Assessment measures for specific language impairment in Brazil: A systematic review

Specific Language Impairment (SLI) is defined as an unexpected failure in linguistic abilities during a child\u27s early years of development. Children with SLI do not present significant impairment in nonverbal intellectual outcomes and do not lack normal environmental exposure to language. Brazilian and worldwide researchers have sought to understand the cultural implications of SLI in the Brazilian Portuguese language. Standardized and validated measures must be used in empirical studies. The present study systematically reviewed the instruments used to assess linguistic abilities in quantitative SLI research in Brazil. Three databases were chosen: Medline, SciELO, and Google Scholar. From a total of 828 articles retrieved, only 10 met the inclusion criteria. Seven standardized assessment measures were identified. However, only two of these reported psychometric properties using adequate normative data. No normalized instrument measured the entire spectrum of linguistic abilities. We discuss the results from the perspective of SLI theories and evidence in Brazil and worldwide

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Psychobiological Aspects of Panic Disorder

Anxiety is a useful warning sign that helps an individual face potential or real danger. At appropriate levels, it serves as a warning for the presence of internal or external threats, causing a person to be alert and prepare to deal appropriately with such situations. Moreover, moderate levels of anxiety can lead to improved performance in several activities. However, anxiety becomes pathological when its duration is excessively long or its intensity is extremely high and leads to significant suffering and distress. In such cases, anxiety is appropriately described as part of a pathological response, characterizing an anxiety disorder. The historical concept of a unitary anxiety disorder has been replaced by a heterogeneous group of psychopathologies with different etiologies. Panic disorder is a complex anxiety disorder that involves both recurrent, unexpected panic attacks, and persistent concern about having additional attacks. The present chapter reviews current psychobiological perspectives in the etiology and treatment of panic disorder. The first section describes the current classification of this anxiety disorder. We then explore possible neural circuitry associated with panic disorder. Finally, the chapter addresses current treatment approaches, considering the efficacy of different forms of psychotherapy and pharmacological treatments

WORKING MEMORY IN ALZHEIMER DISEASE: A 5-YEAR SYSTEMATIC REVIEW OF EMPIRICAL EVIDENCES FROM BADDELEY’S WORKING MEMORY MODEL

The Alzheimer’s disease is the most common of theneurogenerative conditions associated with dementia. Itis known as a pathological frame that comes with severalimpairments in cognitive and psychological processes.This study aimed to understand the relationship betweenAlzheimer’s disease and Working Memory impairments.We adopted Baddeley’s Working Memory Model tosystematically review if impairments in the subcomponentsof this theoretical model – phonological loop, visualsketchpad, episodic buffer and central executive – followdistinct or similar paths. The systematic review consultedMedline, Psycinfo and Scielo databases. From 329 articles,only 11 were accepted by the established criteria. Resultssuggested that episodic buffer and central executive,respectively, decline with AD severity. Phonological loopand visual sketchpad are the last of the Baddeley’s WorkingMemory Model subcomponents impaired

Modulatory effect of diphenyl diselenide in Carioca High- and Low-conditioned Freezing rats

AbstractDiphenyl diselenide ([PhSe]2)is an organoselenium compound that has interesting pharmacological properties, including antioxidant, glutathione peroxidase-mimetic, and neuroprotective effects. The objective of the present study was to investigate the possible modulatory effect of (PhSe)2 in 17th-generation Carioca high-and low-conditioned freezing (CHF and CLF) rats, an animal model of generalized anxiety disorders. (PhSe)2 was administered at three doses (10, 50, and 100mg/kg) in CHF and CLF rats, and their anxiety-like profiles (conditioned freezing patterns) were measured before and 30min after treatment. A significant difference was found in freezing scores between CHF and CLF animals before treatment (t70=12.50, p<0.001). Treatment with (PhSe)2 at 10 and 50mg/kg decreased freezing in CHF rats but significantly increased freezing at 100mg/kg. (PhSe)2 increased freezing in CLF animals at 50 and 100mg/kg (p<0.01). These results indicate that (PhSe)2 exerts both anxiolytic- and anxiogenic-like effects in bi-directional rat lines. Distinct genetic profiles of the CHF and CLF lines may influence biochemical functions and lead to differential responses to aversive situations and various drugs like (PhSe)2