Rapid production of advanced atherosclerosis in swine by a combination of endothelial injury and cholesterol feeding

The aim of the current study was to find out whether a combination of a balloon endothelial cell denudation procedure and cholesterol feeding would result in more rapid development of atherosclerotic lesions in the abdominal aorta of swine than if either were used alone. The results far exceeded the expectations. The two procedures appeared to act synergistically. In the first 2 or 3 mth lesions are patchy and scattered but by 6 mth they become confluent so that practically the entire abdominal aorta is covered with thick lipid rich atherosclerotic lesions. The lesions produced by 6 mth have many of the characteristics of advanced human lesions.link_to_subscribed_fulltex