotype. Plasma NGS was carried out using enhanced tagged amplicon sequencing of hotspots and coding regions from 36 genes, as well as intronic coverage for detection of ALK/ROS1 fusions. Diagnostic accuracy was compared with plasma droplet digital PCR (ddPCR) and tumor genotype. RESULTS: A total of 168 specimens from 46 patients were studied. Matched plasma NGS and ddPCR across 120 variants from 80 samples revealed high concordance of allelic fraction (R2 = 0.95). Pretreatment, sensitivity of plasma NGS for the detection of EGFR driver mutations was 100% (30/30), compared with 87% for ddPCR (26/30). A full spectrum of rare driver oncogenic mutations could be detected including sensitive detection of ALK/ROS1 fusions (8/9 detected, 89%). Studying 25 patients positive for EGFR T790M that developed resistance to osimertinib, 15 resistance mechanisms could be detected including tertiary EGFR mutations (C797S, Q791P) and mutations or amplifications of non-EGFR genes, some of which could be detected pretreatment or months before progression. CONCLUSIONS: This blinded analysis demonstrates the ability of amplicon-based plasma NGS to detect a full range of targetable genotypes in NSCLC, including fusion genes, with high accuracy. The ability of plasma NGS to detect a range of preexisting and acquired resistance mechanisms highlights its potential value as an alternative to single mutation digital PCR-based plasma assays for personalizing treatment of TKI resistance in lung cancer